GSBS Student Publications

Title

Regulation of histone gene expression

Publication Date

1992-04-01

UMMS Affiliation

Graduate School of Biomedical Sciences; University of Massachusetts Medical Center

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Histone genes are expressed during the S phase of the cell cycle. Control is at multiple levels and is mediated by the integration of regulatory signals in response to cell-cycle progression and the onset of differentiation. Much work has been carried out on the H4 gene promoter, which appears to be organized into a series of distinct regulatory elements. The three-dimensional organization of the promoter and, in particular, its spatial relationship with the nuclear matrix scaffold, may be important factors of transcription regulation.

Source

Curr Opin Cell Biol. 1992 Apr;4(2):166-73.

Journal/Book/Conference Title

Current opinion in cell biology

Related Resources

Link to Article in PubMed

PubMed ID

1599687

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