GSBS Student Publications

Title

Structural analysis of the yeast SWI/SNF chromatin remodeling complex

Publication Date

2003-01-14

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Gene Function and Expression; Program in Molecular Medicine

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Elucidating the mechanism of ATP-dependent chromatin remodeling is one of the largest challenges in the field of gene regulation. One of the missing pieces in understanding this process is detailed structural information on the enzymes that catalyze the remodeling reactions. Here we use a combination of subunit radio-iodination and scanning transmission electron microscopy to determine the subunit stoichiometry and native molecular weight of the yeast SWI/SNF complex. We also report a three-dimensional reconstruction of yeast SWI/SNF derived from electron micrographs.

DOI of Published Version

10.1038/nsb888

Source

Nat Struct Biol. 2003 Feb;10(2):141-5. Link to article on publisher's site

Journal/Book/Conference Title

Nature structural biology

Related Resources

Link to Article in PubMed

PubMed ID

12524530

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