GSBS Student Publications
Title
Constitutive mutants in the yeast pheromone response: ordered function of the gene products
GSBS Program
Biochemistry & Molecular Pharmacology
Publication Date
1989-02-10
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Molecular Genetics and Microbiology
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
The alpha factor pheromone inhibits the division of yeast a cells. A general method was developed for isolating mutants that exhibit constitutive activation of the pheromone response pathway. A dominant allele of the STE4 locus was recovered in addition to recessive mutations in the SCG1 gene. SCG1 and STE4 are known to encode G alpha and G beta homologs, respectively. Analysis of double mutants suggests that the STE4 gene product functions after the SCG1 product but before the STE5 product.
Source
Cell. 1989 Feb 10;56(3):479-86.
Journal/Book/Conference Title
Cell
Related Resources
PubMed ID
2644047
Repository Citation
Blinder, Dmitry B.; Bouvier, Suzanne E.; and Jenness, Duane D., "Constitutive mutants in the yeast pheromone response: ordered function of the gene products" (1989). GSBS Student Publications. 104.
https://escholarship.umassmed.edu/gsbs_sp/104