Title
Differences in synthesis of membrane proteins by leukemic cells from spleen and peripheral blood indicate distinct subsets of malignant cells in a patient with prolymphocytic leukemia
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Pharmacology; Department of Pathology; Department of Pediatrics
Publication Date
1981-11-01
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Morphological and biochemical differences were demonstrated between prolymphocytic leukemia cells obtained from the spleen and peripheral blood of one patient. Peripheral blood prolymphocytes had consistently smaller nuclear-cytoplasmic ratios than did splenic prolymphocytes. Percoll gradient-purified prolymphocytes from the spleen synthesized abundant amounts of some membrane proteins which were hardly expressed by peripheral blood prolymphocytes. Peripheral blood prolymphocytes did not change their expression of membrane proteins during three days in culture. These findings are consistent with the view that prolymphocytic leukemia cells from the spleen exist, on the average, at an earlier stage of differentiation than do circulating leukemic cells, and that peripheral blood leukemic cells are frozen at a specific phase of differentiation.
Source
Am J Hematol. 1981 Nov;11(3):261-70.
Journal/Book/Conference Title
American journal of hematology
Related Resources
PubMed ID
6947689
Repository Citation
Spiro RC, Ansell JE, Katayama I, Muralidharan K, Sullivan JL, Humphreys RE. (1981). Differences in synthesis of membrane proteins by leukemic cells from spleen and peripheral blood indicate distinct subsets of malignant cells in a patient with prolymphocytic leukemia. GSBS Student Publications. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1147