GSBS Dissertations and Theses


Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

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Publications from 1991

Regulation of Polarization and Chemotaxis in Newt Eosinophils: The Role of Calcium: A Dissertation, Rodney Arthur Brundage

Ribosome Binding to the Mammalian Endoplasmic Reticulum: A Thesis, Paula Grosse Collins


Small B Cells as Antigen Presenting Cells in the Induction of Tolerance to Soluble Protein Antigens: A Dissertation, Elizabeth E. Eynon


Glucose Transporter Oligomeric Structure Determines the Mechanism of Glucose Transport: A Dissertation, Daniel N. Hebert

The Human Synapsin I Gene: Linkage Mapping on the X Chromosome: A Dissertation, Cordula U. Kirchgessner

Analysis of B Cell Immediate Early Gene Expression in Response to Contact Dependent T Cell Help and Anti-immunoglobulins: a Thesis, Stephen J. Klaus

G Protein Interactions with the Substance P Receptor in Rat Submaxillary Gland: a Dissertation, Susan G. Macdonald

Signal Transduction by the Epidermal Growth Factor Receptor: a Dissertation, Ingrid C. Northwood


Repair of DNA Containing Small Heterologous Sequences by Escherichia Coli: a Dissertation, Breck Olland Parker


Virus-Lymphocyte Interactions: Virus Expression Is Differentially Modulated by B Cell Activation Signals: A Dissertation, Madelyn R. Schmidt


Transcriptional Control of Human Histone Gene Expression: Delineation and Regulation of Protein/DNA Interactions: A Thesis, Andre John van Wijnen


Regulation of Transcription of Mouse Immunoglobulin Germ-Line γ1 RNA: Structural Characterization of Germ-Line γ1 RNA and Molecular Analysis of the Promoter: A Dissertation, Minzhen Xu

Publications from 1990


Genetic Analysis of the Saccharomyces Cerevisiae Pheromone Response Pathway: a Thesis, Dmitry B. Blinder


The Structure, Function, and Regulation of Insulin-like Growth factor II/Mannose 6-phosphate Receptor Forms: a Thesis, Kevin B. Clairmont

Molecular Biology of Herpesvirus Ateles: A Thesis, David Bruce DeGrand

Regulation of Prostaglandin Biosynthesis by Estrogen and Progesterone in Simian and Ovine Endometrium: a Thesis, Joyce A. Eldering


Regulation of β-Adrenergic-Induced Protein Phosphorylation in the Myocardium: A Dissertation, Edward E. George


Mutually Dependent Elements in the Neurotensin/Neuromedin N Gene Promoter Integrate Multiple Environmental Stimuli in PC12 Cells: a Thesis, Edward H. Kislauskis


Role of Recurrent Hydrophobic Residues in Catalyzing Helix Formation by T Cell-Presented Peptides: a Thesis, Shan Lu

The Control of Maternal Messenger RNA Expression During the Early Development of Xenopus laevis: A Thesis, Laura Lynn McGrew

Fatty Acids Directly Activate K+ Channels in Isolated Gastric and Vascular Smooth Muscle Cells: A Dissertation, Richard W. Ordway


The Stimulation of Luteinizing Hormone Secretion from Anterior Pituitary Cells in Culture by Substance P: A Dissertation, Maureen Shamgochian

Identification and Characterization of the Virulence Determinant of the 9.5 Kilobase Plasmid of Yersinia Pestis: a Thesis, Olanrewaju A. Sodeinde


Functional and Structural Characterization of a Human H4 Histone Gene Promoter: a Thesis, Kenneth Lynn Wright

Publications from 1989

A Molecular Analysis of Selenium Incorporation into Glutathione Peroxidase: Stop Is Not the End: A Thesis, Sunil Chada

The Role of Guanine Ribonucleotides in Protein Translocation Across the Mammalian Endoplasmic Reticulum: a Thesis, Timothy J. Connolly


Structural Determinants of mRNA Turnover in Yeast: a Thesis, David Herrick

Mouse Antibody Response to Group A Streptococcal Carbohydrate: A Thesis, Christopher D. Jarvis

Characterization of the Gene and Messages for Vasoactive Intestinal Polypeptide in Rat and Mouse: a Thesis, Edward D. Lamperti


Plasma Membrane Processes in Smooth Muscle: Characterization of Ca2+ Transport and Muscarinic Cholinergic Receptors: A Thesis, Pamela A. Lucchesi

Genetic Structure of the Bacteriophage P22 PL Operon: A Thesis, Arlene Semerjian


Development of Selective Inhibitors of DNA Polymerase Delta: A Thesis, Robert Vincent Talanian


Proteolytic Cleavages of Molecules Involved in Antigen Processing and Presentation: A Thesis, Lawrence James Thomas

The Membrane Integration of the Hemagglutinin-Neuraminidase Glycoprotein of Newcastle Disease Virus: A Thesis, Cheryl Anne Wilson

Publications from 1988

A Genetic Analysis of RNA Polymerase-Promoter Interactions: A Thesis, Thomas James Gardella


Characterization of Antigen-Specific Antigen Processing by the Resting B cell: a Thesis, Edmund J. Gosselin


A Genetic and Structural Analysis of P22 Lysozyme: A Thesis, Dale Rennell


MYC and E1A Oncogenes Alter the Response of PC12 Cells to Nerve Growth Factor and Block Differentiation: A Thesis, Susan C. Schiavi

Interactions between Growth Hormone and the Mechanisms Controlling Arterial Pressure and Renin Secretion in the Rat: A Thesis, Claude Demosthene Simon

Phenotypic and Biochemical Characterization of Cells Expressing a Gas/Gai Chimeric Protein: a Thesis, Charles Nicholas Sidhartha Soparkar

The Cellular Immune Response to Epstein-Barr Virus during Active Infectious Mononucleosis: a Thesis, Blake E. Tomkinson

Mutations of the Alpha-Subunit of G-Proteins: A Thesis, Chee-Wai Woon

Publications from 1987


Cytotoxic Lymphocytes in Viral Hepatitis: a Thesis, Kim W. McIntyre

Cellular mechanism of neutrophil chemotaxis: the role of CA+2, as viewed with the fluorescent dye, FURA-2, in the polarization of human polymorphonuclear leukocytes following stimulation with the chemoattractant, F-Methionyl-Leucyl-Phenylalanine: a thesis, Mary Scanlon

Characterization of the Two Non-Allelic Preproinsulin Genes in Mice: a Thesis, Bruce Martin Wentworth

Publications from 1986


Biochemical Studies on the Hemolymph Trypsin Inhibitors of the Tobacco Hornworm Manduca Sexta: A Thesis, Narayanaswamy Ramesh

An Analysis of the Reversible Phosphorylation of Glycogen Synthase in Rat Heart: a Dissertation, Charles Daniel Wolleben

Publications from 1985

Tn1 Insertions in the 3' Untranslated Region of the ant Operon of Bacteriophage P22 Affect ant Gene Expression and Alter ant mRNA Stability: a Thesis, Linda McMahan

Publications from 1984


The Role of Natural Killer Cells and Interferon in Virus Infections: A Thesis, Jack F. Bukowski

Expression of the Class II Antigen-Associated Invariant Chain in Leukemic and Virally Transformed Cells, Robert Christopher Spiro