GSBS Student Publications

Title

Nuclear microenvironments support physiological control of gene expression

Publication Date

2003-09-16

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

There is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.

Source

Chromosome Res. 2003;11(5):527-36.

Journal/Book/Conference Title

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology

Related Resources

Link to Article in PubMed

PubMed ID

12971727

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