Title
Nuclear microenvironments support physiological control of gene expression
Academic Program
Biochemistry & Molecular Pharmacology
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center
Publication Date
2003-09-16
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
There is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.
DOI of Published Version
10.1023/A:1024943214431
Source
Chromosome Res. 2003;11(5):527-36.
Journal/Book/Conference Title
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
Related Resources
PubMed ID
12971727
Repository Citation
Stein GS, Lian JB, Montecino MA, Stein JL, Van Wijnen AJ, Javed A, Pratap J, Choi J, Zaidi SK, Gutierrez SE, Harrington KS, Shen J, Young DW, Pockwinse SM. (2003). Nuclear microenvironments support physiological control of gene expression. Morningside Graduate School of Biomedical Sciences Student Publications. https://doi.org/10.1023/A:1024943214431. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1164