Interrelationships of transcriptional machinery with nuclear architecture
Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center
Life Sciences | Medicine and Health Sciences
There is increasing evidence for functional linkages between nuclear architecture and the regulation of gene expression. The nuclear matrix provides a paradigm for involvement of nuclear morphology in assembly of the biochemical machinery for physiological control of transcription. Mechanisms are being experimentally defined that direct regulatory factors to subnuclear sites that support gene expression. Consequently, we are gaining insight into the rules that govern transcriptional control within the three-dimensional context of nuclear organization.
Crit Rev Eukaryot Gene Expr. 1999;9(3-4):183-90.
Critical reviews in eukaryotic gene expression
Stein GS, Van Wijnen AJ, Stein JL, Lian JB. (2000). Interrelationships of transcriptional machinery with nuclear architecture. Morningside Graduate School of Biomedical Sciences Student Publications. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1184