Histone gene transcription: a model for responsiveness to an integrated series of regulatory signals mediating cell cycle control and proliferation/differentiation interrelationships
Document Type
Journal ArticlePublication Date
1994-04-01Keywords
Animals; Base Sequence; Cell Cycle; Cell Differentiation; Cell Division; *Gene Expression Regulation; Histones; Humans; Molecular Sequence Data; Neoplasms; Promoter Regions (Genetics); *Transcription, GeneticLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Histone gene expression is restricted to the S-phase of the cell cycle. Control is at multiple levels and is mediated by the integration of regulatory signals in response to cell cycle progression and the onset of differentiation. The H4 gene promoter is organized into a series of independent and overlapping regulatory elements which exhibit selective, phosphorylation-dependent interactions with multiple transactivation factors. The three-dimensional organization of the promoter and, in particular, its chromatin structure, nucleosome organization, and interactions with the nuclear matrix may contribute to interrelationships of activities at multiple promoter elements. Molecular mechanisms are discussed that may participate in the coordinate expression of S-phase-specific core and H1 histone genes, together with other genes functionally coupled with DNA replication.Source
J Cell Biochem. 1994 Apr;54(4):393-404. Link to article on publisher's siteDOI
10.1002/jcb.240540406Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32617PubMed ID
8014188Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1002/jcb.240540406