Nuclear microenvironments support physiological control of gene expression
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center
Life Sciences | Medicine and Health Sciences
There is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.
DOI of Published Version
Chromosome Res. 2003;11(5):527-36.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
Stein GS, Lian JB, Montecino MA, Stein JL, Van Wijnen AJ, Javed A, Pratap J, Choi J, Zaidi SK, Gutierrez SE, Harrington KS, Shen J, Young DW, Pockwinse SM. (2003). Nuclear microenvironments support physiological control of gene expression. Morningside Graduate School of Biomedical Sciences Student Publications. https://doi.org/10.1023/A:1024943214431. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1164