GSBS Student Publications

Title

Constitutive mutants in the yeast pheromone response: ordered function of the gene products

GSBS Program

Biochemistry & Molecular Pharmacology

Publication Date

1989-02-10

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Molecular Genetics and Microbiology

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The alpha factor pheromone inhibits the division of yeast a cells. A general method was developed for isolating mutants that exhibit constitutive activation of the pheromone response pathway. A dominant allele of the STE4 locus was recovered in addition to recessive mutations in the SCG1 gene. SCG1 and STE4 are known to encode G alpha and G beta homologs, respectively. Analysis of double mutants suggests that the STE4 gene product functions after the SCG1 product but before the STE5 product.

Source

Cell. 1989 Feb 10;56(3):479-86.

Journal/Book/Conference Title

Cell

Related Resources

Link to article in PubMed

PubMed ID

2644047

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