Nuclear microenvironments: an architectural platform for the convergence and integration of transcriptional regulatory signals
Authors
Stein, Gary S.Stein, Janet L.
Lian, Jane B.
Van Wijnen, Andre J.
Montecino, Martin A.
Javed, Amjad
Zaidi, Sayyed K.
Young, Daniel W.
Choi, Je-Yong
Pockwinse, Shirwin M.
UMass Chan Affiliations
Department of Cell Biology and Cancer CenterGraduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2004-05-18Keywords
Active Transport, Cell Nucleus; Animals; Cell Nucleus; Core Binding Factor Alpha 3 Subunit; Core Binding Factor alpha Subunits; DNA-Binding Proteins; *Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Neoplasm Proteins; Neoplasms; Nuclear Matrix; *Signal Transduction; Transcription Factors; Transcription, GeneticLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Functional interrelationships between the intranuclear organization of nucleic acids and regulatory proteins are obligatory for fidelity of transcriptional activation and repression. In this article, using the Runx/AML/Cbfa transcription factors as a paradigm for linkage between nuclear structure and gene expression we present an overview of growing insight into the dynamic organization and assembly of regulatory machinery for gene expression at microenvironments within the nucleus. We address contributions of nuclear microenvironments to the convergence and integration of regulatory signals that mediate transcription by supporting the combinatorial assembly of regulatory complexes.Source
Eur J Histochem. 2004;48(1):65-76.
DOI
10.4081/860Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32614PubMed ID
15145777Related Resources
Distribution License
http://creativecommons.org/licenses/by-nc/4.0/ae974a485f413a2113503eed53cd6c53
10.4081/860
Scopus Count
Collections
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc/4.0/