GSBS Student Publications

Title

Interrelationships of transcriptional machinery with nuclear architecture

GSBS Program

Biochemistry & Molecular Pharmacology

Publication Date

2000-01-29

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

There is increasing evidence for functional linkages between nuclear architecture and the regulation of gene expression. The nuclear matrix provides a paradigm for involvement of nuclear morphology in assembly of the biochemical machinery for physiological control of transcription. Mechanisms are being experimentally defined that direct regulatory factors to subnuclear sites that support gene expression. Consequently, we are gaining insight into the rules that govern transcriptional control within the three-dimensional context of nuclear organization.

Source

Crit Rev Eukaryot Gene Expr. 1999;9(3-4):183-90.

Journal/Book/Conference Title

Critical reviews in eukaryotic gene expression

Related Resources

Link to Article in PubMed

PubMed ID

10651235

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