Constitutive mutants in the yeast pheromone response: ordered function of the gene products
Graduate School of Biomedical Sciences; Department of Molecular Genetics and Microbiology
Life Sciences | Medicine and Health Sciences
The alpha factor pheromone inhibits the division of yeast a cells. A general method was developed for isolating mutants that exhibit constitutive activation of the pheromone response pathway. A dominant allele of the STE4 locus was recovered in addition to recessive mutations in the SCG1 gene. SCG1 and STE4 are known to encode G alpha and G beta homologs, respectively. Analysis of double mutants suggests that the STE4 gene product functions after the SCG1 product but before the STE5 product.
Cell. 1989 Feb 10;56(3):479-86.
Blinder DB, Bouvier SE, Jenness DD. (1989). Constitutive mutants in the yeast pheromone response: ordered function of the gene products. GSBS Student Publications. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/104