Functional significance of conserved amino acid residues
Graduate School of Biomedical Sciences; Graduate School of Biomedical Sciences; Department of Molecular Genetics and Microbiology
Life Sciences | Medicine and Health Sciences
A systemic study of single amino acid substitutions in bacteriophage T4 lysozyme permitted a test of the concept that conserved amino acid residues are more functionally important than nonconserved residues. Substitutions of amino acid residues that are conserved among five bacteriophage-encoded lysozymes were found to lead more frequently to loss of function than substitutions of nonconserved residues. Of 163 residues tested, only 74 (45%) are sensitive to at least one substitution; however, all 14 residues that are fully conserved are sensitive to substitutions.
DOI of Published Version
Proteins. 1992 May;13(1):38-40. Link to article on publisher's site
Poteete, Anthony R.; Rennell, Dale; and Bouvier, Suzanne E., "Functional significance of conserved amino acid residues" (1992). GSBS Student Publications. 1000.