Regulation of postreceptor signaling in the pheromone response pathway of Saccharomyces cerevisiae
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Department of Molecular Genetics and Microbiology
Medical Subject Headings
Adaptation, Physiological; Cell Division; Peptides; Pheromones; Receptors, Cell Surface; Receptors, Mating Factor; *Receptors, Peptide; Saccharomyces cerevisiae; *Signal Transduction; *Transcription Factors
Life Sciences | Medicine and Health Sciences
alpha-Factor pheromone inhibits division of yeast a cells. After prolonged exposure to alpha-factor, the cells adapt to the stimulus and resume cell division. The sst2 mutation is known to inhibit adaptation. This report examines adaptation in scg1 (also designated gpa1) and STE4Hpl (Hpl indicates haploid lethal) mutants that exhibit constitutive activation of the pheromone response pathway. Recovery of the STE4Hpl mutant was blocked by the sst2-1 mutation, whereas recovery of the scg1-7 mutant was not completely blocked by sst2-1. These results indicate that both SST2-dependent and -independent mechanisms regulate postreceptor events in the pheromone response pathway. Down regulation of receptors in response to alpha-factor was independent of the signal that was generated in the scg1 mutant.
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Citation: Mol Cell Biol. 1989 Sep;9(9):3720-6.
Molecular and cellular biology
Blinder, Dmitry B. and Jenness, Duane D., "Regulation of postreceptor signaling in the pheromone response pathway of Saccharomyces cerevisiae" (1989). GSBS Student Publications. 105.