GSBS Student Publications

Title

Nuclear structure--skeletal gene expression interrelationships

Publication Date

1998-07-31

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Using the osteocalcin gene as a paradigm for bone tissue-specific transcription, evidence is presented for functional linkage of nuclear architecture with developmental and steroid hormone-responsive control. The involvement of chromatin structure, nucleosome organization and the nuclear matrix is evaluated within the context of integrating regulatory signals that activate and/or suppress transcription of the osteocalcin gene. Mechanisms are evaluated which direct the bone and hematopoietic-specific acute myelogenous leukemia/core binding factor (AML/CBF) transcription factors to nuclear matrix-associated subnuclear domains that are competent to support expression.

Source

Front Biosci. 1998 Aug 1;3:d849-64.

Journal/Book/Conference Title

Frontiers in bioscience : a journal and virtual library

Related Resources

Link to Article in PubMed

PubMed ID

9682039

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