Title
Functional interrelationships between nuclear structure and transcriptional control: contributions to regulation of cell cycle- and tissue-specific gene expression
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Cell Biology
Publication Date
1996-08-01
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Multiple levels of nuclear structure contribute to functional interrelationships with transcriptional control in vivo. The linear organization of gene regulatory sequences is necessary but insufficient to accommodate the requirements for physiological responsiveness to homeostatic, developmental, and tissue-related signals. Chromatin structure, nucleosome organization, and gene-nuclear matrix interactions provide a basis for rendering sequences accessible to transcription factors supporting integration of activities at independent promoter elements of cell cycle- and tissue-specific genes. A model is presented for remodeling of nuclear organization to accommodate developmental transcriptional control.
DOI of Published Version
10.1002/(SICI)1097-4644(199608)62:2andlt;198::AID-JCB8andgt;3.0.CO;2-N
Source
J Cell Biochem. 1996 Aug;62(2):198-209. Link to article on publisher's site
Journal/Book/Conference Title
Journal of cellular biochemistry
Related Resources
PubMed ID
8844400
Repository Citation
Stein GS, Stein JL, Lian JB, Van Wijnen AJ, Montecino MA. (1996). Functional interrelationships between nuclear structure and transcriptional control: contributions to regulation of cell cycle- and tissue-specific gene expression. GSBS Student Publications. https://doi.org/10.1002/(SICI)1097-4644(199608)62:2andlt;198::AID-JCB8andgt;3.0.CO;2-N. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1175