GSBS Dissertations and Theses

 

Since the school's inception in 1979, students in the University of Massachusetts Medical School's Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

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Publications from 1994

Identification and Characterization of the Murine Germline Immunoglobulin Heavy Chain Epsilon Constant Region Promoter, Sandra Ann Delphin

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Signal Transduction Mechanisms for the Stimulation of Lipolysis by Growth Hormone: A Dissertation, Rupert G. Yip

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Studies on the Mechanism of Deoxycytidylate Hydroxymethylase from Bacteriophage T4: A Dissertation, Karen Lorraine Graves

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Transcriptional Regulation by the SACCHAROMYCES CEREVISIAE Centromere-Binding Protein CP1: a Dissertation, Kevin F. O'Connell

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Human Immunodeficiency Virus Type-1 Infection of Human Myeloid Cells, Cynthia Ann Pise-Masison

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Molecular Determinants of GLUT1: Structure and Function: A Dissertation, Ralph J. Zottola

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Osteoclast Ontogeny-Experimental Studies in Two Osteopetrotic Mutations in the Rat: A Dissertation, Matthew Joseph Cielinski

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A Mutational Analysis of Structural Determinants Within the Newcastle Disease Virus Fusion Protein: a Dissertation, Julie N. Reitter

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Analysis of Temperature Sensing in Yersinia pestis: A Dissertation, Nancy Palme Hoe

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Cloning, Expression and Regulation of CYP3A10, a Hamster Liver Cytochrome P450 Involved in Lithocholic Acid and Steroid 6β-Hydroxylation: a Dissertation, Jose Manuel Teixeira

Publications from 1993

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Analysis of and Role for Effector and Target Cell Structures in the Regulation of Virus Infections by Natural Killer Cells: a Dissertation, Randy R. Brutkiewicz

Cytotoxic T lymphocyte specificities during the acute and memory responses to lymphocytic choriomeningitis virus infection : ‡b a dissertation, Sharon R. Nahill

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Regulation of IgA Class Switch Recombination in the I.29μ B Cell Lymphoma by Cytokines and Inhibitors of Poly(ADP-ribose) Polymerase: A Thesis, Penny E. Shockett

Analysis of CD45 Alternative Exon Expression in Murine and Human CD4+ T Cell Subpopulations: a Thesis, Paul R. Rogers

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sieB and esc genes of Bacteriophage P22: A Dissertation, Koustubh Ranade

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Transport of Nucleotide Derivatives into Endoplasmic Reticulum and Golgiapparatus Derived Vesicles: a Dissertation, Caroline A. Clairmont

Metabolic Regulation of Glucose Transport is an Insulin-Dependent Mechanism: A Dissertation, Deborah L. Diamond

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Virus-Host Interactions in the Development of Avian Leukosis Virus-Induced Osteopetrosis: a Dissertation, Rosalinda Gram Foster

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Regulation of δ-Aminolevulinic Acid Synthase and Heme Oxygenase in Cultured Chick Embryo Liver Cells: Synergistic Induction of Both Enzymes by Glutathimide and Iron and Repression of δ-Aminolevulinic Acid Synthase by Metalloporphyrins and Heme: A Dissertation, Edward Earl Cable

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Dynamics of Neuron-Specific Gene Expression During Development and in Response to Selective Lesions of the Rat Central Nervous System: A Dissertation, Richard H. Melloni

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Nuclear Structure Studied by Fluorescence Hybridization: Visualization of Individual Gene Transcription and RNA Splicing: A Thesis, Yigong P. Xing

Analysis of the EGF Receptor Homologue in Drosophila: a Thesis, Sandra Marie McNeil

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Genetic Analysis of the Saccharomyces Cerevisiae Centromere-Binding Protein CP1: a Thesis, Daniel C. Masison

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HIV-1 Sequences in the Establishment of Chronic Virus Producers: a Thesis, Farah Mustafa

Publications from 1992

Functional Analysis of the c-MYC Transactivation Domain: A Dissertation, Alpna Seth

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Development and Application of Ultrastructural in Situ Hybridization to Visualize the Spatial Organization of mRNA: a Dissertation, Gary J. Bassell

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Characterization of the Hypersensitive Response of Glycogen Phosphorylase to Catecholamine Stimulation in Primary Culture Diabetic Cardiomyocytes: A Thesis, Jo Ann Buczek-Thomas

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Structure and Function of Cytoplasmic Dynein: a Thesis, Bryce M. Paschal

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Distinct Permissive Pathways Mediate the Effects of Nerve Growth Factor and Lithium on Neurotensin/Neuromedin N Gene Expression in PC12 Cells: A Thesis, Bryant Paul Bullock

DNA Sequences Involved in Immunoglobulin Germ-line C [alpha] Gene Transcription: a Thesis, Yi-chaung A. Lin

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Probing the dNTP Binding Region of Bacillus subtilis: DNA Polymerase III with Site-Directed Inhibitors: A Dissertation, Michelle Marie Butler

Publications from 1991

Ribosome Binding to the Mammalian Endoplasmic Reticulum: A Thesis, Paula Grosse Collins

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Glucose Transporter Oligomeric Structure Determines the Mechanism of Glucose Transport: A Dissertation, Daniel N. Hebert

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Repair of DNA Containing Small Heterologous Sequences by Escherichia Coli: a Dissertation, Breck Olland Parker

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Small B Cells as Antigen Presenting Cells in the Induction of Tolerance to Soluble Protein Antigens: A Dissertation, Elizabeth E. Eynon

Signal Transduction by the Epidermal Growth Factor Receptor: a Dissertation, Ingrid C. Northwood

Regulation of Polarization and Chemotaxis in Newt Eosinophils: The Role of Calcium: A Dissertation, Rodney Arthur Brundage

Analysis of B Cell Immediate Early Gene Expression in Response to Contact Dependent T Cell Help and Anti-immunoglobulins: a Thesis, Stephen J. Klaus

The Human Synapsin I Gene: Linkage Mapping on the X Chromosome: A Dissertation, Cordula U. Kirchgessner

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Transcriptional Control of Human Histone Gene Expression: Delineation and Regulation of Protein/DNA Interactions: A Thesis, Andre John van Wijnen

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Regulation of Transcription of Mouse Immunoglobulin Germ-Line γ1 RNA: Structural Characterization of Germ-Line γ1 RNA and Molecular Analysis of the Promoter: A Dissertation, Minzhen Xu

G Protein Interactions with the Substance P Receptor in Rat Submaxillary Gland: a Dissertation, Susan G. Macdonald

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Virus-Lymphocyte Interactions: Virus Expression Is Differentially Modulated by B Cell Activation Signals: A Dissertation, Madelyn R. Schmidt

Publications from 1990

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Role of Recurrent Hydrophobic Residues in Catalyzing Helix Formation by T Cell-Presented Peptides: a Thesis, Shan Lu

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Functional and Structural Characterization of a Human H4 Histone Gene Promoter: a Thesis, Kenneth Lynn Wright

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The Structure, Function, and Regulation of Insulin-like Growth factor II/Mannose 6-phosphate Receptor Forms: a Thesis, Kevin B. Clairmont

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Regulation of β-Adrenergic-Induced Protein Phosphorylation in the Myocardium: A Dissertation, Edward E. George

Fatty Acids Directly Activate K+ Channels in Isolated Gastric and Vascular Smooth Muscle Cells: A Dissertation, Richard W. Ordway

Molecular Biology of Herpesvirus Ateles: A Thesis, David Bruce DeGrand

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Mutually Dependent Elements in the Neurotensin/Neuromedin N Gene Promoter Integrate Multiple Environmental Stimuli in PC12 Cells: a Thesis, Edward H. Kislauskis

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Genetic Analysis of the Saccharomyces Cerevisiae Pheromone Response Pathway: a Thesis, Dmitry B. Blinder

The Control of Maternal Messenger RNA Expression During the Early Development of Xenopus laevis: A Thesis, Laura Lynn McGrew

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The Stimulation of Luteinizing Hormone Secretion from Anterior Pituitary Cells in Culture by Substance P: A Dissertation, Maureen Shamgochian

Regulation of Prostaglandin Biosynthesis by Estrogen and Progesterone in Simian and Ovine Endometrium: a Thesis, Joyce A. Eldering

Identification and Characterization of the Virulence Determinant of the 9.5 Kilobase Plasmid of Yersinia Pestis: a Thesis, Olanrewaju A. Sodeinde

Publications from 1989

Characterization of the Gene and Messages for Vasoactive Intestinal Polypeptide in Rat and Mouse: a Thesis, Edward D. Lamperti

The Role of Guanine Ribonucleotides in Protein Translocation Across the Mammalian Endoplasmic Reticulum: a Thesis, Timothy J. Connolly

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Development of Selective Inhibitors of DNA Polymerase Delta: A Thesis, Robert Vincent Talanian

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Proteolytic Cleavages of Molecules Involved in Antigen Processing and Presentation: A Thesis, Lawrence James Thomas

Genetic Structure of the Bacteriophage P22 PL Operon: A Thesis, Arlene Semerjian

A Molecular Analysis of Selenium Incorporation into Glutathione Peroxidase: Stop Is Not the End: A Thesis, Sunil Chada

Mouse Antibody Response to Group A Streptococcal Carbohydrate: A Thesis, Christopher D. Jarvis

The Membrane Integration of the Hemagglutinin-Neuraminidase Glycoprotein of Newcastle Disease Virus: A Thesis, Cheryl Anne Wilson

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Plasma Membrane Processes in Smooth Muscle: Characterization of Ca2+ Transport and Muscarinic Cholinergic Receptors: A Thesis, Pamela A. Lucchesi

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Structural Determinants of mRNA Turnover in Yeast: a Thesis, David Herrick

Publications from 1988

Interactions between Growth Hormone and the Mechanisms Controlling Arterial Pressure and Renin Secretion in the Rat: A Thesis, Claude Demosthene Simon

Mutations of the Alpha-Subunit of G-Proteins: A Thesis, Chee-Wai Woon

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MYC and E1A Oncogenes Alter the Response of PC12 Cells to Nerve Growth Factor and Block Differentiation: A Thesis, Susan C. Schiavi

Phenotypic and Biochemical Characterization of Cells Expressing a Gas/Gai Chimeric Protein: a Thesis, Charles Nicholas Sidhartha Soparkar

The Cellular Immune Response to Epstein-Barr Virus during Active Infectious Mononucleosis: a Thesis, Blake E. Tomkinson

A Genetic Analysis of RNA Polymerase-Promoter Interactions: A Thesis, Thomas James Gardella

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Characterization of Antigen-Specific Antigen Processing by the Resting B cell: a Thesis, Edmund J. Gosselin

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A Genetic and Structural Analysis of P22 Lysozyme: A Thesis, Dale Rennell

Publications from 1987

Characterization of the Two Non-Allelic Preproinsulin Genes in Mice: a Thesis, Bruce Martin Wentworth

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Cytotoxic Lymphocytes in Viral Hepatitis: a Thesis, Kim W. McIntyre

Cellular mechanism of neutrophil chemotaxis: the role of CA+2, as viewed with the fluorescent dye, FURA-2, in the polarization of human polymorphonuclear leukocytes following stimulation with the chemoattractant, F-Methionyl-Leucyl-Phenylalanine: a thesis, Mary Scanlon

Publications from 1986

An Analysis of the Reversible Phosphorylation of Glycogen Synthase in Rat Heart: a Dissertation, Charles Daniel Wolleben

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Biochemical Studies on the Hemolymph Trypsin Inhibitors of the Tobacco Hornworm Manduca Sexta: A Thesis, Narayanaswamy Ramesh

Publications from 1985

Tn1 Insertions in the 3' Untranslated Region of the ant Operon of Bacteriophage P22 Affect ant Gene Expression and Alter ant mRNA Stability: a Thesis, Linda McMahan

Publications from 1984

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The Role of Natural Killer Cells and Interferon in Virus Infections: A Thesis, Jack F. Bukowski

Expression of the Class II Antigen-Associated Invariant Chain in Leukemic and Virally Transformed Cells, Robert Christopher Spiro