GSBS Dissertations and Theses
Since the school's inception in 1979, students in the University of Massachusetts Medical School's Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.
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Publications from 2020
It’s About Time: Monitoring The Circadian Clock From a Cre-Dependent Reporter, Ciearra B. Smith
The Lipid Handling Capacity of Subcutaneous Fat Requires mTORC2 during Development, Wen-Yu Hsiao
Factors Associated with Mortality After Undergoing Thrombectomy for Acute Ischemic Stroke, Hannah Lin
Role of Tissue Microenvironment in Recruiting Macrophages During Apoptosis-induced Proliferation, Neha Diwanji
Frequency of Complications Following Spinal Fusion in Children with Cerebral Palsy, Nili S. Amir
Genetic Identification of Novel Mycobacterium tuberculosis Susceptibility and Survival Mechanisms During Antibiotic Treatment, Michelle M. Bellerose
English Language Proficiency and Complete Tooth Loss in Older Adults in the United States, Andriana M. Foiles Sifuentes
Characterization of Nucleolus-Associated Domains in Mouse Embryonic Stem Cells, Aizhan Bizhanova
Rit2-Dependent Dopamine Transporter Endocytosis: Intrinsic Mechanism and In Vivo Impact, Rita R. Fagan
Association of Race/Ethnicity and Population Density with Disparities in Timeliness of Rectal Cancer Therapy, Susanna S. Hill
School Nurse Perspectives on the Barriers and Facilitators to School-Supervised Asthma Therapy, Shushmita Hoque
Evaluation of a Tiered Opioid Prescribing Guideline for Inpatient Colorectal Operations, David C. Meyer
Identification and characterization of novel non-coding regulators of innate immune responses in human cells, Shiuli Agarwal
Structural Mechanism of Substrate Specificity In Human Cytidine Deaminase Family APOBEC3s, Shurong Hou
Perceived Efficacy in Patient-Physician Interactions among Older Adults with Atrial Fibrillation, Abraham Lin
Molecular Mechanisms of Resistance and Structure-Based Drug Design in Homodimeric Viral Proteases, Gordon J. Lockbaum
Role of Cis-regulatory Elements in Transcriptional Regulation: From Evolution to 4D Interactions, Pranitha Vangala
A Mixed Methods Study of Local Policy, Systems, and Environmental Approaches Supportive of Healthy Eating and Physical Activity, Meera Sreedhara
The Role of BMP Signaling in the Melanocyte Lineage and as a Therapeutic Target in Melanoma, Alec K. Gramann
Cell Cycle Associated Gene Expression Predicts Function in Mycobacteria, Aditya C. Bandekar
Cytosolic DNA sensing in autoimmune and autoinflammatory diseases, Mona Motwani
Reversing Cancer Cell Fate: Driving Therapeutic Differentiation of Hepatoblastoma to Functional Hepatocyte-Like Cells, Jordan L. Smith
The Role of Type I Interferon in Vitiligo Pathogenesis and Melanoma Immunotherapy, Rebecca L. Riding
Natural Polymorphism of Mycobacterium tuberculosis and CD8 T Cell Immunity, Rujapak Sutiwisesak
Deconstructing bioluminescence: from molecular detail to in vivo imaging., Spencer T. Adams Jr.
Understanding the Production and Stability of Mouse PIWI-Interacting RNAs, Cansu Colpan
Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved AS-NMD pathways, Carrie A. Kovalak
Publications from 2019
TREX Function in piRNA Biogenesis and Transposon Silencing, Gen Zhang
Chromatin Dynamics Regulate Transcriptional Homeostasis, Salih Topal
The Role of S-phase Speed During an Erythroid Transcriptional Switch, Yung Hwang
Modulating MCM Levels Causes Differential Loading at Origins of Replication and Changes Replication Timing, Livio Dukaj
Robustness Mechanisms of Temporal Cell-Fate Progression in C. Elegans, Orkan Ilbay
The Genetics of Functional Axon Regeneration Using C. Elegans, Micah Y. Belew
Compact Cas9s and Their Natural Inhibitors for Genome Editing, Alireza Edraki
The Plasticity and Variation in Gene Expression during Development in C. elegans, Io Long Chan
The Mechanism and Regulation of Bacteriophage DNA Packaging Motors, Janelle A. Hayes
Exploring the Complex Folding Free Energy Landscapes of a Series of β-rich Proteins, Noah R. Cohen
Optimizing CRISPR/Cas9 for Gene Silencing of SOD1 in Mouse Models of ALS, Zachary C. Kennedy
The TALE Factors and Nuclear Factor Y Cooperate to Drive Transcription at Zygotic Genome Activation, William J. Stanney III
Intron and Small RNA Localization in Mammalian Neurons, Harleen Saini
Investigation of a Misfolded, Destabilized Profilin-1 Species as a Toxic Molecule in ALS Pathogenesis, Eric J. Schmidt
Adaptations of Adipose Tissue Expandability in Gestation are Associated with Maternal Glucose Metabolism, Raziel Rojas-Rodriguez
Utilizing Humanized Mice to Study Human Specific Innate Immune Responses in Immuno-Oncology, Ken-Edwin Aryee
Identification of Essential Genes in Hepatocellular Carcinomas using CRISPR Screening, Ankur Sheel
Chromatin Interaction Dynamics Revealed by Liquid Chromatin Hi-C, Houda Belaghzal
Modeling Down Syndrome Neurodevelopment with Dosage Compensation, Jan T. Czerminski
Elucidating the structural mechanisms of capsid stability and assembly using a hyperthermophilic bacteriophage, Nicholas P. Stone
Mechanistic Basis for Control of Early Embryonic Development by a 5’ tRNA Fragment, Xin Y. Bing
Changing trends in the landscape of patients hospitalized with acute myocardial infarction (2001 to 2011): The Worcester Heart Attack Study, Regino Mercado-Lubo
Novel Insight into the Autophagy-Independent Functions of Beclin 1 in Tumor Growth, Asia N. Matthew-Onabanjo
Conserved Features of the T Cell Receptor Repertoire Contribute to the Persistence of EBV-Specific CD8 T Cells, Larisa Kamga
Anticoagulant Use, Safety and Effectiveness for Ischemic Stroke Prevention in Nursing Home Residents with Atrial Fibrillation, Matthew Alcusky
Using Healthcare Data to Inform Health Policy: Quantifying Cardiovascular Disease Risk and Assessing 30-Day Readmission Measures, Hassan Fouayzi
The Role of Mesointerpeduncular Circuitry in Anxiety, Steven R. Degroot
A CNS-Active siRNA Chemical Scaffold for the Treatment of Neurodegenerative Diseases, Julia F. Alterman
Healthcare Disparities and Noncompliance in Children and Young Adults with Crohn’s Disease, Robert McLoughlin
Improved Survival after Administration of Neoadjuvant Chemotherapy in Patients with Clinical Stage I/II Pancreatic Ductal Adenocarcinoma, Ryan J. Hendrix
The non-classical MHC-II molecule DO regulates diversity of the immunopeptidome and selection of the CD4 regulatory T cell lineage, Mollie M. Jurewicz
Caenorhabditis elegans as a Model for Host-Microbe-Drug Interactions, Aurian P. Garcia Gonzalez
Comprehensive Computational Assessment And Evaluation of Epstein Barr virus (EBV) Variations, miRNAs, And EBERs in eBL, AML And Across Cancers, Mercedeh J. Movassagh
Akt Regulation of Mdm2-p53 Signaling in Cellular Stress Responses and Tumorigenesis, Loretah Chibaya
The Convergence of VEGF-Neuropilin and YAP/TAZ Signaling Promotes Stem-Like Traits and DNA Repair in Breast Cancer, Ameer L. Elaimy
Elucidating the Roles of Novel Genes in MHC-I Presentation, Barry Kriegsman
Trends, Predictors, and Consequences of Child Undernutrition in India, Apurv Soni
TCR Signal Strength Controls Dynamic NFAT Activation Threshold and Graded IRF4 Expression in CD8+ T Cells, James M. Conley
The Role of Interferon Gamma in Melanocyte Clearance During Vitiligo, James P. Strassner
Histone Deacetylase 1 and 2 are Essential for Early Cardiac Development, Zachary J. Milstone
Neural Bursting Activity Mediates Subtype-Specific Neural Regeneration by an L-type Calcium Channel, Kendra Takle Ruppell
Vision Beyond Optics: Standardization, Evaluation and Innovation for Fluorescence Microscopy in Life Sciences, Maximiliaan Huisman
Physiological and Psychological Stressors Associated with Glucose Metabolism in the Boston Puerto Rican Health Study, Andrea A. Lopez-Cepero
Are We Optimizing the Use of Dual Antiplatelet Therapy in Patients Hospitalized with Acute Myocardial Infarction?, Essa H. Hariri
Gene Therapy for Amyotrophic Lateral Sclerosis: An AAV Mediated RNAi Approach for Autosomal Dominant C9ORF72 Associated ALS, Gabriela Toro
Religiosity and Patient Activation and Health Outcomes among Hospital Survivors of an Acute Coronary Syndrome, Hawa Ozien Abu
Understanding the Role of Prdm12b in Zebrafish Development, Ozge Yildiz
Towards Understanding the Molecular Basis of Human Endoderm Development Using CRISPR-Effector and Single-Cell Technologies, Ryan M. Genga
Understanding the Experience and Evaluating the Occurrence of Depression in a Sample of Pregnant Veterans, Aimee R. Kroll-Desrosiers
Factors Associated With Weight Management Counseling During Primary Care Clerkships, Karen M. Ashe
Publications from 2018
Understanding regulatory factors in the skin during vitiligo, Kingsley I. Essien
Identification of Deubiquitinating Enzymes that Control the Cell Cycle in Saccharomyces cerevisiae, Claudine E. Mapa
Investigating the Contribution of Disordered Domains to the Biological Activity of RNA-binding Proteins, Davide Tavella
The Relationship Between Inhibition, Conformation, and Catalysis of the Aminopeptidase ERAP1, Zachary Maben
Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells, Benjamin D. Landry
Transcriptional Regulation of Effector and Memory Responses during Acute and Chronic Lymphocytic Choriomeningitis Virus (LCMV) Infection, Elizabeth A. Olesin
The Tec kinase ITK is required for homeostasis and anti-viral immune protection in the intestine, Hyoung-Soo Cho
Histone Deacetylase 3 (HDAC3) Regulates Lymphatic Vascular Development, Harish P. Palleti Janardhan
Fluorescent Visualization of Cellular Proton Fluxes, Lejie Zhang
Chemically Modified Oligonucleotides Silence Mutant SPTLC1 in an in vitro Model of HSAN1, Havisha Bindu Karnam
FUS and Excitotoxicity Cross Paths in ALS: New Insights into Cellular Stress and Disease, Maeve Tischbein
Predictors of Patient Activation at ACS Hospital Discharge and Health Care Utilization in the Subsequent Year, Rebecca L. Kinney
Integrated Analysis of miRNA/mRNA Expression in the Neurocircuitry Underlying Nicotine Dependence, Alison P. Casserly
Understanding Nuage-mitochondrial Coupling in Drosophila piRNA Biogenesis, Tianfang Ge
SERINC5: Its Sensitivity to Nef and Restriction of HIV-1, Weiwei Dai
RIPPLiT and ChimeraTie: High throughput tools for understanding higher order RNP structures, Mihir Metkar
Innate Detection of HIV-1 in Myeloid Dendritic Cells, Sean Matthew McCauley
Inebriated Immunity: Alcohol Affects Innate Immune Signaling in the Gut-Liver-Brain Axis, Patrick P. Lowe
PIE-1, SUMOylation, and Epigenetic Regulation of Germline Specification in Caenorhabditis elegans, Heesun Kim
Studies in Antigen Presentation and Antigen Recognition at Different Interfaces of the Adaptive Immune System, Maria P. Negroni
The Role of Eukaryotic ABC-Transporters in Eliciting Neutrophil infiltration during Streptococcus pneumoniae infection, Andrew Zukauskas
Investigating the Gene Regulatory Network Underlying Caudal Hindbrain Specification in Embryonic Zebrafish, Priyanjali Ghosh
National Trends in Elective Ileal Pouch-Anal Anastomosis for Ulcerative Colitis, Chau Maggie Hoang
Adaptive Evolution of piRNA pathway in Drosophila, Swapnil S. Parhad
Engineered Exosomes for Delivery of Therapeutic siRNAs to Neurons, Reka A. Haraszti
An Examination of MHC, Peptide, and TCR Interactions, Peter Trenh
Follow Your Heart: Evaluating Cardiac Function to Predict Outcomes Among ICU Patients with Traumatic Brain Injury, Patric Gibbons
Innate Immune Signaling Drives Pathogenic Events Leading to Autoimmune Diabetes, Natasha Qaisar
Maelstrom Represses Canonical RNA Polymerase II Transcription in Drosophila Dual-Strand piRNA Clusters, Timothy H. Chang
Targeting Drug Resistance In HCV NS3/4A Protease: Mechanisms And Inhibitor Design Strategies, Ashley N. Matthew
Evaluating Multi-Level Factors Influencing Adolescent Sugar Sweetened Beverage Consumption, Christina F. Griecci
Opioid Use and Safety in United States Nursing Homes, Jacob N. Hunnicutt
A suite of computational tools to interrogate sequence data with local haplotype analysis within complex Plasmodium infections and other microbial mixtures, Nicholas J. Hathaway
Role of TRIP6 and Angiomotins in the Regulation of the Hippo Signaling Pathway, Shubham Dutta
Antigen Specific CD4+ and CD8+ T Cell Recognition During Mycobacterium Tuberculosis Infection, Jason D. Yang
Clostridium difficile Colonization and Infection in the Elderly and Associations with the Aging Intestinal Microbiome, John P. Haran
The cJUN NH2-terminal kinase pathway in mammary gland biology and carcinogenesis, Nomeda A. Girnius
Molecular Mechanisms Underlying Synaptic Connectivity in C. elegans, Alison M. Philbrook
Identification of Novel Genetic Variations for Amyotrophic Lateral Sclerosis (ALS), Guang Xu
Understanding Human Erythrocyte Glucose Transporter (GLUT1) Mediated Glucose Transport Phenomena Through Structural Analysis, Kenneth P. Lloyd
The Role of NFκB Factor Relish in Developmentally Programmed Cell Death, Anubhab Nandy
Mechanisms Regulating the Dopamine Transporter and Their Impact on Behavior, Carolyn G. Sweeney
Watching Sugar Transport in Real Time in Single Cells and Cell Populations, Andrew H. Simon
RUNX1 Is an Oncogenic Transcription Factor that Regulates MYB and MYC Enhancer Activity in T-ALL, AHyun Choi
Investigating the Structural Basis for Human Disease: APOBEC3A and Profilin, Tania V. Silvas
Role of JIP1-JNK Signaling in Beta-Cell Function and Autophagy, Seda Barutcu
The Role of RIPK1 Kinase Activity in Regulating Inflammation and Necroptotic Death, Matija Zelic
Antiviral Immune Responses to Invertebrate Iridescent Virus 6 in Drosophila, Cara C. West
Publications from 2017
Single Molecule Approaches to Mapping DNA Replication Origins, Victor Liu
Transcriptome-Wide Analysis of Roles for Transfer RNA Modifications in Translational Regulation, Hsin-Jung Chou
Small Molecule Modulation of GLUT1-Mediated Glucose Transport, Ogooluwa A. Ojelabi
Adapting the EMPIRIC Approach to Investigate Evolutionary Constraints in Influenza A Virus Surface Proteins, Aneth S. Canale
Identification of Factors Involved in 18S Nonfunctional Ribosomal RNA Decay and a Method for Detecting 8-oxoguanosine by RNA-Seq, Kelly A. Limoncelli
Understanding Multiple Independent Functions of the Tip60 Acetyltransferase in Embryonic Development, Diwash Acharya
Late Antigen Regulates the Differentiation of Cytotoxic CD4 T Cells in Influenza Infection, Allen M. Vong
Astrocytic regulation of seizure-like behavior, Sukhee Cho
Membrane Proteins Take Different Trafficking Pathways to the Primary Cilium, William Joseph Monis
RUNX1 Control of Mammary Epithelial and Breast Cancer Cell Phenotypes, Deli Hong
Analysis, Visualization, and Machine Learning of Epigenomic Data, Michael J. Purcaro
The Transcription Factor Pebbled/RREB1 Regulates Injury-Induced Axon Degeneration, Jonathan E. Farley
Molecular Players in Preserving Excitatory-Inhibitory Balance in the Brain, Wenjie Mao
A Study of Host Factors that Affect Herpes Simplex Virus 1 Pathogenesis: The Role of Cold Sore Susceptibility Gene 1 (CSSG1) in HSV1 Replication, Milan K. Patel
Comparative Oncogenomics Identifies Novel Regulators and Clinical Relevance of Neural Crest Identities in Melanoma, Arvind M. Venkatesan
Development of Chimeric Cas9 Nucleases for Accurate and Flexible Genome Editing, Mehmet F. Bolukbasi
Use of ClinicalTrials.gov Registry in Systematic Reviews and Meta-analyses: A Master's Thesis, Richeek Pradhan
Barriers to Healthcare Access and Patient Outcomes After a Hospitalization for an Acute Coronary Syndrome and Other Acute Conditions, Nathaniel A. K. Erskine
Investigating the Peptide-MHC Specificity of Alloreactive T Cells and Natural T Regulatory Cells Using a Self-peptide Display Library, Brian R. Duke
Exploring the Role of Large Clusters of Branched Aliphatic Residues on the Folding Free Energy Landscape of (βα)8 TIM Barrel Proteins, Kevin T. Halloran
Characterization of Adipose Tissue Inflammation in Alcoholic Liver Disease, Melissa A. Fulham
Identification of KIT as a Suppressor of BRAFV600E-Mutant Melanoma, James V. Neiswender
Dosage Compensation of Trisomy 21 and Its Implications for Hematopoietic Pathogenesis in Down Syndrome, Jen-Chieh Chiang
The Complex Role of Sequence and Structure in the Stability and Function of the TIM Barrel Proteins, Yvonne H. Chan
Innate Immunity As Mediator of Cell Death and Inflammation in Alcoholic Liver Disease, Arvin Iracheta-Vellve
A Systems Approach to Dissecting Immune Gene Regulatory Networks in the Modulation of Brain Function, Yang Xu
Regulation of the FGF/ERK Signaling Pathway: Roles in Zebrafish Gametogenesis and Embryogenesis, Jennifer M. Maurer
Defining a Registry of Candidate Regulatory Elements to Interpret Disease Associated Genetic Variation, Jill E. Moore
Evaluation of IL2 and HLA on the Homeostasis and Function of Human CD4 and CD8 T Cells, Philip A. Durost
Ki-67 Regulates Cell Cycle Progression and Heterochromatin Organization, Xiaoming Sun
Investigating Structural and Functional Defects in ALS-causing Profilin 1 Variants, Sivakumar Boopathy
Neuronal circuitry controlling circadian photoreception in Drosophila, Pallavi Lamba
Platelet Transcriptome Heterogeneity: A Role for RNA Uptake in Vascular Health and Disease, Lauren R. Clancy
Regulation of Pluripotency and Differentiation by Chromatin Remodeling Factors, Ly-Sha Ee
Pathways Involved in Recognition and Induction of Trained Innate Immunity by Plasmodium falciparum, Jacob E. Schrum
Intergenerational Effects of Nicotine in an Animal Model of Paternal Nicotine Exposure, Markus Parzival Vallaster
Genomic and Transcriptomic Investigation of Endemic Burkitt Lymphoma and Epstein Barr Virus, Yasin Kaymaz
Regulation of Local Translation, Synaptic Plasticity, and Cognitive Function by CNOT7, Rhonda L. McFleder
A Two-Pronged Approach to Preeclampsia: Understanding Gene Expression and Targeting sFlt1 using RNAi, Ami Ashar-Patel
Alterations in mRNA 3′UTR Isoform Abundance Accompany Gene Expression Changes in Huntington's Disease, Lindsay S. Romo
Role of Tim3 in Mediating T Cell Exhaustion During Chronic Mycobacterium Tuberculosis Infection, Miye K. Jacques
Regulation of Alloreactive CD8 T Cell Responses by Costimulation and Inflammation, Sonal Jangalwe
A Mechanistic Investigation of Insulin Receptor Substrate 2 Function in Breast Cancer Progression, Jose R. Mercado-Matos
Generation of Pharyngeal Foregut Endoderm from Pluripotent Stem Cells, Nicola A. Kearns
The Role of Skeletal Survey in Identifying Non-Accidental Trauma in Pediatric Trauma Patients, Jonathan Green
Complement-Related Regulates Autophagy in Neighboring Cells, Lin Lin
Identification and Characterization of Rab39a and Its Role in Crosspresentation, Freidrich M. Cruz
Investigating the Role of PIR1 and CD200R1 in the Innate Immune Response to Viral Pathogens, Christopher R. MacKay
Therapeutic Antibody Against Neisseria gonorrhoeae Lipooligosaccharide, a Phase-variable Virulence Factor, Srinjoy Chakraborti
Inhibiting Axon Degeneration in a Mouse Model of Acute Brain Injury Through Deletion of Sarm1, Nils Henninger
Single-Molecule Studies of Replication Kinetics in Response to DNA Damage, Divya Ramalingam Iyer
Characterization of Severe Malaria in Liberian Children 5 Years Old and Younger, Patricia A. McQuilkin
mRNA Decay Pathways Use Translation Fidelity and Competing Decapping Complexes for Substrate Selection, Alper Celik
Three-dimensional Folding of Eukaryotic Genomes, Tsung-Han S. Hsieh
Recent Trends in Sepsis Mortality, Associations between Initial Source of Sepsis and Hospital Mortality, and Predictors of Sepsis Readmission in Sepsis Survivors, Christine Motzkus
Behavioral and Functional Analysis of a Calcium Channelopathy in Caenorhaditis elegans, Yung-Chi Huang
Axon Death Pathways Converge on Axed to Promote Axon Disassembly, Thomas C. Burdett
Impact of Intra-Articular Injection Use on Patient-Reported Outcomes Among Patients with Knee Osteoarthritis, Shao-Hsien Liu
Patient and Social Determinants of Health Trajectories Following Coronary Events, Lisa Nobel
A Synthetic Genetic System to Investigate Brain Connectivity and Genetically Manipulate Interacting Cells, Ting-Hao Huang
Regulation of the Drosophila Initiator Caspase Dronc through Ubiquitylation, Hatem E. Kamber Kaya
Role of Energy Metabolism in the Thermogenic Gene Program, Minwoo Nam
CAF-1 p150 and Ki-67 Regulate Nuclear Structure Throughout the Human Cell Cycle, Timothy D. Matheson
Publications from 2016
The Effects of Interleukin-10 on Skeletal Muscle Insulin Resistance and Myogenesis, Sezin Dagdeviren
Histone Deacetylase 3 Coordinates Heart Development Through Stage-Specific Roles in Cardiac Progenitor Cells, Sara L. Lewandowski
The Origin of Human White, Brown, and Brite/Beige Adipocytes, So Yun Min
Temporal Organization of Behavioral States through Local Neuromodulation in C. elegans, Navonil Banerjee
The Structural Basis for the Interdependence of Drug Resistance in the HIV-1 Protease, Debra A. Ragland
Sex, Drugs, and Rodent Reward: An Exploration of the Sex-Specific Roles of Nicotinic Acetylcholine Receptors in Ethanol Reward, Melissa Guildford Derner
Identification of Essential Metabolic and Genetic Adaptations to the Quiescent State in Mycobacterium Tuberculosis: A Dissertation, Emily S. C. Rittershaus
Targeting Drug Resistance in Chronic Myeloid Leukemia: A Dissertation, Leyuan Ma
Macrophages Are Regulators of Whole Body Metabolism: A Dissertation, Joseph C. Yawe
Requirement and Function of Hippo Pathway Signaling in the Mammalian Gastrointestinal Tract: A Dissertation, Jennifer L. Cotton
The Role of Late Antigen in CD4 Memory T Cell Formation during Influena [i.e. Influenza] Infection: A Dissertation, Bianca L. Bautista
Identification of Novel Pathways that Promote Anoikis through Genome-wide Screens, Victoria E. Pedanou
Evaluating Acceptability, Feasibility and Efficacy of a Diabetes Care Support Program Facilitated by Cellular-Enabled Glucose Meters: A Dissertation, Daniel J. Amante
Mechanisms of Synaptic Development and Premature Aging in Drosophila: A Dissertation, Yihang Li
Overcoming Toxicity from Transgene Overexpression Through Vector Design in AAV Gene Therapy for GM2 Gangliosidoses, Diane L. Golebiowski
Viral Proteases as Drug Targets and the Mechanisms of Drug Resistance: A Dissertation, Kuan-Hung Lin
Tissue Compartmentalization and Tropism of HIV-1: A Dissertation, Robin L. Brese
Levels of YCG1 Limit Condensin Function during the Cell Cycle: A Dissertation, Tyler W. Doughty
Exploiting DNA Repair and ER Stress Response Pathways to Induce Apoptosis in Glioblastoma Multiforme: A Dissertation, Jessica L. Weatherbee
The Role of MDM2 Phosphorylation in P53 Responses to DNA Damage and Tumor Suppression: A Dissertation, Michael I. Carr
Plague and the Defeat of Mammalian Innate Immunity: Systematic Genetic Analysis of Yersinia pestis Virulence Factors: A Dissertation, Samantha G. Palace
A Walk on the Fine Line Between Reward and Risk: AAV-IFNβ Gene Therapy for Glioblastoma: A Dissertation, Dwijit Guhasarkar
Predictors of Post-injury Mortality in Elderly Patients with Trauma: A Master's Thesis, Charles M. Psoinos
Structural Mechanisms of the Sliding Clamp and Sliding Clamp Loader: Insights into Disease and Function: A Dissertation, Caroline M. Duffy
The Drosophila Homolog of the Intellectual Disability Gene ACSL4 Acts in Glia to Regulate Morphology and Neuronal Activity: A Dissertation, Caitlin M. Quigley
Memory CD8+ T Cell Function during Mycobacterium Tuberculosis Infection: A Dissertation, Stephen M. Carpenter
A Role for TNMD in Adipocyte Differentiation and Adipose Tissue Function: A Dissertation, Ozlem Senol-Cosar
The SMURF2-YY1-C-MYC Axis in the Germinal Center Reaction and Diffuse Large B Cell Lymphoma: A Dissertation, Sally E. Trabucco
Viruses Implicated in the Initiation of Type 1 Diabetes Affect β Cell Function and Antiviral Innate Immune Responses: A Dissertation, Glen R. Gallagher
Mechanisms Regulating Early Mesendodermal Differentiation of Human Embryonic Stem Cells: A Dissertation, Jennifer J. VanOudenhove
Activation and Inhibition of Multiple Inflammasome Pathways by the Yersinia Pestis Type Three Secretion System: A Dissertation, Dmitry Ratner
Barriers and Facilitators to Deaf Trauma Survivors’ Help-Seeking Behavior: Lessons for Behavioral Clinical Trials Research: A Master’s Thesis, Melissa L. Anderson
Characterizing the Disorder in Tristetraprolin and its Contribution to Post-Transcriptional Gene Regulation: A Dissertation, Laura M. Deveau
Activation of mTORC1 Improves Cone Cell Metabolism and Extends Vision in Retinitis Pigmentosa Mice: A Dissertation, Aditya Venkatesh
XIST and CoT-1 Repeat RNAs are Integral Components of a Complex Nuclear Scaffold Required to Maintain SAF-A and Modify Chromosome Architecture: A Dissertation, Heather J. Kolpa
The Mechanistic Role and Therapeutic Potential of microRNA-122 in Alcoholic Liver Disease: A Dissertation, Abhishek Satishchandran
Understanding Drug Resistance and Antibody Neutralization Escape in Antivirals: A Dissertation, Kristina L. Prachanronarong
Frailty and Outcomes in Liver Transplantation: A Dissertation, Natasha H. Dolgin
Contraceptive Utilization and Downstream Feto-Maternal Outcomes for Women with Substance Use Disorders: A Dissertation, Gillian J. Griffith
The Impact of mTORC2 Signaling on the Initiation and Progression of KRAS-Driven Pancreatic Neoplasias: A Dissertation, David R. Driscoll
A Novel SMC-Like Protein Modulates C. Elegans Condensin Functions: A Dissertation, Lucy F. Chao
A Role for the Lipid Droplet Protein HIG2 in Promoting Lipid Deposition in Liver and Adipose Tissue: A Dissertation, Marina T. DiStefano
Conceptualizing, Understanding, and Assessing Research Literacy in a Diverse Population: A Dissertation, Lauren R. Powell
Molecular Mechanisms of Assembly and Long-term Maintenance of Neuronal Architecture: A Dissertation, Cassandra R. Blanchette
Synapse Development: Ribonucleoprotein Transport from the Nucleus to the Synapse: A Dissertation, Vahbiz Jokhi
Cytosolic and Endosomal DNA-Sensing Pathways Differentially Regulate Inflammatory Arthritis, Autoantibody Production, and Bone Remodeling: A Dissertation, Rebecca A. Baum
Identification and Characterization of MicroRNA Modulators in Caenorhabditis Elegans: A Dissertation, Zhiji Ren
Eosinophils as Drivers of the IL-23/IL-17 Axis: Implications for Acute Aspergillosis and Allergic Asthma: A Dissertation, Evelyn V. Santos Guerra
Characterization of Higher-order Chromatin Structure in Bone Differentiation and Breast Cancer: A Dissertation, Ahmet Rasim Barutcu
Investigating the Architecture and Vesicle Tethering Function of the Yeast Exocyst Complex: A Dissertation, Margaret R. Heider
Developing an Adeno-Associated Viral Vector (AAV) Toolbox for CNS Gene Therapy: A Dissertation, Sourav Roy Choudhury
Single Molecule Visualization of the DEAH-Box ARPase Prp22 Interacting with the Spliceosome: A Dissertation, Eric G. Anderson
Function of the β4 Integrin in Cancer Stem Cells and Tumor Formation in Breast Cancer: A Masters Thesis, Huayan Sun
Publications from 2015
The Exocyst Subunit Sec6 Interacts with Assembled Exocytic Snare Complexes: A Dissertation, Michelle L. Dubuke
Systematic Dissection of Roles for Chromatin Regulators in Dynamics of Transcriptional Response to Stress in Yeast: A Dissertation, Hsiuyi V. Chen
Hepatitis C Virus: Structural Insights into Protease Inhibitor Efficacy and Drug Resistance: A Dissertation, Djade I. Soumana
Small RNA Regulation of the Innate Immune Response: A Role for Dicer in the Control of Viral Production and Sensing of Nucleic Acids: A Dissertation, Ryan J. Nistler
Single-Molecule Imaging Reveals that Argonaute Re-Shapes the Properties of its Nucleic Acid Guides: A Dissertation, William E. Salomon
Gender Differences in Choice of Procedure and Case Fatality Rate for Elderly Patients with Acute Cholecystitis: A Masters Thesis, Courtney E. Collins
Diet Quality and Evening Snacking in Relation to Sleep Duration and Quality among Women with Young Children: A Dissertation, Rui Sherry Xiao
RNA Exosome & Chromatin: The Yin & Yang of Transcription: A Dissertation, Mayuri Rege
The Epithelial Transmembrane Protein PERP Is Required for Inflammatory Responses to S. typhimurium Infection: A Dissertation, Kelly N. Hallstrom
Age-related Changes in the Neuronal Architecture of Caenorhabditis Elegans: A Dissertation, Anagha Khandekar
Optimizing RNA Library Preparation to Redefine the Translational Status of 80S Monosomes: A Dissertation, Erin E. Heyer
Insights into Melanocyte Regeneration and Melanoma Initiation Using the Zebrafish Model System: A Dissertation, Sharanya Iyengar
The Role of VTA Gabaergic Nicotinic Acetylcholine Receptors Containing the α4 Subunit in Nicotine Dependence: A Dissertation, Jennifer Ngolab
Regulation of Metabolism by Hepatic OXPHOS: A Dissertation, Thomas E. Akie
Unveiling Molecular Mechanisms of piRNA Pathway from Small Signals in Big Data: A Dissertation, Wei Wang
Structural Variation Discovery and Genotyping from Whole Genome Sequencing: Methodology and Applications: A Dissertation, Jiali Zhuang
ATP-Dependent Heterochromatin Remodeling: A Dissertation, Benjamin J. Manning
Pushing The Boundaries of Bioluminescence Using Synthetic Luciferins: A Dissertation, David M. Mofford
The Shape of Silence: The Solution-State Conformation of Sir Heterochromatin: A Dissertation, Sarah G. Swygert
Investigating the Effects of Mutant FUS on Stress Response in Amyotrophic Lateral Sclerosis: A Thesis, Laura J. Kaushansky
Function and Regulation of the Tip60-p400 Complex in Embryonic Stem Cells: A Dissertation, Poshen B. Chen
The Influence of the Insulin-Like Gene Family and Diet-Drug Interactions on Caenorhabditis elegans Physiology: A Dissertation, Ashlyn D. Ritter
Exploring New Strategies to Overcome Resistance in Glioblastoma Multiforme: A Dissertation, Yulian P. Ellis
A Gene-Centered Method For Mapping 3’UTR-RBP Interactions: A Dissertation, Alex M. Tamburino
MicroRNAs Protect the Robustness of Distal Tip Cell Migrations from Temperature Changes in Caenorhabditis elegans: A Dissertation, Samantha L. Burke
Attention Deficit/Hyperactivity Disorder, Screen Time, Physical Activity, and Diet Quality: A Dissertation, Carol Curtin
The Role of Signal 3 Cytokine Timing in CD8 T Cell Activation: A Dissertation, Stina L. Urban
Jun Kinases in Hematopoiesis, and Vascular Development and Function: A Dissertation, Kasmir Ramo
The Role of Medial Habenula-Interpeduncular Nucleus Pathway in Anxiety: A Dissertation, Xueyan Pang
Cell Size Control in the Fission Yeast Schizosaccharomyces pombe: A Dissertation, Daniel L. Keifenheim
Identifying, Targeting, and Exploiting a Common Misfolded, Toxic Conformation of SOD1 in ALS: A Dissertation, Melissa S. Rotunno
Death is Not the End: The Role of Reactive Oxygen Species in Driving Apoptosis-induced Proliferation, Caitlin E. Fogarty
TAK1-Mediated Post-Translational Modifications Modulate Immune Response: A Dissertation, Li Chen
Sentinel Lymph Node Biopsy in Elderly Patients with Intermediate Thickness Melanoma: A Masters Thesis, Kate H. Dinh
Molecular Pathways Mediating Glial Responses during Wallerian Degeneration: A Dissertation, Tsai-Yi Lu
Cathosis: Cathepsins in Particle-induced Inflammatory Cell Death: A Dissertation, Gregory M. Orlowski
Language Proficiency, Citizenship, and Food Insecurity among Predominantly Immigrant Caribbean Latinos in Massachusetts: A Masters Thesis, Tariana V. Little
Role of Protein Kinase Map4k4 in Energy Metabolism: A Dissertation, Laura V. Danai
Causal Inference Methods for Assessing Neurodevelopment in Children Following Prenatal Exposure to Triptan Medications: A Dissertation, Mollie E. Wood
Latent Variable Approaches for Understanding Heterogeneity in Depression: A Dissertation, Christine M. Ulbricht
Systematic Analysis of Duplications and Deletions in the Malaria Parasite P. falciparum: A Dissertation, Derrick K. DeConti
Rapid Access to Perinatal Psychiatric Care in Depression (RAPPID): A Master’s Thesis, Nancy Byatt
Subtle Controllers: MicroRNAs Drive Pancreatic Tumorigenesis and Progression: A Dissertation, Brian J. Quattrochi
Use of Opioids for Pain Management in Nursing Homes: A Dissertation, Camilla B. Pimentel
Role and Regulation of Autophagy During Developmental Cell Death in Drosophila Melanogaster: A Dissertation, Kirsten M. Tracy
Genes Required for Wallerian Degeneration Also Govern Dendrite Degeneration: A Dissertation, Timothy M. Rooney
A Tale of Two Projects: Basis for Centrosome Amplification after DNA Damage and Practical Assessment of Photodamage in Live-Cell Imaging: A Dissertation, Stephen Douthwright
Flipping Biological Switches: Solving for Optimal Control: A Dissertation, Joshua TsuKang Chang
Sensing of Endogenous Nucleic Acids by the Innate Immune System during Viral Infection: A Dissertation, Stefan A. Schattgen
Predicting Other Cause Mortality Risk for Older Men with Localized Prostate Cancer: A Dissertation, Daniel M. Frendl
Paternal Effects on Metabolism in Mammals: A Dissertation, Jeremy M. Shea
A More Accessible Drosophila Genome to Study Fly CNS Development: A Dissertation, Hui-Min Chen
MicroRNA Regulation of Autophagy during Programmed Cell Death: A Dissertation, Charles J. Nelson
Function and Regulation of the α6 Integrins in Mammary Epithelial Biology and Breast Cancer: A Dissertation, Cheng Chang
Endothelial Driven Inflammation in Metabolic Disease: A Dissertation, Anouch Matevossian
Calcium Dependent Regulatory Mechanism in Wolfram Syndrome: A Dissertation, Simin Lu
Advancements in the Synthesis and Application of Near-Infrared Imaging Reagents: A Dissertation, Steven M. Pauff
Autophagy-Independent Role for Beclin 1 in the Regulation of Growth Factor Receptor Signaling: A Dissertation, Rasika Rohatgi
Astrocyte-Neuron Interactions Regulate Nervous System Assembly and Function: A Dissertation, Allie Muthukumar
IRF4 Does the Balancing Act: A Dissertation, Ribhu Nayar
Characterization of Envelope-Specific Antibody Response Elicited by HIV-1 Vaccines: A Dissertation, Yuxin Chen
Publications from 2014
MIRAGE DNA Transposon Silencing by C. elegans Condensin II Subunit HCP-6: A Masters Thesis, Anna Malinkevich
Chromatin Regulators and DNA Repair: A Dissertation, Gwendolyn M. Bennett
Higher-Order Unfolding of Peri/Centric Satellite Heterochromatin is an Early and Consistent Event in Cell Senescence: A Dissertation, Eric C. Swanson
The Recombination Enhancer Modulates the Conformation of Chr. III in Budding Yeast: A Dissertation, Jon-Matthew Belton
Characterization of Innate Immune Pathways in DNA Vaccine-Induced, Antigen-Specific Immune Responses: A Dissertation, John J. Suschak III
rAAV-Mediated Gene Transfer For Study of Pathological Mechanisms and Therapeutic Intervention in Canavan's Disease: A Dissertation, Seemin Seher Ahmed
GLI-IKBKE Requirement In KRAS-Induced Pancreatic Tumorigenesis: A Dissertation, Mihir S. Rajurkar
Amphiphilic Degradable Polymer/Hydroxyapatite Composites as Smart Bone Tissue Engineering Scaffolds: A Dissertation, Artem B. Kutikov
The Three-Dimensional Structure of the Cystic Fibrosis Locus: A Dissertation, Emily M. Smith
Dissecting cis and trans Determinants of Nucleosome Positioning: A Dissertation, Amanda L. Hughes
Oncogene Function in Pre-Leukemia Stage of INV(16) Acute Myeloid Leukemia: A Dissertation, Liting Xue
Role of Mycobacterium Tuberculosis-Induced Necrotic Cell Death of Macrophages in the Pathogenesis of Pulmonary Tuberculosis: A Dissertation, Teresa S. Repasy
Neural Orchestration of the C. elegans Escape Response: A Dissertation, Christopher M. Clark
Regulation of CDK1 Activity during the G1/S Transition in S. cerevisiae through Specific Cyclin-Substrate Docking: A Dissertation, Samyabrata Bhaduri
Small RNAs and Argonautes Provide a Paternal Epigenetic Memory of Germline Gene Expression to Promote Thermotolerant Male Fertility: A Dissertation, Colin C. Conine
Psychometric Evaluation of Joint-Specific Patient-Reported Outcome Measures Before and After Total Knee Replacement: A Dissertation, Barbara L. Gandek
A Feedback Loop Couples Musashi-1 Activity to Omega-9 Fatty Acid Biosynthesis: A Dissertation, Carina C. Clingman
Role of Hdac3 in Murine Coronary Vessel Development: A Master's Thesis, Kevin M. Smee
Comparative Effectiveness of Lithium and Valproate for Suicide Prevention and Associations With Nonsuicide Mortality: A Dissertation, Eric G. Smith
Mechanistic Analysis of Differential Signal Transduction Mediated by the Insulin Receptor Substrate Proteins IRS-1 and IRS-2: A Dissertation, Justine M. Landis
Approaches and Considerations Towards a Safe and Effective Adeno-Associated Virus Mediated Therapeutic Intervention for GM1-Gangliosidosis: A Dissertation, Cara M. Weismann
Hypertensive Acute Decompensated Heart Failure Presentations: On the Decline? : A Master's Thesis, Chad E. Darling
Impact of COPD on the Mortality and Treatment of Patients Hospitalized with Acute Decompensated Heart Failure (The Worcester Heart Failure Study): A Masters Thesis, Kimberly A. Fisher
Early Folding Biases in the Folding Free-Energy Surface of βα-Repeat Proteins: A Dissertation, Robert P. Nobrega
Evolutionary Approaches to the Study of Small Noncoding Regulatory RNA Pathways: A Dissertation, Alfred T. Simkin
Activity Regulates Neuronal Connectivity and Function in the C. elegans Motor Circuit: A Dissertation, Belinda Barbagallo
The Cellular Consequences of FUS/TLS Depletion: A Loss of Function Model for Amyotrophic Lateral Sclerosis: A Dissertation, Catherine L. Ward
Clinical and Financial Impact of Hospital Readmissions Following Colorectal Resection: Predictors, Outcomes, and Costs: A Thesis, Rachelle N. Damle
Differences in Access to Care and Healthcare Utilization Among Sexual Minorities: A Master's Thesis, Tan Phu Pham
Putting the Pieces Together: Exons and piRNAs: A Dissertation, Christian K. Roy
Outpatient Emergency Department Utilization: Measurement and Prediction: A Dissertation, Lisa M. Lines
POS-1 Regulation of Endo-mesoderm Identity in C. elegans: A Dissertation, Ahmed M. Elewa
EspFU, an Enterohemorrhagic E. Coli Secreted Effector, Hijacks Mammalian Actin Assembly Proteins by Molecular Mimicry and Repetition: A Dissertation, YuShuan (Cindy) Lai
An Integrated Structural Mechanism for Relief of Autoinhibition and Membrane Targeting in Cytohesin Family Guanine Nucleotide Exchange Factors: A Dissertation, Andrew W. Malaby
Characterization of Anti-Fungal Inflammasome Responses and the Role of Caspase-8 in Innate Immune Signaling: A Dissertation, Sandhya Ganesan
Complex Roles of Macrophages in Lipid Metabolism and Metabolic Disease: A Dissertation, Kimberly A. Negrin
Dissecting the Role of Cytosolic Nucleic Acid Sensors in the Type I Interferon Response to Herpes Simplex Virus-1 and other Ligands: A Dissertation, Mikayla R. Thompson
Investigating Tumor Suppressors in the DNA Damage Response: Caretakers of the Genome and Biomarkers to Predict Therapeutic Response: A Dissertation, Shawna S. Guillemette
Depression in Rheumatoid Arthritis and an Estimation of the Bi-directional Association of Depression and Disease Burden: A Dissertation, Alan M. Rathbun
Regulation of Type II Responses in Lung Fibrosis and Systemic Autoimmunity: A Dissertation, Tia Bumpus Brodeur
Studies of HLA-DM in Antigen Presentation and CD4+ T Cell Epitope Selection: A Dissertation, Liusong Yin
Identification of Molecular Determinants that Shift Co- and Post-Translational N-Glycosylation Kinetics in Type I Transmembrane Peptides: A Dissertation, Heidi L. H. Malaby
CD8+ T Cell and NK Responses to a Novel Dengue Epitope: A Possible Role for KIR3DL1 in Dengue Pathogenesis: A Dissertation, Elizabeth Townsley
Role of Astrocytes in Sculpting Neuronal Circuits in the Drosophila CNS: A Dissertation, Ozge E. Tasdemir-Yilmaz
Identification and Characteristics of Factors Regulating Hepatocellular Carcinoma Progression and Metastasis: A Dissertation, Leanne G. Ahronian
ADHD-200 Patient Characterization and Classification using Resting State Networks: A Dissertation, Suzanne M. Czerniak
FUS/TLS in Stress Response - Implications for Amyotrophic Lateral Sclerosis: A Dissertation, Reddy Ranjith Kumar Sama
Cognitive Status and Initiation of Lifestyle Changes Following Acute Coronary Heart Syndrome: A Dissertation, Alexandra M. Hajduk
Analyses of All Possible Point Mutations within a Protein Reveals Relationships between Function and Experimental Fitness: A Dissertation, Benjamin P. Roscoe
Characterization of the Visceral Endoderm Components in Early Post-Implantation Mouse Embryo Development: A Dissertation, Tingting Huang
Molecular Landscape of Induced Reprogramming: A Dissertation, Chao-Shun Yang
Heterologous Immunity and T Cell Stability During Viral Infections: A Dissertation, Jenny Wun-Yue Che
Developing Three New Pathophysiologically Based Measures of Nicotine Dependence: A Dissertation, W. W. Sanouri A. Ursprung
Publications from 2013
A Role for Neuronal Nicotinic Acetylcholine Receptors in Dopamine-Mediated Behaviors and the Hypnotic Response to Anesthetics: A Dissertation, Lindsey G. Soll
Tissue-dependent T Cell Apoptosis and Transcriptional Regulation of Memory CD8+T Cell Differentiation During Viral Infections: A Dissertation, Varun N. Kapoor
piRNA Biogenesis and Transposon Silencing in Drosophila: A Dissertation, Zhao Zhang
hox Gene Regulation and Function During Zebrafish Embryogenesis: A Dissertation, Steven E. Weicksel
A Novel Autophagy Regulatory Mechanism that Functions During Programmed Cell Death: A Dissertation, Tsun-Kai Chang
Disparate Activation of the Inflammasome by Chitin and Chitosan: A Dissertation, Chelsea L. Bueter
Human Cytomegalovirus Reprograms the Expression of Host Micro-RNAs whose Target Networks are Required for Viral Replication: A Dissertation, Alexander N. Lagadinos
HIV-1 and the Nucleolus: A Role for Nucleophosmin/NPM1 in Viral Replication: A Dissertation, Tracy E. Schmidt
A Novel Role of UAP56 in piRNA Mediated Transposon Silencing: A Dissertation, Fan Zhang
The Role of Heterologous Immunity in Viral Co-Infections and Neonatal Immunity: A Dissertation, Laurie L. Kenney
Itk is a Dual Action Regulator of Immunoreceptor Signaling in the Innate and Adaptive Immune System: A Dissertation, John W. Evans III
Structure-based Targeting of Transcriptional Regulatory Complexes Implicated in Human Disease: A Dissertation, Brendan J. Hilbert
Morphogenetic Requirements for Embryo Patterning and the Generation of Stem Cell-derived Mice: A Dissertation, Yeonsoo Yoon
Modulating Influenza and Heparin Binding Viruses’ Pathogenesis with Extrinsic Receptor Decoy Liposomes: A Dissertation, Gabriel L. Hendricks
On Identifying Signatures of Positive Selection in Human Populations: A Dissertation, Jessica L. Crisci
Experimental Illumination of Comprehensive Fitness Landscapes: A Dissertation, Ryan T. Hietpas
A Role for Intraflagellar Transport Proteins in Mitosis: A Dissertation, Alison R. Bright
Investigating Cancer Molecular Genetics using Genome-wide RNA Interference Screens: A Dissertation, Ryan W. Serra
Transcriptional and Translational Mechanisms Controlling Circadian Rhythms in Drosophila: A Dissertation, Jinli Ling
dSarm/Sarm1 Governs a Conserved Axon Death Program: A Dissertation, Jeannette M. Osterloh
Investigation of Multiple Concerted Mechanisms Underlying Stimulus-induced G1 Arrest in Yeast: A Dissertation, Patricia A. Pope
RNA Interference by the Numbers: Explaining Biology Through Enzymology: A Dissertation, Liang Meng Wee
Structure and Dynamics of Viral Substrate Recognition and Drug Resistance: A Dissertation, Aysegul Ozen
Expanding the Known DNA-binding Specificity of Homeodomains for Utility in Customizable Sequence-specific Nucleases: A Dissertation, Stephanie W. Chu
The Study of Two Strategies for Decreasing Mutant Huntingtin: Degradation by Puromycin Sensitive AminoPeptidase and RNA Interference: A Dissertation, Joanna Chaurette
The Effects of Family and Social Engagement on the Screen Time of Youth with Developmental Disabilities: A Dissertation, Charmaine B. Lo
The Role and Regulation of Etv2 in Zebrafish Vascular Development: A Dissertation, John C. Moore
Elucidating the Molecular Mechanism of CYLD-Mediated Necrosis: A Dissertation, David M. Moquin
Layered Reward Signalling Through Octopamine and Dopamine in Drosophila: A Dissertation, Christopher J. Burke
The Notch1-c-Myc Pathway Mediates Leukemia-Initiating Cell Activity in Mouse T-ALL Models: A Dissertation, Jessica M. Tesell
Understanding Neural Networks in Awake Rat by Resting-State Functional MRI: A Dissertation, Zhifeng Liang
Role of Map4k4 in Skeletal Muscle Differentiation: A Dissertation, Mengxi Wang
Adjuvant-Specific Serum Cytokine Profiles in the Context of a DNA Prime-Protein Boost HIV-1 Vaccine: A Dissertation, Rachel Buglione-Corbett
Suppressive Oligodeoxynucleotides Inhibit Cytosolic DNA Sensing Pathways: A Dissertation, John J. Kaminski III
Application of a Naïve Bayes Classifier to Assign Polyadenylation Sites from 3' End Deep Sequencing Data: A Dissertation, Sarah E. Sheppard
Genetic Deficiency of CD40 in Mice Exacerbates Metabolic Manifestations of Diet-induced Obesity: A Dissertation, Chang-An Guo
Nuclear Organization in Breast Cancer: A Dissertation, Jason R. Dobson
Role of Autophagy in Post-Mitotic Midbody Fate and Function: A Dissertation, Tse-Chun Kuo
The Role of Ion Channels in Coordinating Neural Circuit Activity in Caenorhabditis elegans: A Dissertation, Jennifer K. Pirri
Local Macrophage Proliferation in Adipose Tissue Is a Characteristic of Obesity-Associated Inflammation: A Dissertation, Shinya U. Amano
Role of Inflammation in Diet-Induced Obesity: A Dissertation, Sophia Kogan
Runx Expression in Normal and Osteoarthritic Cartilage: Possible Functions of Runx Proteins in Chondrocytes: A Dissertation, Kimberly T. LeBlanc
The Role of Inducible T Cell Kinase (Itk) in the Development of Innate T Cells and in the Formation of Protective Memory Responses: A Dissertation, Amanda L. Prince
Role of the Cytoplasmic Polyadenylation Element Binding Proteins in Neuron: A Dissertation, Aparna Oruganty
Regulation of Higher Order Chromatin at GRIN2B and GAD1 Genetic Loci in Human and Mouse Brain: A Dissertation, Rahul Bharadwaj
Modulators of the Acute Inflammatory Response: A Dissertation, Dipti Karmarkar
Identification and Analysis of the Domain Required for Trans-Acceleration Kinetics in the Human Glucose Transporter GLUT1: A Dissertation, Sabrina S. Vollers
Inflammasomes and the Innate Immune Response Against Yersinia Pestis: A Dissertation, Gregory I. Vladimer
Publications from 2012
An Extra-Embryonic Wnt Signaling Event Controls Gastrulation in Mice: A Dissertation, Giovane G. Tortelote
Investigating the Roles of NEDD4.2s and Nef in the Release and Replication of HIV-1: A Dissertation, Eric R. Weiss
Glial Control of Synapse Assembly at the Drosophila Neuromuscular Junction: A Dissertation, Kimberly S. Kerr
Hepatitis C Virus Non-Structural Protein 3/4A: A Tale of Two Domains: A Dissertation, Cihan Aydin
Serotonin-Expressing Cells in the Corpus of the Stomach Originate from Bone Marrow: A Master’s Thesis, Brian T. Johnston
Psychosocial and Behavioral Determinants of Medication Nonadherence Among African Americans with Hypertension: A Dissertation, Yendelela L. Cuffee
A Novel Communication Mechanism Between the Presynapse and Postsynapse Through Exosomes: A Dissertation, Ceren Korkut
Sequence and Target Specificity of the C. elegans Cell Fate Specification Factor POS-1: A Dissertation, Brian M. Farley
Studies on Cellular Host Factors Involved in the HIV-1 Life Cycle: A Dissertation, Anna Kristina Serquiña
The Role of ITK in the Development of Gamma Delta NKT Cells: A Dissertation, Catherine C. Yin
Maintaining the Balance: Coordinating Excitation and Inhibition in a Simple Motor Circuit: A Dissertation, Hilary A. Petrash
Mechanical Activation of Valvular Interstitial Cell Phenotype: A Dissertation, Angela M. Throm Quinlan
Role of Perivascular and Visceral Adipose Tissues in Murine Models of Obesity and Atherosclerosis: A Dissertation, Timothy P. Fitzgibbons
Molecular Studies of T Cell Recognition and Cross-Reactivity: A Dissertation, Zu T. Shen
Gene Expression and Profiling of Human Islet Cell Subtypes: A Master’s Thesis, David M. Blodgett
Protein Ligand Interactions Probed by NMR: A Dissertation, Jennifer M. Laine
MicroRNA Markers of Acetaminophen Toxicity: A Master's Thesis, Jeanine Ward
RNA-Sensing Pattern Recognition Receptors and Their Effects on T-Cell Immune Responses: A Dissertation, Rachel F. Madera
Understanding Small RNA Formation in Drosophila Melanogaster: A Dissertation, Elif Sarinay Cenik
Therapeutic Silencing of Mutant Huntingtin by Targeting Single Nucleotide Polymorphisms: A Dissertation, Edith L. Pfister
Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation, Hugh S. Gannon
Slow-Cycling Cancer Cells: A Dissertation, Nathan F. Moore
Innate Signaling Pathways in the Maintenance of Serological Memory: A Dissertation, Forum M. Raval
Characterization of Drug Resistance in Mycobacterium Tuberculosis via Saturating Mutagenesis of Drug Targets: A Master’s Thesis, Michelle J. Harris
Eaters of the Dead: How Glial Cells Respond to and Engulf Degenerating Axons in the CNS: A Dissertation, Jennifer S. Ziegenfuss
A Role for c-Jun Kinase (JNK) Signaling in Glial Engulfment of Degenerating Axons: A Dissertation, Jennifer M. MacDonald
Transposition Driven Genomic Heterogeneity in the Drosophila Brain: A Dissertation, Paola N. Perrat
Antagonistic Pleiotropy: The Role of Smurf2 in Cancer and Aging: A Dissertation, Charusheila Ramkumar
Mechanisms of KRAS-Mediated Pancreatic Tumor Formation and Progression: A Dissertation, Victoria A. Appleman
Small Molecule Investigation of KCNQ Potassium Channels: A Dissertation, Karen Mruk
Transcriptional Regulation of the Interleukin-8 Promoter by Multiple Dengue Viral Proteins: A Dissertation, Jacob M. Collins
Runx1 C-terminal Domains During Hematopoietic Development and Leukemogenesis: A Dissertation, Christopher R. Dowdy
Chromatin Dynamics in Pluripotency and Differentiation: A Dissertation, Ozlem Yildirim
The Molecular Mechanisms for Maintenance of Cancer Stem Cells in Chronic Myeloid Leukemia: A Dissertation, Haojian Zhang
The Role of Adaptor Protein Complex-3 Delta-Mediated HIV-1 Gag Trafficking in HIV-1 Replication: A Dissertation, Adonia Lee Kim
Inflammation Inhibits Osteoblast-Mediated Bone Formation in Rheumatoid Arthritis and Regulates the Wnt and BMP Signaling Pathways: A Dissertation, Melissa M. Matzelle
HIV-1 R5 Tropism: Determinants, Macrophages, and Dendritic Cells: A Dissertation, Thomas A. Musich
Building the Cell's Antenna: Protein Targeting to the Ciliary Membrane: A Dissertation, John A. Follit
TXNIP is a Mediator of ER Stress-Induced β-Cell Inflammation and Apoptosis: A Dissertation, Christine M. Oslowski
Catalytic Mechanisms in Sec7 and Vps9 Domain Exchange Factors for Arf and Rab GTPases: A Dissertation, Meng-Tse Lee
Targeting the Histone Acetyl-Transferase, RTT109, for Novel Anti-Fungal Drug Development: A Dissertation, Jessica Lopes da Rosa-Spiegler
Genetic Approaches to Study Transcriptional Activation and Tumor Suppression: A Dissertation, Ling Lin
Molecular Mechanisms of Endocytosis: Trafficking and Functional Requirements for the Transferrin Receptor, Small Interfering RNAs and Dopamine Transporter: A Dissertation, Deanna M. Navaroli
Incidence, prognosis, and factors associated with cardiac arrest in patients hospitalized with acute coronary syndromes (the GRACE Registry): A master's thesis, David D. McManus
Getting a Tight Grip on DNA: Optimizing Zinc Fingers for Efficient ZFN-Mediated Gene Editing: A Dissertation, Ankit Gupta
Lack of CFTR in CD3+ Lymphocytes Leads to Aberrant Cytokine Secretion and Hyper-Inflammatory Adaptive Immune Responses: A Master's Thesis, Christian Mueller
Contribution of WFS1 to Pancreatic Beta Cell Survival and Adaptive Alterations in WFS1 Deficiency: A Dissertation, Bryan M. O'Sullivan-Murphy
Origin of White and Brown Adipose Cells From Vascular Endothelium: A Dissertation, Khanh-Van T. Tran
Gene Therapy for Very Long Chain Acyl-coA Dehydrogenase Deficiency Using Adeno-Associated Virus Vectors: A Dissertation, Allison M. Keeler
Analysis of Integrin α6β4 Function in Breast Carcinoma: A Dissertation, Kristin D. Gerson
On the Source of Peptides for Major Histocompatibility Class I Antigen Presentation: A Dissertation, Diego José Farfán Arribas
The Subtype Specific and Cross-Reactive T Cell Responses to Influenza Viruses in Humans: A Dissertation, Jenny Aurielle B. Babon
Localization of Insulin Receptor Substrate-2 in Breast Cancer: A Dissertation, Jennifer L. Clark
The Role of Heterologous Immunity in Mediating Natural Resistance to Infection in Human Subjects: A Dissertation, Levi B. Watkin
Dissecting Somatic Cell Reprogramming by MicroRNAs and Small Molecules: A Dissertation, Zhonghan Li
Characterization of New Factors in the 18S Nonfunctional Ribosomal RNA Decay Pathway in S. cerevisiae: A Dissertation, Christopher N. Merrikh