GSBS Student Publications
Title
Ectopic CRYPTOCHROME renders TIM light sensitive in the Drosophila ovary
GSBS Program
Neuroscience
UMMS Affiliation
Department of Neurobiology; Emery Lab; Graduate School of Biomedical Sciences, Neuroscience Program
Date
7-26-2006
Document Type
Article
Medical Subject Headings
Animals; Animals, Genetically Modified; Biological Clocks; Circadian Rhythm; Drosophila Proteins; Drosophila melanogaster; Eye Proteins; Female; *Light; Nuclear Proteins; Ovarian Follicle; Receptors, G-Protein-Coupled
Disciplines
Neuroscience and Neurobiology
Abstract
The period (per) and timeless (tim) genes play a central role in the Drosophila circadian clock mechanism. PERIOD (PER) and TIMELESS (TIM) proteins periodically accumulate in the nuclei of pace-making cells in the fly brain and many cells in peripheral organs. In contrast, TIM and PER in the ovarian follicle cells remain cytoplasmic and do not show daily oscillations in their levels. Moreover, TIM is not light sensitive in the ovary, while it is highly sensitive to this input in circadian tissues. The mechanism underlying this intriguing difference is addressed here. It is demonstrated that the circadian photoreceptor CRYPTOCHROME (CRY) is not expressed in ovarian tissues. Remarkably, ectopic cry expression in the ovary is sufficient to cause degradation of TIM after exposure to light. In addition, PER levels are reduced in response to light when CRY is present, as observed in circadian cells. Hence, CRY is the key component of the light input pathway missing in the ovary. However, the factors regulating PER and TIM levels downstream of light/cry action appear to be present in this non-circadian organ.
Rights and Permissions
Citation: J Biol Rhythms. 2006 Aug;21(4):272-8. Link to article on publisher's site
DOI of Published Version
10.1177/0748730406290416
Related Resources
Journal Title
Journal of biological rhythms
PubMed ID
16864647
Repository Citation
Rush, Brandy L.; Murad, Alejandro D.; Emery, Patrick; and Giebultowicz, Jadwiga M., "Ectopic CRYPTOCHROME renders TIM light sensitive in the Drosophila ovary" (2006). GSBS Student Publications. 1056.
https://escholarship.umassmed.edu/gsbs_sp/1056