Title
Functional significance of conserved amino acid residues
UMMS Affiliation
Graduate School of Biomedical Sciences; Graduate School of Biomedical Sciences; Department of Molecular Genetics and Microbiology
Publication Date
1992-05-01
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
A systemic study of single amino acid substitutions in bacteriophage T4 lysozyme permitted a test of the concept that conserved amino acid residues are more functionally important than nonconserved residues. Substitutions of amino acid residues that are conserved among five bacteriophage-encoded lysozymes were found to lead more frequently to loss of function than substitutions of nonconserved residues. Of 163 residues tested, only 74 (45%) are sensitive to at least one substitution; however, all 14 residues that are fully conserved are sensitive to substitutions.
DOI of Published Version
10.1002/prot.340130104
Source
Proteins. 1992 May;13(1):38-40. Link to article on publisher's site
Journal/Book/Conference Title
Proteins
Related Resources
PubMed ID
1594576
Repository Citation
Poteete AR, Rennell D, Bouvier SE. (1992). Functional significance of conserved amino acid residues. Morningside Graduate School of Biomedical Sciences Student Publications. https://doi.org/10.1002/prot.340130104. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1000