DNA vaccines: vector design, delivery, and antigen presentation

UMMS Affiliation

Department of Pathology; Graduate School of Biomedical Sciences, MD/PhD Program

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Medical Subject Headings

Animals; *Antigen Presentation; Drug Delivery Systems; Drug Design; Genetic Engineering; Genetic Vectors; Humans; Vaccines, DNA


Inoculations with antigen-expressing plasmid DNAs (DNA vaccines) in the production of protective immune responses. Since the initial development of DNA vaccines more than 5 years ago, major strides have been made in the design of efficient vaccine vectors and in the process of vaccine delivery. However, many questions remain regarding the mechanism of cellular transfection and in the development of immune responses. This review addresses functional aspects of DNA vaccines, including vector design and delivery, as well as cellular transfection and antigen presentation.

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Citation: J Cell Biochem Suppl. 1998; Vol. 72, S30-31:304-11.

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