The MD/PhD Program at the University of Massachusetts Medical School combines the curricula of the Medical and Graduate schools and provides a comprehensive education in both clinical and basic science research disciplines. The goal of the program is to provide highly motivated students the opportunities to develop skills and experience in biomedical investigation and the practice of medicine. This is a rigorous and challenging program, and upon successful completion the student is awarded both the PhD in Biomedical Sciences and the MD. Our goal is to train physician-scientists who will make significant contributions to health care and who will become the leaders of academic medicine. The UMMS MD/PhD program joined the NIH Medical Scientist Training Program in 2013. This collection showcases publications and presentations authored by MD/PhD students.

Attention MD/PhD Program students: To submit your publications, go to GSBS Student Publications and click on Submit Research in the left sidebar. You’ll need to log in or create a free account. If you have the article's PubMed ID, submission is very easy. Enter the PubMed ID and information from PubMed will be used to populate the submission form. Questions? Contact Lisa Palmer.

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Publications from 2006

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The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia, Nils Henninger, Kenneth M. Sicard, James P. Bouley, Marc Fisher, and Nancy E. Stagliano

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Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging, Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, Juergen F. Bardutzky, and Marc Fisher

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A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3, Jan-Luuk Hillebrands, Barbara J. Whalen, Jeroen T. J. Visser, Jasper Koning, Kenneth D. Bishop, Jean Leif, Jan Rozing, John P. Mordes, Dale L. Greiner, and Aldo A. Rossini

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Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers, Hanchen Li, Calin Stoicov, Arlin B. Rogers, and JeanMarie Houghton

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The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons, Jennifer MacDonald, Margaret Beach, Ermelinda Porpiglia, Amy E. Sheehan, Ryan J. Watts, and Marc R. Freeman

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ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose), Alan R. Morrison, Joel Moss, Linda A. Stevens, James E. Evans, Caitlin Farrell, Eric Lee Merithew, David G. Lambright, Dale L. Greiner, John P. Mordes, Aldo A. Rossini, and Rita Bortell

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BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin, Gayle Jeannette Pageau and Jeanne B. Lawrence

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Hemodynamic and metabolic changes induced by cocaine in anesthetized rat observed with multimodal functional MRI, Karl F. Schmidt, Marcelo Febo, Qiang Shen, Feng Luo, Kenneth M. Sicard, Craig F. Ferris, Elliot A. Stein, and Timothy Q. Duong

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Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats, Kenneth M. Sicard, Nils Henninger, Marc Fisher, Timothy Q. Duong, and Craig F. Ferris

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Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats, Kenneth M. Sicard, Nils Henninger, Marc Fisher, Timothy Q. Duong, and Craig F. Ferris

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Bone marrow cells as the origin of stomach cancer, Calin Stoicov, Hanchen Li, Jane E. Carlson, and JeanMarie Houghton

Publications from 2005

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Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice, Xun Cai, Jane E. Carlson, Calin Stoicov, Hanchen Li, Timothy C. Wang, and JeanMarie Houghton

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Impaired spatial learning in a novel rat model of mild cerebral concussion injury, Nils Henninger, Stephan Dutzmann, Kenneth M. Sicard, Rainer Kollmar, Juergen F. Bardutzky, and Stefan Schwab

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Effects of hypoxia, hyperoxia, and hypercapnia on baseline and stimulus-evoked BOLD, CBF, and CMRO2 in spontaneously breathing animals, Kenneth M. Sicard and Timothy Q. Duong

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Major histocompatibility complex class II inhibits fas antigen-mediated gastric mucosal cell apoptosis through actin-dependent inhibition of receptor aggregation, Calin Stoicov, Xun Cai, Hanchen Li, Kristine Klucevsek, Jane E. Carlson, Reza Saffari, and JeanMarie Houghton

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Contractile effects of adenosine A1 and A2A receptors in isolated murine hearts, Eugene I. Tikh, Richard A. Fenton, and James G. Dobson Jr.

Publications from 2004

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Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception, Ania Busza, Myai Emery-Le, Michael Rosbash, and Patrick Emery

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Identification and activity of a lower eukaryotic serine proteinase inhibitor (serpin) from Cyanea capillata: analysis of a jellyfish serpin, jellypin, Elisabeth B. Cole, David M. Miller, David Rometo, Robert M. Greenberg, Dieter Bromme, Sule Cataltepe, Stephen C. Pak, David R. Mills, Gary A. Silverman, and Cliff J. Luke

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Imaging cocaine-induced changes in the mesocorticolimbic dopaminergic system of conscious rats, Marcelo Febo, Annabell C. Segarra, Jeffrey R. Tenney, Mathew E. Brevard, Timothy Q. Duong, and Craig F. Ferris

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Effect of substrate mechanics on chondrocyte adhesion to modified alginate surfaces, Nicholas G. Genes, Jon A. Rowley, David J. Mooney, and Lawrence J. Bonassar

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Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells, John E. Harris, Kenneth D. Bishop, Nancy E. Phillips, John P. Mordes, Dale L. Greiner, Aldo A. Rossini, and Michael P. Czech

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Gastric cancer originating from bone marrow-derived cells, JeanMarie Houghton, Calin Stoicov, Sachiyo Nomura, Arlin B. Rogers, Jane E. Carlson, Hanchen Li, Xun Cai, James G. Fox, James R. Goldenring, and Timothy C. Wang

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Imaging oxygen consumption in forepaw somatosensory stimulation in rats under isoflurane anesthesia, Zhaohui M. Liu, Karl F. Schmidt, Kenneth M. Sicard, and Timothy Q. Duong

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Molecular biology of gastric cancer: Helicobacter infection and gastric adenocarcinoma: bacterial and host factors responsible for altered growth signaling, Calin Stoicov, Reza Saffari, Xun Cai, Chhaya Hasyagar, and JeanMarie Houghton

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Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections, Calin Stoicov, Mark T. Whary, Arlin B. Rogers, Frederick S. Lee, Kristine Klucevsek, Hanchen Li, Xun Cai, Reza Saffari, Zhongming Ge, Imtiaz A. Khan, Crescent L. Combe, Andrew D. Luster, James G. Fox, and JeanMarie Houghton

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FMRI of brain activation in a genetic rat model of absence seizures, Jeffrey R. Tenney, Timothy Q. Duong, Jean A. King, and Craig F. Ferris

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fMRI of generalized absence status epilepticus in conscious marmoset monkeys reveals corticothalamic activation, Jeffrey R. Tenney, Paul C. Marshall, Jean A. King, and Craig F. Ferris

Publications from 2003

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Correlation between hearing loss and scala media area in guinea pigs with long-standing endolymphatic hydrops, Morgan E. Hott, Martin Graham, Lawrence J. Bonassar, and Cliff A. Megerian

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Helicobacter and gastric cancer disease mechanisms: host response and disease susceptibility, Hanchen Li, Calin Stoicov, Xun Cai, Timothy C. Wang, and JeanMarie Houghton

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Regional cerebral blood flow and BOLD responses in conscious and anesthetized rats under basal and hypercapnic conditions: implications for functional MRI studies, Kenneth M. Sicard, Qiang Shen, Mathew E. Brevard, Ross Sullivan, Craig F. Ferris, Jean A. King, and Timothy Q. Duong

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Corticothalamic modulation during absence seizures in rats: a functional MRI assessment, Jeffrey R. Tenney, Timothy Q. Duong, Jean A. King, Reinhold Ludwig, and Craig F. Ferris

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Activity-dependent trafficking and dynamic localization of zipcode binding protein 1 and beta-actin mRNA in dendrites and spines of hippocampal neurons, Dhanrajan M. Tiruchinapalli, Yuri Oleynikov, Sofija Kelic, Shailesh M. Shenoy, Adam Hartley, Patric K. Stanton, Robert H. Singer, and Gary J. Bassell

Publications from 2002

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The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases, May Al-Khunaizi, Cliff J. Luke, Yuko S. Askew, Stephen C. Pak, David J. Askew, Sule Cataltepe, David M. Miller, David R. Mills, Christopher Tsu, Dieter Bromme, James A. Irving, James C. Whisstock, and Gary A. Silverman

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Redirecting retroviral tropism by insertion of short, nondisruptive peptide ligands into envelope, Timothy J. Gollan and Michael R. Green

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Generation of recombinant vaccinia viruses expressing Puumala virus proteins and use in isolating cytotoxic T cells specific for Puumala virus, Masanori Terajima, Heather Lin Van Epps, Dexin Li, Anita M. Leporati, Sarah E. Juhlin, Jukka Mustonen, Antti Vaheri, and Francis A. Ennis

Publications from 2001

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Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities, Rita Bortell, Joel Moss, Robert C. McKenna, Mark R. Rigby, Dena Niedzwiecki, Linda A. Stevens, Walter A. Patton, John P. Mordes, Dale L. Greiner, and Aldo A. Rossini

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Sequence-specific interaction between HIV-1 matrix protein and viral genomic RNA revealed by in vitro genetic selection, Aruna Purohit, Stefan A. Dupont, Mario Stevenson, and Michael R. Green

Publications from 2000

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A plasticizer released from IV drip chambers elevates calcium levels in neurosecretory terminals, Keith Tully, David Kupfer, Alejandro M. Dopico, and Steven N. Treistman

Publications from 1999

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A novel nuclear export activity in HIV-1 matrix protein required for viral replication, Stefan A. Dupont, Natalia Sharova, Caryn DeHoratius, Ching-man A. Virbasius, Xiaochun Zhu, Alissa G. Bukrinskaya, Mario Stevenson, and Michael R. Green

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Effect of CpG methylation on isotype and magnitude of antibody responses to influenza hemagglutinin-expressing plasmid, David Marc Feltquate and Harriet L. Robinson

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A new isolation method for rat intraepithelial lymphocytes, Derrick James Todd, Amrik J. Singh, Dale L. Greiner, John P. Mordes, Aldo A. Rossini, and Rita Bortell

Publications from 1998

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Ethanol potentiation of calcium-activated potassium channels reconstituted into planar lipid bilayers, Benson Chu, Alejandro M. Dopico, Jose R. Lemos, and Steven N. Treistman

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Wilson disease in 1998: genetic, diagnostic and therapeutic aspects, John L. Gollan and Timothy J. Gollan

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CPEB-mediated cytoplasmic polyadenylation and the regulation of experience-dependent translation of alpha-CaMKII mRNA at synapses, Lin Wu, David G. Wells, Joyce Tay, Duane Mendis, Mary-Alice Abbott, Allan Barnitt, Elizabeth Quinlan, Arnold Heynen, Justin R. Fallon, and Joel D. Richter

Publications from 1997

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Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization, David Marc Feltquate, Shaun Heaney, Robert G. Webster, and Harriet L. Robinson

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DNA immunization for influenza virus: studies using hemagglutinin- and nucleoprotein-expressing DNAs, Harriet L. Robinson, Christine Margaret Boyle, David Marc Feltquate, Merribeth J. Morin, Joseph C. Santoro, and Robert G. Webster

Publications from 1996

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Xenotransplantation of porcine fetal ventral mesencephalon in a rat model of Parkinson's disease: functional recovery and graft morphology, Wendy R. Galpern, Lindsay H. Burns, Terrence W. Deacon, Jonathan H. Dinsmore, and Ole Isacson

Publications from 1995

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Major histocompatibility complex class I-restricted cytotoxic T lymphocyte responses to Epstein-Barr virus in children, Hisashi Tamaki, Brian L. Beaulieu, Mohan Somasundaran, and John L. Sullivan

Publications from 1994

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Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat, David M. Frim, Tara A. Uhler, Wendy R. Galpern, M. Flint Beal, Xandra O. Breakefield, and Ole Isacson

Publications from 1988

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The human H1 histone gene FNC16 is functionally expressed in proliferating HeLa S3 cells and is down-regulated during terminal differentiation in HL60 cells, David G. Collart, Kenneth Lynn Wright, Andre J. Van Wijnen, Anna L. Ramsey-Ewing, Jane B. Lian, Janet L. Stein, and Gary S. Stein