Title
Mouse RT6 locus 1 and rat RT6.2 are NAD+. Arginine ADP-ribosyltransferases with auto-ADP-ribosylation activity
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Medicine, Diabetes Division; Department of Medicine, Division of Endocrinology and Metabolism
Publication Date
1997-01-01
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
We report that rat RT6.2 and recombinant mouse Rt6 locus 1 proteins possess auto-ADP-ribosyltransferase activity and that Rt6, but not RT6, catalyzes the ADP-ribosylation of exogenous histones. Based on NH2OH sensitivity, it appeared that the ADP-ribose was attached to arginine residues on proteins. We also observed that the NAD+ concentration in culture medium correlates inversely with the proliferation of rat RT6+ T cells. The data suggest that lymphocyte surface ADP-ribosyltransferases could be involved in signaling and immunoregulatory processes.
Source
Adv Exp Med Biol. 1997;419:169-73.
Journal/Book/Conference Title
Advances in experimental medicine and biology
Related Resources
PubMed ID
9193650
Repository Citation
Bortell R, Rigby MR, Stevens LA, Moss J, Kanaitsuka T, Mordes JP, Greiner DL, Rossini AA. (1997). Mouse RT6 locus 1 and rat RT6.2 are NAD+. Arginine ADP-ribosyltransferases with auto-ADP-ribosylation activity. GSBS Student Publications. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/113