Title

Hemodynamic and metabolic changes induced by cocaine in anesthetized rat observed with multimodal functional MRI

Authors

Karl F. Schmidt, University of Massachusetts Medical School
Marcelo Febo, University of Massachusetts Medical School
Qiang Shen, Emory University
Feng Luo, University of Massachusetts Medical School
Kenneth M. Sicard, University of Massachusetts Medical School
Craig F. Ferris, University of Massachusetts Medical School
Elliot A. Stein, National Institutes of Health
Timothy Q. Duong, Emory University

Student Author(s)

Karl Schmidt

Academic Program

Neuroscience

UMMS Affiliation

Department of Psychiatry, Center for Comparative Neuroimaging

Publication Date

2006-03-22

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences | Neuroscience and Neurobiology

Abstract

RATIONALE: Physiological changes (such as heart rate and respiration rate) associated with strong pharmacological stimuli could change the blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) mapping signals, independent of neural activity.

OBJECTIVES: This study investigates whether the physiological changes per se associated with systemic cocaine administration (1 mg/kg) contaminate the BOLD fMRI signals by measuring BOLD and cerebral blood flow (CBF) fMRI and estimating the cerebral metabolic rate of oxygen (CMRO(2)) changes.

MATERIALS AND METHODS: BOLD and CBF fMRI was performed, and changes in CMRO(2) were estimated using the BOLD biophysical model.

RESULTS: After systemic cocaine administration, blood pressure, heart rate, and respiration rate increased, fMRI signals remained elevated after physiological parameters had returned to baseline. Cocaine induced changes in the BOLD signal within regions of the reward pathway that were heterogeneous and ranged from -1.2 to 5.4%, and negative changes in BOLD were observed along the cortical surface. Changes in CBF and estimated CMRO(2) were heterogeneous and positive throughout the brain, ranging from 14 to 150% and 10 to 55%, respectively.

CONCLUSIONS: This study demonstrates a valuable tool to investigate the physiological and biophysical basis of drug action on the central nervous system, offering the means to distinguish the physiological from neural sources of the BOLD fMRI signal.

DOI of Published Version

10.1007/s00213-006-0319-1

Source

Psychopharmacology (Berl). 2006 May;185(4):479-86. Epub 2006 Mar 21. Link to article on publisher's site

Journal/Book/Conference Title

Psychopharmacology

Related Resources

Link to Article in PubMed

PubMed ID

16550388

Repository Citation

Schmidt KF, Febo M, Shen Q, Luo F, Sicard KM, Ferris CF, Stein EA, Duong TQ. (2006). Hemodynamic and metabolic changes induced by cocaine in anesthetized rat observed with multimodal functional MRI. Morningside Graduate School of Biomedical Sciences Student Publications. https://doi.org/10.1007/s00213-006-0319-1. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1076