The role of innate immune pathways in type 1 diabetes pathogenesis.
Department of Medicine, Division of Diabetes; Graduate School of Biomedical Sciences, MD/PhD Program
Medical Subject Headings
Diabetes Mellitus, Type 1; Immunity, Innate
PURPOSE OF REVIEW: Type 1 diabetes (T1D) is an autoimmune disease typically believed to result from malfunctions in adaptive immune response signaling which result in activation of self-reactive T cells. However, recent research has indicated components of the innate immune response as having a key role in the initiation of the autoimmune process of T1D. This review will highlight recent studies which examined the role of innate immune response signaling and the connections to T1D pathogenesis.
RECENT FINDINGS: Investigations indicate that components of innate immunity, including inflammation and Toll-like receptor signaling, are involved in pancreatic islet infiltration and insulitis. Recent studies examining the role of viral infections in T1D development also implicate innate immune response signaling in disease pathogenesis.
SUMMARY: Current research indicates that components of innate immune response signaling are involved in the initiation of the autoimmune process which results in the eventual destruction of beta cells during T1D pathogenesis. Continuing efforts by researchers to uncover the molecular pathways of innate immunity linked to T1D development could potentially lead to therapeutics capable of preventing and curing the autoimmune disease.
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Citation: Current Opinion in Endocrinology, Diabetes and Obesity 2010 Apr;17(2):126-30.
Pino, Steven C.; Kruger, Annie J.; and Bortell, Rita, "The role of innate immune pathways in type 1 diabetes pathogenesis." (2010). MD/PhD Program. 12.