Nuclear structure--skeletal gene expression interrelationships
Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center
Life Sciences | Medicine and Health Sciences
Using the osteocalcin gene as a paradigm for bone tissue-specific transcription, evidence is presented for functional linkage of nuclear architecture with developmental and steroid hormone-responsive control. The involvement of chromatin structure, nucleosome organization and the nuclear matrix is evaluated within the context of integrating regulatory signals that activate and/or suppress transcription of the osteocalcin gene. Mechanisms are evaluated which direct the bone and hematopoietic-specific acute myelogenous leukemia/core binding factor (AML/CBF) transcription factors to nuclear matrix-associated subnuclear domains that are competent to support expression.
Front Biosci. 1998 Aug 1;3:d849-64.
Frontiers in bioscience : a journal and virtual library
Stein, Gary S.; Van Wijnen, Andre J.; Stein, Janet L.; and Lian, Jane B., "Nuclear structure--skeletal gene expression interrelationships" (1998). GSBS Student Publications. 1183.