Cell cycle regulation of the c-Myc transcriptional activation domain
Graduate School of Biomedical Sciences; Department of Biochemistry and Molecular Biology; Program in Molecular Medicine
Life Sciences | Medicine and Health Sciences
The product of the c-myc gene (c-Myc) is a sequence-specific DNA-binding protein that has previously been demonstrated to be required for cell cycle progression. Here we report that the c-Myc DNA binding site confers cell cycle regulation to a reporter gene in Chinese hamster ovary cells. The observed transactivation was biphasic with a small increase in G1 and a marked increase during the S-to-G2/M transition of the cell cycle. This cell cycle regulation of transactivation potential is accounted for, in part, by regulatory phosphorylation of the c-Myc transactivation domain. Together, these data demonstrate that c-Myc may have an important role in the progression of cells through both the G1 and G2 phases of the cell cycle.
DOI of Published Version
Mol Cell Biol. 1993 Jul;13(7):4125-36.
Molecular and cellular biology
Seth, Alpna; Gupta, Shashi; and Davis, Roger J., "Cell cycle regulation of the c-Myc transcriptional activation domain" (1993). GSBS Student Publications. 1099.