GSBS Student Publications
Title
5' avian leukosis virus sequences and osteopetrotic potential
GSBS Program
Biochemistry & Molecular Pharmacology
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Pathology; Department of Molecular Genetics and Microbiology
Date
10-1-1992
Document Type
Article
Medical Subject Headings
Animals; Avian leukosis virus; Base Sequence; Chickens; Cloning, Molecular; Codon; DNA, Viral; Molecular Sequence Data; Osteopetrosis; Plasmids; RNA, Messenger; Recombination, Genetic; Repetitive Sequences, Nucleic Acid; Restriction Mapping
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Recombinants of Rous-associated virus-0 and Br21 have been used to localize 5' viral sequences that affect the osteopetrotic potential of avian leukosis viruses. Rous-associated virus-0 is a benign subgroup E virus of endogenous origin that does not cause osteopetrosis. Br21 is a constructed subgroup E virus with high osteopetrotic potential. 5' sequences that affected osteopetrotic potential resided in an 834-bp region near the 5' LTR. Sequence analysis of this region revealed differences between Br21 and RAV-0 in the mRNA leader and codons for MA.
Rights and Permissions
Citation: Virology. 1992 Oct;190(2):866-71.
Related Resources
Journal Title
Virology
PubMed ID
1325711
Repository Citation
Robinson, Harriet L.; Foster, Rosalinda Gram; Blais, Bruce P.; Reinsch, Sigrid S.; Newstein, Michael C.; and Shank, Peter R., "5' avian leukosis virus sequences and osteopetrotic potential" (1992). GSBS Student Publications. 1048.
https://escholarship.umassmed.edu/gsbs_sp/1048