Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Department of Pathology
Life Sciences | Medicine and Health Sciences
Using a variety of techniques, including limiting dilution assays (LDA), intracellular IFNgamma assays, and Db-IgG1 MHC dimer staining to measure viral peptide-specific T cell number and function, we show here that heterologous virus infections quantitatively delete and qualitatively alter the memory pool of T cells specific to a previously encountered virus. We also show that a prior history of a virus infection can alter the hierarchy of the immunodominant peptide response to a second virus and that virus infections selectively reactivate memory T cells with distinct specificities to earlier viruses. These results are consistent with a model for the immune system that accommodates memory T cell populations for multiple pathogens over the course of a lifetime.
DOI of Published Version
Immunity. 1999 Dec;11(6):733-42.
Selin, Liisa K.; Lin, Meei-Yun; Kraemer, Kristy A.; Pardoll, Drew M.; Schneck, Jonathan P.; Varga, Steven Michael; Santolucito, Paul A.; Pinto, Amelia K.; and Welsh, Raymond M., "Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses" (2000). GSBS Student Publications. 1088.