Title
Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center
Publication Date
2005-09-02
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
The architecturally associated subnuclear organization of nucleic acids and cognate regulatory factors suggests functional interrelationships between nuclear structure and gene expression. Mechanisms that contribute to the spatial distribution of transcription factors within the three dimensional context of nuclear architecture control the sorting and integration of regulatory information as well as the combinatorial assembly, organization and activities of transcriptional machinery at scaffold-associated subnuclear sites that support gene expression. During the past several years our laboratory has been addressing intranuclear trafficking mechanisms that direct transcription factors to transcriptionally active nuclear microenvironments. We are pursuing these studies using the AML/Runx/Cbfa transcription factors that govern hematopoietic and bone-specific transcription as a paradigm. Our objective is to gain insight into linkage of intranuclear organization of genes, transcripts, and regulatory proteins with fidelity of biological control and contributions of aberrant nuclear structure/function relationships to the onset and progression of tumorigenesis.
DOI of Published Version
10.1016/j.advenzreg.2005.02.009
Source
Adv Enzyme Regul. 2005;45:136-54. Epub 2005 Aug 30. Link to article on publisher's site
Journal/Book/Conference Title
Advances in enzyme regulation
Related Resources
PubMed ID
16135382
Repository Citation
Stein GS, Lian JB, Stein JL, Van Wijnen AJ, Javed A, Montecino MA, Zaidi SK, Young DW, Choi J, Pratap J. (2005). Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer. Morningside Graduate School of Biomedical Sciences Student Publications. https://doi.org/10.1016/j.advenzreg.2005.02.009. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1167