Since the school's inception in 1979, students in the University of Massachusetts Medical School's Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

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Publications from 1998

Characterization of a Deletion in erb [subscript erb]B Sequences Associated with Angiosarcoma: a Thesis, Sharon Elizabeth Tracy

The ADA/GCN5 Containing Acetyltransferase Complexes of Saccharomyces cerevisiae: Roles in Antagonizing Chromatin Mediated Transcriptional Repression: A Dissertation, Kerri Jeanne Pollard

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DNA Immunization: Role of Target Site, Bone Marrow-Derived Cells and Secretion of Antigen in the Initiation of Immune Responses: A Dissertation, Celia Aurora Tiglao Torres

CD40 Sustains T Cell Activation During Cognate Communication with Resting B Cells: a Dissertation , Dean E. Evans

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Role of MAP Kinases in the Induction of Heme Oxygenase-1 by Arsenite: Studies in Chicken Hepatoma Cells: A Dissertation, Kimberly Kirstin Elbirt

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Structural Association of XIST RNA with Inactive Chromosomes in Somatic Cells : a Key Step in the Process that Establishes and Faithfully Maintains X-inactivation, Christine Moulton Clemson

Human Cellular Immune Responses to Dengue Virus Infection: Potential Roles in Immunopathology, Susan J. Gagnon

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Transcriptional Regulation of a Human H4 Histone Gene is Mediated by Multiple Elements Interacting with Similar Transcription Factors: A Dissertation, Thomas J. Last

Development of the Antibiotic Potential of a Unique Family of DNA Polymerase Inhibitors, Paul M. Tarantino,

The Osteocalcin Gene: Transcriptional Elements and Factors Regulating TGF-β1 Responsiveness and Tissue-Specific Expression in Bone Cells: A Dissertation, Chaitali Banerjee

Helper T Cell Differentiation in DNA-Immunized Mice: A Dissertation, David Marc Feltquate

Cloning, Characterization and Functional Analysis of TPR, an Oncogene-Activating Protein of the Nuclear Pore Complex: A Dissertation, Peter Lawrence Bangs

Mechanism of inhibition of B family DNA polymerases by N²-([rho]-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate, BuPdGTP: A Dissertation, James Michael Walker Stattel

Envelope Determinants of HIV-1 Cytopathicity, Serene E. Forte

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Analysis of the Mechanism of Ras Activation: Mapping of Important Functional Domains of the Son of Sevenless Protein, Linda Sue McCollam-Guilani

Crystallographic Studies of the Pathological Polymerization of Human Hemoglobin, Daniel John Harrington

T Cell Receptor-Dependent and Independent Events During Potent Anti-Viral T Cell Responses, Christopher C. Zarozinski

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Cloning and Characterization of Dynamitin, the 50 kDa Subunit of Dynactin: A Study of Dynactin and Cytoplasmic Dynein Function in Vertebrates, Christophe de Jesus Echeverri

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Genetic and Biochemical Analysis of the Activation Mechanism of the Saccharomyces Cerevisiae Pheromone Receptor, Gul H. Bukusoglu

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Analysis of TAF II Function in the Yeast Saccharomyces Cerevisiae, Lynne Marie Apone

The Ability of CD40L, but not LPS, to Induce Germline Immunoglobulin γ1 Transcripts Is Explained by Differential Induction of NF-κB/Rel Proteins , Shih-Chang Lin

Publications from 1997

HIV-1 and SIVmac Repression by Retinoic Acid in Monocyte Cell Lines and Macrophages, and HIV-1 Repression by Interleukin-16 in T Cell Lines: A Dissertation, Joseph Walter Maciaszek

The c-Jun NH₂-Terminal Kinase Regulates Jun in vitro and in vivo during the Process of Dorsal Closure: A Dissertation, Hayla Karen Sluss

Mechanism of Fatty Acid Modulation of Calcium-Activated Potassium Channel Activity, Alison L. Clarke

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An Examination of the Hypothalamo-neurohypophysial System of the Rat: Restoration of the Vasopressinergic System, Lynn M. DiBenedetto

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Studies of Leishmania major Pteridine Reductase 1, a Novel Short Chain Dehydrogenase, James Luba

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In Vivo Functional Analysis of the Saccharomyces Cerevisiae SWI/SNF Complex: A Dissertation, Loree Griffin Burns

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In Vivo Regulation of Murine Cytomegalovirus Infections: The Role of Cell Surface Molecules and Mechanisms of Control by Natural Killer Cells: A Dissertation, Chin Hun Tay

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Contribution of Ordered Water Molecules and a Crucial Phenylalanine to Cooperative Pathway(s) in Scapharca Dimeric Hemoglobin: a Dissertation, Animesh Dev Pardanani

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Molecular Basis of the Mechanism and Regulation of Receptor-GTP Binding Protein Interactions: A Thesis, Marianne Wessling-Resnick

The Role of Ca2+ Channel Subunit Composition in G Protein-Mediated Inhibition of Ca2+ Channels: a Disstertation, John Patrick Roche

Publications from 1996

Signal Transduction by the EGF Receptor in Normal and Transformed Cells: a Dissertation, Cherie A. Taglienti

Characterization of DNA-Protein Interactions at the NT/N Promoter: Proles for AP-1 and ATF Proteins, Gerard P. McNeil

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Mismatch Repair Acts As a Barrier to Homeologous Recombination in Saccharomyces cerevisiae: A Dissertation, Erica Marie Selva

A Potential Role for the 70 kD Heat Shock Cognate Protein in Receptor Endocytosis, Victor Lazaron

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Neuroprotection and Neurotransplantation Strategies in Models of Parkinson’s Disease, Wendy R. Galpern

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Cytotoxic T-Lymphocyte Responses During Acute Epstein-Barr Virus Infection, Brian L. Beaulieu

Dissection of Lymphocyte Activation: Defining a Role for PI-3 Kinase, David Alan Hartley

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Analysis of Low Zone Tolerance in Normal and B Cell-Deficient Mice, Allison Michelle Baird

Publications from 1995

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Type-Specific Immunity in HIV-1 Vertically Infected Infants, Cheryl A. Pikora

R T 6: a Bifunctional Protein of Regulatory T Cells, Mark R. Rigby

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Chromatin Structure of the Rat Osteocalcin Gene Promoter in Bone-Derived Cells, Martin A. Montecino

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Molecular Characterization of Mitofilin, a Novel, Mitochondrial, Coiled Coil Protein, and the Relationship Between Organism Complexity and Coiled Coil Protein-Mediated Structure: A Dissertation, Paul R. Odgren

Tolerance Induction to a Foreign Protein Antigen: Analysing the Role of B Cells in Establishing Peripheral Tolerance, Victoria Nicole Yuschenkoff

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Cloning and Cell Cycle Analysis of NuMA, a Phosphoprotein That Oscillates Between the Nucleus and the Mitotic Spindle, Cynthia A. Sparks

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The Role of T Lymphocytes in the hu-PBMC-SCID Mouse Model of Epstein-Barr Virus-Associated Lymphoproliferative Disease, Mary A. Cromwell

The Characterization of Staphylococcus Aureus polC: the Structural Gene for DNA Polymerase III, Diane Frances Pacitti

Publications from 1994

T Lymphocyte Apoptosis and Memory in Viral Infection: A Dissertation, Enal Shahid Razvi

Identification and Characterization of the Murine Germline Immunoglobulin Heavy Chain Epsilon Constant Region Promoter, Sandra Ann Delphin

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Signal Transduction Mechanisms for the Stimulation of Lipolysis by Growth Hormone: A Dissertation, Rupert G. Yip

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Studies on the Mechanism of Deoxycytidylate Hydroxymethylase from Bacteriophage T4: A Dissertation, Karen Lorraine Graves

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Transcriptional Regulation by the SACCHAROMYCES CEREVISIAE Centromere-Binding Protein CP1: a Dissertation, Kevin F. O'Connell

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Human Immunodeficiency Virus Type-1 Infection of Human Myeloid Cells, Cynthia Ann Pise-Masison

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Molecular Determinants of GLUT1: Structure and Function: A Dissertation, Ralph J. Zottola

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Osteoclast Ontogeny-Experimental Studies in Two Osteopetrotic Mutations in the Rat: A Dissertation, Matthew Joseph Cielinski

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A Mutational Analysis of Structural Determinants Within the Newcastle Disease Virus Fusion Protein: a Dissertation, Julie N. Reitter

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Analysis of Temperature Sensing in Yersinia pestis: A Dissertation, Nancy Palme Hoe

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Cloning, Expression and Regulation of CYP3A10, a Hamster Liver Cytochrome P450 Involved in Lithocholic Acid and Steroid 6β-Hydroxylation: a Dissertation, Jose Manuel Teixeira

Publications from 1993

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Analysis of and Role for Effector and Target Cell Structures in the Regulation of Virus Infections by Natural Killer Cells: a Dissertation, Randy R. Brutkiewicz

Cytotoxic T lymphocyte specificities during the acute and memory responses to lymphocytic choriomeningitis virus infection : ‡b a dissertation, Sharon R. Nahill

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Regulation of IgA Class Switch Recombination in the I.29μ B Cell Lymphoma by Cytokines and Inhibitors of Poly(ADP-ribose) Polymerase: A Thesis, Penny E. Shockett

Analysis of CD45 Alternative Exon Expression in Murine and Human CD4+ T Cell Subpopulations: a Thesis, Paul R. Rogers

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sieB and esc genes of Bacteriophage P22: A Dissertation, Koustubh Ranade

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Transport of Nucleotide Derivatives into Endoplasmic Reticulum and Golgiapparatus Derived Vesicles: a Dissertation, Caroline A. Clairmont

Metabolic Regulation of Glucose Transport is an Insulin-Dependent Mechanism: A Dissertation, Deborah L. Diamond

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Virus-Host Interactions in the Development of Avian Leukosis Virus-Induced Osteopetrosis: a Dissertation, Rosalinda Gram Foster

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Regulation of δ-Aminolevulinic Acid Synthase and Heme Oxygenase in Cultured Chick Embryo Liver Cells: Synergistic Induction of Both Enzymes by Glutathimide and Iron and Repression of δ-Aminolevulinic Acid Synthase by Metalloporphyrins and Heme: A Dissertation, Edward Earl Cable

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Dynamics of Neuron-Specific Gene Expression During Development and in Response to Selective Lesions of the Rat Central Nervous System: A Dissertation, Richard H. Melloni

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Nuclear Structure Studied by Fluorescence Hybridization: Visualization of Individual Gene Transcription and RNA Splicing: A Thesis, Yigong P. Xing

Analysis of the EGF Receptor Homologue in Drosophila: a Thesis, Sandra Marie McNeil

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Genetic Analysis of the Saccharomyces Cerevisiae Centromere-Binding Protein CP1: a Thesis, Daniel C. Masison

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HIV-1 Sequences in the Establishment of Chronic Virus Producers: a Thesis, Farah Mustafa

Publications from 1992

Functional Analysis of the c-MYC Transactivation Domain: A Dissertation, Alpna Seth

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Development and Application of Ultrastructural in Situ Hybridization to Visualize the Spatial Organization of mRNA: a Dissertation, Gary J. Bassell

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Characterization of the Hypersensitive Response of Glycogen Phosphorylase to Catecholamine Stimulation in Primary Culture Diabetic Cardiomyocytes: A Thesis, Jo Ann Buczek-Thomas

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Structure and Function of Cytoplasmic Dynein: a Thesis, Bryce M. Paschal

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Distinct Permissive Pathways Mediate the Effects of Nerve Growth Factor and Lithium on Neurotensin/Neuromedin N Gene Expression in PC12 Cells: A Thesis, Bryant Paul Bullock

DNA Sequences Involved in Immunoglobulin Germ-line C [alpha] Gene Transcription: a Thesis, Yi-chaung A. Lin

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Probing the dNTP Binding Region of Bacillus subtilis: DNA Polymerase III with Site-Directed Inhibitors: A Dissertation, Michelle Marie Butler

Publications from 1991

Ribosome Binding to the Mammalian Endoplasmic Reticulum: A Thesis, Paula Grosse Collins

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Glucose Transporter Oligomeric Structure Determines the Mechanism of Glucose Transport: A Dissertation, Daniel N. Hebert

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Repair of DNA Containing Small Heterologous Sequences by Escherichia Coli: a Dissertation, Breck Olland Parker

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Small B Cells as Antigen Presenting Cells in the Induction of Tolerance to Soluble Protein Antigens: A Dissertation, Elizabeth E. Eynon

Signal Transduction by the Epidermal Growth Factor Receptor: a Dissertation, Ingrid C. Northwood

Regulation of Polarization and Chemotaxis in Newt Eosinophils: The Role of Calcium: A Dissertation, Rodney Arthur Brundage

Analysis of B Cell Immediate Early Gene Expression in Response to Contact Dependent T Cell Help and Anti-immunoglobulins: a Thesis, Stephen J. Klaus

The Human Synapsin I Gene: Linkage Mapping on the X Chromosome: A Dissertation, Cordula U. Kirchgessner

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Transcriptional Control of Human Histone Gene Expression: Delineation and Regulation of Protein/DNA Interactions: A Thesis, Andre John van Wijnen

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Regulation of Transcription of Mouse Immunoglobulin Germ-Line γ1 RNA: Structural Characterization of Germ-Line γ1 RNA and Molecular Analysis of the Promoter: A Dissertation, Minzhen Xu

G Protein Interactions with the Substance P Receptor in Rat Submaxillary Gland: a Dissertation, Susan G. Macdonald

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Virus-Lymphocyte Interactions: Virus Expression Is Differentially Modulated by B Cell Activation Signals: A Dissertation, Madelyn R. Schmidt

Publications from 1990

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Role of Recurrent Hydrophobic Residues in Catalyzing Helix Formation by T Cell-Presented Peptides: a Thesis, Shan Lu

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Functional and Structural Characterization of a Human H4 Histone Gene Promoter: a Thesis, Kenneth Lynn Wright

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The Structure, Function, and Regulation of Insulin-like Growth factor II/Mannose 6-phosphate Receptor Forms: a Thesis, Kevin B. Clairmont

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Regulation of β-Adrenergic-Induced Protein Phosphorylation in the Myocardium: A Dissertation, Edward E. George

Fatty Acids Directly Activate K+ Channels in Isolated Gastric and Vascular Smooth Muscle Cells: A Dissertation, Richard W. Ordway

Molecular Biology of Herpesvirus Ateles: A Thesis, David Bruce DeGrand

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Mutually Dependent Elements in the Neurotensin/Neuromedin N Gene Promoter Integrate Multiple Environmental Stimuli in PC12 Cells: a Thesis, Edward H. Kislauskis

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Genetic Analysis of the Saccharomyces Cerevisiae Pheromone Response Pathway: a Thesis, Dmitry B. Blinder

The Control of Maternal Messenger RNA Expression During the Early Development of Xenopus laevis: A Thesis, Laura Lynn McGrew

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The Stimulation of Luteinizing Hormone Secretion from Anterior Pituitary Cells in Culture by Substance P: A Dissertation, Maureen Shamgochian

Regulation of Prostaglandin Biosynthesis by Estrogen and Progesterone in Simian and Ovine Endometrium: a Thesis, Joyce A. Eldering

Identification and Characterization of the Virulence Determinant of the 9.5 Kilobase Plasmid of Yersinia Pestis: a Thesis, Olanrewaju A. Sodeinde

Publications from 1989

Characterization of the Gene and Messages for Vasoactive Intestinal Polypeptide in Rat and Mouse: a Thesis, Edward D. Lamperti

The Role of Guanine Ribonucleotides in Protein Translocation Across the Mammalian Endoplasmic Reticulum: a Thesis, Timothy J. Connolly

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Development of Selective Inhibitors of DNA Polymerase Delta: A Thesis, Robert Vincent Talanian

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Proteolytic Cleavages of Molecules Involved in Antigen Processing and Presentation: A Thesis, Lawrence James Thomas

Genetic Structure of the Bacteriophage P22 PL Operon: A Thesis, Arlene Semerjian

A Molecular Analysis of Selenium Incorporation into Glutathione Peroxidase: Stop Is Not the End: A Thesis, Sunil Chada

Mouse Antibody Response to Group A Streptococcal Carbohydrate: A Thesis, Christopher D. Jarvis

The Membrane Integration of the Hemagglutinin-Neuraminidase Glycoprotein of Newcastle Disease Virus: A Thesis, Cheryl Anne Wilson

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Plasma Membrane Processes in Smooth Muscle: Characterization of Ca2+ Transport and Muscarinic Cholinergic Receptors: A Thesis, Pamela A. Lucchesi

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Structural Determinants of mRNA Turnover in Yeast: a Thesis, David Herrick

Publications from 1988

Interactions between Growth Hormone and the Mechanisms Controlling Arterial Pressure and Renin Secretion in the Rat: A Thesis, Claude Demosthene Simon

Mutations of the Alpha-Subunit of G-Proteins: A Thesis, Chee-Wai Woon

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MYC and E1A Oncogenes Alter the Response of PC12 Cells to Nerve Growth Factor and Block Differentiation: A Thesis, Susan C. Schiavi

Phenotypic and Biochemical Characterization of Cells Expressing a Gas/Gai Chimeric Protein: a Thesis, Charles Nicholas Sidhartha Soparkar

The Cellular Immune Response to Epstein-Barr Virus during Active Infectious Mononucleosis: a Thesis, Blake E. Tomkinson

A Genetic Analysis of RNA Polymerase-Promoter Interactions: A Thesis, Thomas James Gardella

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Characterization of Antigen-Specific Antigen Processing by the Resting B cell: a Thesis, Edmund J. Gosselin

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A Genetic and Structural Analysis of P22 Lysozyme: A Thesis, Dale Rennell

Publications from 1987

Characterization of the Two Non-Allelic Preproinsulin Genes in Mice: a Thesis, Bruce Martin Wentworth

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Cytotoxic Lymphocytes in Viral Hepatitis: a Thesis, Kim W. McIntyre

Cellular mechanism of neutrophil chemotaxis: the role of CA+2, as viewed with the fluorescent dye, FURA-2, in the polarization of human polymorphonuclear leukocytes following stimulation with the chemoattractant, F-Methionyl-Leucyl-Phenylalanine: a thesis, Mary Scanlon

Publications from 1986

An Analysis of the Reversible Phosphorylation of Glycogen Synthase in Rat Heart: a Dissertation, Charles Daniel Wolleben

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Biochemical Studies on the Hemolymph Trypsin Inhibitors of the Tobacco Hornworm Manduca Sexta: A Thesis, Narayanaswamy Ramesh

Publications from 1985

Tn1 Insertions in the 3' Untranslated Region of the ant Operon of Bacteriophage P22 Affect ant Gene Expression and Alter ant mRNA Stability: a Thesis, Linda McMahan

Publications from 1984

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The Role of Natural Killer Cells and Interferon in Virus Infections: A Thesis, Jack F. Bukowski

Expression of the Class II Antigen-Associated Invariant Chain in Leukemic and Virally Transformed Cells, Robert Christopher Spiro