The Interdisciplinary Graduate Program (IGP) is an academic program of the Graduate School of Biomedical Sciences (GSBS) at the University of Massachusetts Medical School. The program was established to support interdisciplinary approaches to graduate training in biomedical research. This collection showcases publications and presentations authored by students in this program.

Attention GSBS Interdisciplinary Graduate Program students: To submit your publications, go to GSBS Student Publications and click on Submit Research in the left sidebar. You’ll need to log in or create a free account. If you have the article's PubMed ID, submission is very easy. Enter the PubMed ID and information from PubMed will be used to populate the submission form. Questions? Contact Lisa Palmer.

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Publications from 2010

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Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway, Megha Ghildiyal, Jia Xu, Herve Seitz, Zhiping Weng, and Phillip D. Zamore

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Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling, Pearl Gray, Kathrin S. Michelsen, Cherilyn M. Sirois, Emily Lowe, Kenichi Shimada, Timothy R. Crother, Shuang Chen, Constantinos Brikos, Yonca Bulut, Eicke Latz, David Underhill, and Moshe Arditi

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The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer, Ma Reina D. Improgo, Michael D. Scofield, Andrew R. Tapper, and Paul D. Gardner

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From smoking to lung cancer: the CHRNA5/A3/B4 connection, Ma. Reina D. Improgo, Michael D. Scofield, Andrew R. Tapper, and Paul D. Gardner

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CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion, Ming-Chung Kan, Aparna Oruganty-Das, Amalene Cooper-Morgan, Guang Jin, Sharon A. Swanger, Gary J. Bassell, Harvey M. Florman, Klaus van Leyen, and Joel D. Richter (Molecular and cellular biology)

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Structure and function of nematode RNA-binding proteins, Ebru Kaymak, LiangMeng Wee, and Sean P. Ryder

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Insertion of tetracysteine motifs into dopamine transporter extracellular domains, Deanna M. Navaroli and Haley E. Melikian

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The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe, Samriddha Ray, Kazunori Kume, Sneha Gupta, Wanzhong Ge, Mohan Balasubramanian, Dai Hirata, and Dannel McCollum

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A transcriptional regulatory element critical for CHRNB4 promoter activity in vivo, Michael D. Scofield, Andrew R. Tapper, and Paul D. Gardner

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Bi-specific MHC heterodimers for characterization of cross-reactive T cells, Zu T. Shen, Michael A. Brehm, Keith A. Daniels, Alexander B. Sigalov, Liisa K. Selin, Raymond M. Welsh, and Lawrence J. Stern

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IFI16 is an innate immune sensor for intracellular DNA, Leonie Unterholzner, Sinead E. Keating, Marcin Baran, Kristy A. Horan, Soren B. Jensen, Shrutie Sharma, Cherilyn M. Sirois, Tengchuan Jin, Eicke Latz, T. Sam Xiao, Katherine A. Fitzgerald, Soren R. Paludan, and Andrew G. Bowie

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Isoform-specific regulation of Akt signaling by the endosomal protein WDFY2., Helena A. Walz, Xiarong Shi, My T. Chouinard, Catherine A. Bue, Deanna M. Navaroli, Akira Hayakawa, Qiong L. Zhou, Jonathan Nadler, Deborah Marie Leonard, and Silvia Corvera

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Rescue of HIV-1 Release by Targeting Widely Divergent NEDD4-Type Ubiquitin Ligases and Isolated Catalytic HECT Domains to Gag, Eric R. Weiss, Elena Popova, Hikaru Yamanaka, Hyung Cheol Kim, Jon M. Huibregtse, and Heinrich G. Göttlinger

Publications from 2009

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A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development, Laurence D. Covassin, Arndt F. Siekmann, Michael C. Kacergis, Elizabeth Laver, John C. Moore, Jacques A. Villefranc, Brant M. Weinstein, and Nathan D. Lawson

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Prevalence and clinical characteristics of right ventricular dysfunction in transient stress cardiomyopathy, Timothy P. Fitzgibbons, Christopher Madias, Seth Adhar, Joseph L. Bouchard, Jeffrey T. Kuvin, Ayan R. Patel, Natesa G. Pandian, Theo E. Meyer, Gerard P. Aurigemma, and Dennis A. Tighe

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Mortality in diastolic heart failure: an update, Timothy P. Fitzgibbons, Theo E. Meyer, and Gerard P. Aurigemma

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A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation., Srivatsan Padmanabhan, Arnab Mukhopadhyay, Sri Devi Narasimhan, Gregory J. Tesz, Michael P. Czech, and Heidi A. Tissenbaum

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Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas, Michael J. Parsons, Harshan Pisharath, Shamila Yusuff, John C. Moore, Arndt F. Siekmann, Nathan D. Lawson, and Steven D. Leach

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The C. elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors, John S. Reece-Hoyes, Bart Deplancke, M. Inmaculada Barrasa, Julia Hatzold, Ryan B. Smit, H. Efsun Arda, Patricia A. Pope, Jeb Gaudet, Barbara Conradt, and Albertha J. M. Walhout

Publications from 2008

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Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi, Daniella C. Bartholomeu, Catherine Ropert, Mariane B. Melo, Peggy Parroche, Caroline F. Junqueira, Santuza M. R. Teixeira, Cherilyn M. Sirois, Pia Kasperkovitz, Cathrine F. Knetter, Egil Lien, Eicke Latz, Douglas T. Golenbock, and Ricardo T. Gazzinelli

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IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease, Elaine M. Castilow, David K. Meyerholz, and Steven Michael Varga

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The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells, Kathryn L. Lipson, Rajarshi Ghosh, and Fumihiko Urano

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Long-range chromosomal interactions and gene regulation, Angela Miele and Job Dekker

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Preferential utilization of Imp7/8 in nuclear import of Smads, Xiaohao Yao, Xiaochu Chen, Charisa L. Cottonham, and Lan Xu

Publications from 2007

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Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1, Klaus Forstemann, Michael D. Horwich, LiangMeng Wee, Yukihide Tomari, and Phillip D. Zamore

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Pathophysiology of respiratory failure following acute dichlorvos poisoning in a rodent model, Romolo Joseph Gaspari and David Paydarfar

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Ligand-induced conformational changes allosterically activate Toll-like receptor 9, Eicke Latz, Anjali Verma, Alberto Visintin, Mei Gong, Cherilyn M. Sirois, Dionne C. G. Klein, Brian G. Monks, C. James McKnight, Marc S. Lamphier, W. Paul Duprex, Terje Espevik, and Douglas T. Golenbock

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p53-independent abrogation of a postmitotic checkpoint contributes to human papillomavirus E6-induced polyploidy, Yingwang Liu, Susan Ann Heilman, Diego Illanes, Greenfield Sluder, and Jason J. Chen

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Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE, Jane Tian, Ana Maria Avalos, Su-Yau Mao, Bo Chen, Kannaki Senthil, Herren Wu, Peggy Parroche, Stacey Drabic, Douglas T. Golenbock, Cherilyn M. Sirois, Jing Hua, Ling Ling An, Laurent Audoly, Greg La Rosa, Angelika Bierhaus, Peter Naworth, Ann Marshak-Rothstein, Mary K. Crow, Katherine A. Fitzgerald, Eicke Latz, Peter A. Kiener, and Anthony J. Coyle

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Matrix and Steiner-triple-system smart pooling assays for high-performance transcription regulatory network mapping, Vanessa Vermeirssen, Bart Deplancke, M. Inmaculada Barrasa, John S. Reece-Hoyes, H. Efsun Arda, Christian A. Grove, Natalia Julia Martinez, Reynaldo Sequerra, Lynn Doucette-Stamm, Michael R. Brent, and Albertha J. M. Walhout

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Gateway compatible vectors for analysis of gene function in the zebrafish, Jacques A. Villefranc, Julio D. Amigo, and Nathan D. Lawson

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Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads, Lan Xu, Xiaohao Yao, Xiaochu Chen, Peiyuan Lu, Biliang Zhang, and Y. Tony Ip

Publications from 2006

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Keystone meeting summary: 'Adipogenesis, obesity, and inflammation' and 'Diabetes mellitus and the control of cellular energy metabolism, ' January 21-26, 2006, Vancouver, Canada, Silvia Corvera, Alison Burkart, Ja-Young Kim, Jennifer L. Christianson, Zhao Wang, and Philipp E. Scherer

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Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish, Laurence D. Covassin, Jacques A. Villefranc, Michael C. Kacergis, Brant M. Weinstein, and Nathan D. Lawson

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Control of cellular senescence by CPEB, Irina Groisman, Maria Ivshina, Veronica Marin, Norman J. Kennedy, Roger J. Davis, and Joel D. Richter

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TLR9 and the recognition of self and non-self nucleic acids, Marc S. Lamphier, Cherilyn M. Sirois, Anjali Verma, Douglas T. Golenbock, and Eicke Latz

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ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose), Alan R. Morrison, Joel Moss, Linda A. Stevens, James E. Evans, Caitlin Farrell, Eric Lee Merithew, David G. Lambright, Dale L. Greiner, John P. Mordes, Aldo A. Rossini, and Rita Bortell

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Epigenetic telomere protection by Drosophila DNA damage response pathways, Sarah R. Oikemus, Joana Queiroz-Machado, KuanJu Lai, Nadine Schultz, Claudio E. Sunkel, and Michael H. Brodsky

Publications from 2005

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Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein, Klaus Forstemann, Yukihide Tomari, Tingting Du, Vasily V. Vagin, Ahmet M. Denli, Diana P. Bratu, Carla Andrea Klattenhoff, William E. Theurkauf, and Phillip D. Zamore

Publications from 2004

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Tissue pH determination for the detection of metabolically active, inflamed vulnerable plaques using near-infrared spectroscopy: an in-vitro feasibility study, Tania N. Khan, Babs R. Soller, Morteza Naghavi, and Ward Casscells

Publications from 2003

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Rad54p is a chromatin remodeling enzyme required for heteroduplex DNA joint formation with chromatin, Mariela Jaskelioff, Stephen Van Komen, Jocelyn E. Krebs, Patrick Sung, and Craig L. Peterson

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The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase, Thomas H. Lee, Qiaojia Huang, Sarah R. Oikemus, Jennifer Shank, Juan-Jose Ventura, Nicole Cusson, Richard R. Vaillancourt, Bing Su, Roger J. Davis, and Michelle Kelliher

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Investigation of muscle pH as an indicator of liver pH and injury from hemorrhagic shock, Babs R. Soller, Tania N. Khan, Janice Favreau, Charles Hsi, Juan Carlos Puyana, and Stephen O. Heard

Publications from 2002

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TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2, Susan J. Hayes, Anil Chawla, and Silvia Corvera

Publications from 2001

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Simultaneous measurement of hepatic tissue pH, venous oxygen saturation and hemoglobin by near infrared spectroscopy, Babs R. Soller, Ndumiso A. Cingo, Juan Carlos Puyana, Tania N. Khan, Charles Hsi, H Kim, Janice Favreau, and Stephen O. Heard

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Application of fiberoptic sensors for the study of hepatic dysoxia in swine hemorrhagic shock, Babs R. Soller, Stephen O. Heard, Ndumiso A. Cingo, Charles Hsi, Janice Favreau, Tania N. Khan, Randy R. Ross, and Juan Carlos Puyana

Publications from 1999

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Endotoxin-induced inhibition of growth hormone receptor signaling in rat liver in vivo, Yilei Mao, Pei-Ra Ling, Timothy P. Fitzgibbons, Karen C. McCowen, G. Peter Frick, Bruce R. Bistrian, and Robert J. Smith