GSBS Student Publications
Title
Transcriptional control of cell cycle progression: the histone gene is a paradigm for the G1/S phase and proliferation/differentiation transitions
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Cell Biology
Date
1-1-1996
Document Type
Article
Medical Subject Headings
Cell Cycle; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; DNA; G1 Phase; Histones; Humans; Promoter Regions (Genetics); S Phase; Transcription, Genetic
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
The histone gene is a paradigm for transcriptional control at the G1/S phase transition point in the cell cycle. The histone gene promoter provides a blueprint for integration of regulatory signals which mediate responsiveness to factors controlling competency for cell cycle progression at the initiation of DNA replication. The downregulation of proliferation at the onset of differentiation is accompanied by and functionally linked to modifications in protein-DNA and protein-protein interactions at histone gene promoter regulatory elements. Chromatin structure, nucleosome organization and gene-nuclear matrix interactions facilitate crosstalk between regulatory sequences and targeting of transcription factors to cognate binding domains.
Rights and Permissions
Citation: Cell Biol Int. 1996 Jan;20(1):41-9. Link to article on publisher's site
DOI of Published Version
10.1006/cbir.1996.0007
Related Resources
Journal Title
Cell biology international
PubMed ID
8936406
Repository Citation
Stein, Gary S.; Stein, Janet L.; Van Wijnen, Andre J.; and Lian, Jane B., "Transcriptional control of cell cycle progression: the histone gene is a paradigm for the G1/S phase and proliferation/differentiation transitions" (1996). GSBS Student Publications. 1180.
https://escholarship.umassmed.edu/gsbs_sp/1180