Constitutive mutants in the yeast pheromone response: ordered function of the gene products
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Department of Molecular Genetics and Microbiology
Medical Subject Headings
Crosses, Genetic; *Genes; Genes, Dominant; *Genes, Fungal; Genes, Recessive; Genotype; *Mutation; Peptides; Phenotype; Pheromones; Saccharomyces cerevisiae
Life Sciences | Medicine and Health Sciences
The alpha factor pheromone inhibits the division of yeast a cells. A general method was developed for isolating mutants that exhibit constitutive activation of the pheromone response pathway. A dominant allele of the STE4 locus was recovered in addition to recessive mutations in the SCG1 gene. SCG1 and STE4 are known to encode G alpha and G beta homologs, respectively. Analysis of double mutants suggests that the STE4 gene product functions after the SCG1 product but before the STE5 product.
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Citation: Cell. 1989 Feb 10;56(3):479-86.
Blinder, Dmitry B.; Bouvier, Suzanne E.; and Jenness, Duane D., "Constitutive mutants in the yeast pheromone response: ordered function of the gene products" (1989). GSBS Student Publications. 104.