GSBS Student Publications

Title

Nuclear microenvironments: an architectural platform for the convergence and integration of transcriptional regulatory signals

Publication Date

2004-05-18

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Functional interrelationships between the intranuclear organization of nucleic acids and regulatory proteins are obligatory for fidelity of transcriptional activation and repression. In this article, using the Runx/AML/Cbfa transcription factors as a paradigm for linkage between nuclear structure and gene expression we present an overview of growing insight into the dynamic organization and assembly of regulatory machinery for gene expression at microenvironments within the nucleus. We address contributions of nuclear microenvironments to the convergence and integration of regulatory signals that mediate transcription by supporting the combinatorial assembly of regulatory complexes.

Source

Eur J Histochem. 2004;48(1):65-76.

Journal/Book/Conference Title

European journal of histochemistry : EJH

Related Resources

Link to Article in PubMed

PubMed ID

15145777

Share

COinS