GSBS Dissertations and Theses
Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.
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Publications from 2018
Role of JIP1-JNK Signaling in Beta-Cell Function and Autophagy, Seda Barutcu
Maelstrom Represses Canonical RNA Polymerase II Transcription in Drosophila Dual-Strand piRNA Clusters, Timothy H. Chang
RUNX1 Is an Oncogenic Transcription Factor that Regulates MYB and MYC Enhancer Activity in T-ALL, AHyun Choi
Role of TRIP6 and Angiomotins in the Regulation of the Hippo Signaling Pathway, Shubham Dutta
Follow Your Heart: Evaluating Cardiac Function to Predict Outcomes Among ICU Patients with Traumatic Brain Injury, Patric Gibbons
The cJUN NH2-terminal kinase pathway in mammary gland biology and carcinogenesis, Nomeda A. Girnius
Evaluating Multi-Level Factors Influencing Adolescent Sugar Sweetened Beverage Consumption, Christina F. Griecci
Clostridium difficile Colonization and Infection in the Elderly and Associations with the Aging Intestinal Microbiome, John P. Haran
Engineered Exosomes for Delivery of Therapeutic siRNAs to Neurons, Reka A. Haraszti
A suite of computational tools to interrogate sequence data with local haplotype analysis within complex Plasmodium infections and other microbial mixtures, Nicholas J. Hathaway
National Trends in Elective Ileal Pouch-Anal Anastomosis for Ulcerative Colitis, Chau Maggie Hoang
Opioid Use and Safety in United States Nursing Homes, Jacob N. Hunnicutt
Understanding Human Erythrocyte Glucose Transporter (GLUT1) Mediated Glucose Transport Phenomena Through Structural Analysis, Kenneth P. Lloyd
Targeting Drug Resistance In HCV NS3/4A Protease: Mechanisms And Inhibitor Design Strategies, Ashley N. Matthew
The Role of NFκB Factor Relish in Developmentally Programmed Cell Death, Anubhab Nandy
Molecular Mechanisms Underlying Synaptic Connectivity in C. elegans, Alison M. Philbrook
Innate Immune Signaling Drives Pathogenic Events Leading to Autoimmune Diabetes, Natasha Qaisar
Investigating the Structural Basis for Human Disease: APOBEC3A and Profilin, Tania V. Silvas
Watching Sugar Transport in Real Time in Single Cells and Cell Populations, Andrew H. Simon
Mechanisms Regulating the Dopamine Transporter and Their Impact on Behavior, Carolyn G. Sweeney
Antiviral Immune Responses to Invertebrate Iridescent Virus 6 in Drosophila, Cara C. West
Identification of Novel Genetic Variations for Amyotrophic Lateral Sclerosis (ALS), Guang Xu
Antigen Specific CD4+ and CD8+ T Cell Recognition During Mycobacterium Tuberculosis Infection, Jason D. Yang
The Role of RIPK1 Kinase Activity in Regulating Inflammation and Necroptotic Death, Matija Zelic
Publications from 2017
Understanding Multiple Independent Functions of the Tip60 Acetyltransferase in Embryonic Development, Diwash Acharya
A Two-Pronged Approach to Preeclampsia: Understanding Gene Expression and Targeting sFlt1 using RNAi, Ami Ashar-Patel
Development of Chimeric Cas9 Nucleases for Accurate and Flexible Genome Editing, Mehmet F. Bolukbasi
Investigating Structural and Functional Defects in ALS-causing Profilin 1 Variants, Sivakumar Boopathy
Axon Death Pathways Converge on Axed to Promote Axon Disassembly, Thomas C. Burdett
Adapting the EMPIRIC Approach to Investigate Evolutionary Constraints in Influenza A Virus Surface Proteins, Aneth S. Canale
mRNA Decay Pathways Use Translation Fidelity and Competing Decapping Complexes for Substrate Selection, Alper Celik
Therapeutic Antibody Against Neisseria gonorrhoeae Lipooligosaccharide, a Phase-variable Virulence Factor, Srinjoy Chakraborti
The Complex Role of Sequence and Structure in the Stability and Function of the TIM Barrel Proteins, Yvonne H. Chan
Dosage Compensation of Trisomy 21 and Its Implications for Hematopoietic Pathogenesis in Down Syndrome, Jen-Chieh Chiang
Astrocytic regulation of seizure-like behavior, Sukhee Cho
Transcriptome-Wide Analysis of Roles for Transfer RNA Modifications in Translational Regulation, Hsin-Jung Chou
Platelet Transcriptome Heterogeneity: A Role for RNA Uptake in Vascular Health and Disease, Lauren R. Clancy
Identification and Characterization of Rab39a and Its Role in Crosspresentation, Freidrich M. Cruz
Investigating the Peptide-MHC Specificity of Alloreactive T Cells and Natural T Regulatory Cells Using a Self-peptide Display Library, Brian R. Duke
Evaluation of IL2 and HLA on the Homeostasis and Function of Human CD4 and CD8 T Cells, Philip A. Durost
Regulation of Pluripotency and Differentiation by Chromatin Remodeling Factors, Ly-Sha Ee
Barriers to Healthcare Access and Patient Outcomes After a Hospitalization for an Acute Coronary Syndrome and Other Acute Conditions, Nathaniel A. K. Erskine
The Transcription Factor Pebbled/RREB1 Regulates Injury-Induced Axon Degeneration, Jonathan E. Farley
Characterization of Adipose Tissue Inflammation in Alcoholic Liver Disease, Melissa A. Fulham
The Role of Skeletal Survey in Identifying Non-Accidental Trauma in Pediatric Trauma Patients, Jonathan Green
Exploring the Role of Large Clusters of Branched Aliphatic Residues on the Folding Free Energy Landscape of (βα)8 TIM Barrel Proteins, Kevin T. Halloran
Inhibiting Axon Degeneration in a Mouse Model of Acute Brain Injury Through Deletion of Sarm1, Nils Henninger
RUNX1 Control of Mammary Epithelial and Breast Cancer Cell Phenotypes, Deli Hong
Three-dimensional Folding of Eukaryotic Genomes, Tsung-Han S. Hsieh
A Synthetic Genetic System to Investigate Brain Connectivity and Genetically Manipulate Interacting Cells, Ting-Hao Huang
Behavioral and Functional Analysis of a Calcium Channelopathy in Caenorhaditis elegans, Yung-Chi Huang
Innate Immunity As Mediator of Cell Death and Inflammation in Alcoholic Liver Disease, Arvin Iracheta-Vellve
Single-Molecule Studies of Replication Kinetics in Response to DNA Damage, Divya Ramalingam Iyer
Role of Tim3 in Mediating T Cell Exhaustion During Chronic Mycobacterium Tuberculosis Infection, Miye K. Jacques
Regulation of Alloreactive CD8 T Cell Responses by Costimulation and Inflammation, Sonal Jangalwe
Regulation of the Drosophila Initiator Caspase Dronc through Ubiquitylation, Hatem E. Kamber Kaya
Genomic and Transcriptomic Investigation of Endemic Burkitt Lymphoma and Epstein Barr Virus, Yasin Kaymaz
Generation of Pharyngeal Foregut Endoderm from Pluripotent Stem Cells, Nicola A. Kearns
Neuronal circuitry controlling circadian photoreception in Drosophila, Pallavi Lamba
Identification of Factors Involved in 18S Nonfunctional Ribosomal RNA Decay and a Method for Detecting 8-oxoguanosine by RNA-Seq, Kelly A. Limoncelli
Complement-Related Regulates Autophagy in Neighboring Cells, Lin Lin
Impact of Intra-Articular Injection Use on Patient-Reported Outcomes Among Patients with Knee Osteoarthritis, Shao-Hsien Liu
Single Molecule Approaches to Mapping DNA Replication Origins, Victor Liu
Investigating the Role of PIR1 and CD200R1 in the Innate Immune Response to Viral Pathogens, Christopher R. MacKay
Molecular Players in Preserving Excitatory-Inhibitory Balance in the Brain, Wenjie Mao
CAF-1 p150 and Ki-67 Regulate Nuclear Structure Throughout the Human Cell Cycle, Timothy D. Matheson
Regulation of the FGF/ERK Signaling Pathway: Roles in Zebrafish Gametogenesis and Embryogenesis, Jennifer M. Maurer
Regulation of Local Translation, Synaptic Plasticity, and Cognitive Function by CNOT7, Rhonda L. McFleder
Characterization of Severe Malaria in Liberian Children 5 Years Old and Younger, Patricia A. McQuilkin
A Mechanistic Investigation of Insulin Receptor Substrate 2 Function in Breast Cancer Progression, Jose R. Mercado-Matos
Membrane Proteins Take Different Trafficking Pathways to the Primary Cilium, William Joseph Monis
Defining a Registry of Candidate Regulatory Elements to Interpret Disease Associated Genetic Variation, Jill E. Moore
Recent Trends in Sepsis Mortality, Associations between Initial Source of Sepsis and Hospital Mortality, and Predictors of Sepsis Readmission in Sepsis Survivors, Christine Motzkus
Role of Energy Metabolism in the Thermogenic Gene Program, Minwoo Nam
Identification of KIT as a Suppressor of BRAFV600E-Mutant Melanoma, James V. Neiswender
Patient and Social Determinants of Health Trajectories Following Coronary Events, Lisa Nobel
Small Molecule Modulation of GLUT1-Mediated Glucose Transport, Ogooluwa A. Ojelabi
A Study of Host Factors that Affect Herpes Simplex Virus 1 Pathogenesis: The Role of Cold Sore Susceptibility Gene 1 (CSSG1) in HSV1 Replication, Milan K. Patel
Use of ClinicalTrials.gov Registry in Systematic Reviews and Meta-analyses: A Master's Thesis, Richeek Pradhan
Analysis, Visualization, and Machine Learning of Epigenomic Data, Michael J. Purcaro
Alterations in mRNA 3′UTR Isoform Abundance Accompany Gene Expression Changes in Huntington's Disease, Lindsay S. Romo
Pathways Involved in Recognition and Induction of Trained Innate Immunity by Plasmodium falciparum, Jacob E. Schrum
Ki-67 Regulates Cell Cycle Progression and Heterochromatin Organization, Xiaoming Sun
Intergenerational Effects of Nicotine in an Animal Model of Paternal Nicotine Exposure, Markus Parzival Vallaster
Comparative Oncogenomics Identifies Novel Regulators and Clinical Relevance of Neural Crest Identities in Melanoma, Arvind M. Venkatesan
Late Antigen Regulates the Differentiation of Cytotoxic CD4 T Cells in Influenza Infection, Allen M. Vong
A Systems Approach to Dissecting Immune Gene Regulatory Networks in the Modulation of Brain Function, Yang Xu
Publications from 2016
Evaluating Acceptability, Feasibility and Efficacy of a Diabetes Care Support Program Facilitated by Cellular-Enabled Glucose Meters: A Dissertation, Daniel J. Amante
Single Molecule Visualization of the DEAH-Box ARPase Prp22 Interacting with the Spliceosome: A Dissertation, Eric G. Anderson
Barriers and Facilitators to Deaf Trauma Survivors’ Help-Seeking Behavior: Lessons for Behavioral Clinical Trials Research: A Master’s Thesis, Melissa L. Anderson
Temporal Organization of Behavioral States through Local Neuromodulation in C. elegans, Navonil Banerjee
Characterization of Higher-order Chromatin Structure in Bone Differentiation and Breast Cancer: A Dissertation, Ahmet Rasim Barutcu
Cytosolic and Endosomal DNA-Sensing Pathways Differentially Regulate Inflammatory Arthritis, Autoantibody Production, and Bone Remodeling: A Dissertation, Rebecca A. Baum
The Role of Late Antigen in CD4 Memory T Cell Formation during Influena [i.e. Influenza] Infection: A Dissertation, Bianca L. Bautista
Molecular Mechanisms of Assembly and Long-term Maintenance of Neuronal Architecture: A Dissertation, Cassandra R. Blanchette
Tissue Compartmentalization and Tropism of HIV-1: A Dissertation, Robin L. Brese
Memory CD8+ T Cell Function during Mycobacterium Tuberculosis Infection: A Dissertation, Stephen M. Carpenter
The Role of MDM2 Phosphorylation in P53 Responses to DNA Damage and Tumor Suppression: A Dissertation, Michael I. Carr
A Novel SMC-Like Protein Modulates C. Elegans Condensin Functions: A Dissertation, Lucy F. Chao
Developing an Adeno-Associated Viral Vector (AAV) Toolbox for CNS Gene Therapy: A Dissertation, Sourav Roy Choudhury
Requirement and Function of Hippo Pathway Signaling in the Mammalian Gastrointestinal Tract: A Dissertation, Jennifer L. Cotton
The Effects of Interleukin-10 on Skeletal Muscle Insulin Resistance and Myogenesis, Sezin Dagdeviren
Sex, Drugs, and Rodent Reward: An Exploration of the Sex-Specific Roles of Nicotinic Acetylcholine Receptors in Ethanol Reward, Melissa Guildford Derner
Characterizing the Disorder in Tristetraprolin and its Contribution to Post-Transcriptional Gene Regulation: A Dissertation, Laura M. Deveau
A Role for the Lipid Droplet Protein HIG2 in Promoting Lipid Deposition in Liver and Adipose Tissue: A Dissertation, Marina T. DiStefano
Frailty and Outcomes in Liver Transplantation: A Dissertation, Natasha H. Dolgin
Levels of YCG1 Limit Condensin Function during the Cell Cycle: A Dissertation, Tyler W. Doughty
The Impact of mTORC2 Signaling on the Initiation and Progression of KRAS-Driven Pancreatic Neoplasias: A Dissertation, David R. Driscoll
Structural Mechanisms of the Sliding Clamp and Sliding Clamp Loader: Insights into Disease and Function: A Dissertation, Caroline M. Duffy
Viruses Implicated in the Initiation of Type 1 Diabetes Affect β Cell Function and Antiviral Innate Immune Responses: A Dissertation, Glen R. Gallagher
Overcoming Toxicity from Transgene Overexpression Through Vector Design in AAV Gene Therapy for GM2 Gangliosidoses, Diane L. Golebiowski
Contraceptive Utilization and Downstream Feto-Maternal Outcomes for Women with Substance Use Disorders: A Dissertation, Gillian J. Griffith
Eosinophils as Drivers of the IL-23/IL-17 Axis: Implications for Acute Aspergillosis and Allergic Asthma: A Dissertation, Evelyn V. Santos Guerra
A Walk on the Fine Line Between Reward and Risk: AAV-IFNβ Gene Therapy for Glioblastoma: A Dissertation, Dwijit Guhasarkar
Investigating the Architecture and Vesicle Tethering Function of the Yeast Exocyst Complex: A Dissertation, Margaret R. Heider
Synapse Development: Ribonucleoprotein Transport from the Nucleus to the Synapse: A Dissertation, Vahbiz Jokhi
XIST and CoT-1 Repeat RNAs are Integral Components of a Complex Nuclear Scaffold Required to Maintain SAF-A and Modify Chromosome Architecture: A Dissertation, Heather J. Kolpa
Histone Deacetylase 3 Coordinates Heart Development Through Stage-Specific Roles in Cardiac Progenitor Cells, Sara L. Lewandowski
Viral Proteases as Drug Targets and the Mechanisms of Drug Resistance: A Dissertation, Kuan-Hung Lin
Mechanisms of Synaptic Development and Premature Aging in Drosophila: A Dissertation, Yihang Li
Targeting Drug Resistance in Chronic Myeloid Leukemia: A Dissertation, Leyuan Ma
The Origin of Human White, Brown, and Brite/Beige Adipocytes, So Yun Min
Plague and the Defeat of Mammalian Innate Immunity: Systematic Genetic Analysis of Yersinia pestis Virulence Factors: A Dissertation, Samantha G. Palace
Identification of Novel Pathways that Promote Anoikis through Genome-wide Screens, Victoria E. Pedanou
Conceptualizing, Understanding, and Assessing Research Literacy in a Diverse Population: A Dissertation, Lauren R. Powell
Understanding Drug Resistance and Antibody Neutralization Escape in Antivirals: A Dissertation, Kristina L. Prachanronarong
Predictors of Post-injury Mortality in Elderly Patients with Trauma: A Master's Thesis, Charles M. Psoinos
The Drosophila Homolog of the Intellectual Disability Gene ACSL4 Acts in Glia to Regulate Morphology and Neuronal Activity: A Dissertation, Caitlin M. Quigley
The Structural Basis for the Interdependence of Drug Resistance in the HIV-1 Protease, Debra A. Ragland
Activation and Inhibition of Multiple Inflammasome Pathways by the Yersinia Pestis Type Three Secretion System: A Dissertation, Dmitry Ratner
Identification and Characterization of MicroRNA Modulators in Caenorhabditis Elegans: A Dissertation, Zhiji Ren
Identification of Essential Metabolic and Genetic Adaptations to the Quiescent State in Mycobacterium Tuberculosis: A Dissertation, Emily S. C. Rittershaus
The Mechanistic Role and Therapeutic Potential of microRNA-122 in Alcoholic Liver Disease: A Dissertation, Abhishek Satishchandran
A Role for TNMD in Adipocyte Differentiation and Adipose Tissue Function: A Dissertation, Ozlem Senol-Cosar
Function of the β4 Integrin in Cancer Stem Cells and Tumor Formation in Breast Cancer: A Masters Thesis, Huayan Sun
The SMURF2-YY1-C-MYC Axis in the Germinal Center Reaction and Diffuse Large B Cell Lymphoma: A Dissertation, Sally E. Trabucco
Mechanisms Regulating Early Mesendodermal Differentiation of Human Embryonic Stem Cells: A Dissertation, Jennifer J. VanOudenhove
Activation of mTORC1 Improves Cone Cell Metabolism and Extends Vision in Retinitis Pigmentosa Mice: A Dissertation, Aditya Venkatesh
Exploiting DNA Repair and ER Stress Response Pathways to Induce Apoptosis in Glioblastoma Multiforme: A Dissertation, Jessica L. Weatherbee
Macrophages Are Regulators of Whole Body Metabolism: A Dissertation, Joseph C. Yawe
Publications from 2015
Regulation of Metabolism by Hepatic OXPHOS: A Dissertation, Thomas E. Akie
MicroRNAs Protect the Robustness of Distal Tip Cell Migrations from Temperature Changes in Caenorhabditis elegans: A Dissertation, Samantha L. Burke
Rapid Access to Perinatal Psychiatric Care in Depression (RAPPID): A Master’s Thesis, Nancy Byatt
Function and Regulation of the α6 Integrins in Mammary Epithelial Biology and Breast Cancer: A Dissertation, Cheng Chang
Flipping Biological Switches: Solving for Optimal Control: A Dissertation, Joshua TsuKang Chang
Systematic Dissection of Roles for Chromatin Regulators in Dynamics of Transcriptional Response to Stress in Yeast: A Dissertation, Hsiuyi V. Chen
A More Accessible Drosophila Genome to Study Fly CNS Development: A Dissertation, Hui-Min Chen
TAK1-Mediated Post-Translational Modifications Modulate Immune Response: A Dissertation, Li Chen
Function and Regulation of the Tip60-p400 Complex in Embryonic Stem Cells: A Dissertation, Poshen B. Chen
Characterization of Envelope-Specific Antibody Response Elicited by HIV-1 Vaccines: A Dissertation, Yuxin Chen
Gender Differences in Choice of Procedure and Case Fatality Rate for Elderly Patients with Acute Cholecystitis: A Masters Thesis, Courtney E. Collins
Attention Deficit/Hyperactivity Disorder, Screen Time, Physical Activity, and Diet Quality: A Dissertation, Carol Curtin
Role of Protein Kinase Map4k4 in Energy Metabolism: A Dissertation, Laura V. Danai
Systematic Analysis of Duplications and Deletions in the Malaria Parasite P. falciparum: A Dissertation, Derrick K. DeConti
Sentinel Lymph Node Biopsy in Elderly Patients with Intermediate Thickness Melanoma: A Masters Thesis, Kate H. Dinh
A Tale of Two Projects: Basis for Centrosome Amplification after DNA Damage and Practical Assessment of Photodamage in Live-Cell Imaging: A Dissertation, Stephen Douthwright
The Exocyst Subunit Sec6 Interacts with Assembled Exocytic Snare Complexes: A Dissertation, Michelle L. Dubuke
Exploring New Strategies to Overcome Resistance in Glioblastoma Multiforme: A Dissertation, Yulian P. Ellis
Death is Not the End: The Role of Reactive Oxygen Species in Driving Apoptosis-induced Proliferation, Caitlin E. Fogarty
Predicting Other Cause Mortality Risk for Older Men with Localized Prostate Cancer: A Dissertation, Daniel M. Frendl
The Epithelial Transmembrane Protein PERP Is Required for Inflammatory Responses to S. typhimurium Infection: A Dissertation, Kelly N. Hallstrom
Optimizing RNA Library Preparation to Redefine the Translational Status of 80S Monosomes: A Dissertation, Erin E. Heyer
Insights into Melanocyte Regeneration and Melanoma Initiation Using the Zebrafish Model System: A Dissertation, Sharanya Iyengar
Investigating the Effects of Mutant FUS on Stress Response in Amyotrophic Lateral Sclerosis: A Thesis, Laura J. Kaushansky
Cell Size Control in the Fission Yeast Schizosaccharomyces pombe: A Dissertation, Daniel L. Keifenheim
Age-related Changes in the Neuronal Architecture of Caenorhabditis Elegans: A Dissertation, Anagha Khandekar
Language Proficiency, Citizenship, and Food Insecurity among Predominantly Immigrant Caribbean Latinos in Massachusetts: A Masters Thesis, Tariana V. Little
Calcium Dependent Regulatory Mechanism in Wolfram Syndrome: A Dissertation, Simin Lu
Molecular Pathways Mediating Glial Responses during Wallerian Degeneration: A Dissertation, Tsai-Yi Lu
ATP-Dependent Heterochromatin Remodeling: A Dissertation, Benjamin J. Manning
Endothelial Driven Inflammation in Metabolic Disease: A Dissertation, Anouch Matevossian
Pushing The Boundaries of Bioluminescence Using Synthetic Luciferins: A Dissertation, David M. Mofford
Astrocyte-Neuron Interactions Regulate Nervous System Assembly and Function: A Dissertation, Allie Muthukumar
IRF4 Does the Balancing Act: A Dissertation, Ribhu Nayar
MicroRNA Regulation of Autophagy during Programmed Cell Death: A Dissertation, Charles J. Nelson
The Role of VTA Gabaergic Nicotinic Acetylcholine Receptors Containing the α4 Subunit in Nicotine Dependence: A Dissertation, Jennifer Ngolab
Small RNA Regulation of the Innate Immune Response: A Role for Dicer in the Control of Viral Production and Sensing of Nucleic Acids: A Dissertation, Ryan J. Nistler
Cathosis: Cathepsins in Particle-induced Inflammatory Cell Death: A Dissertation, Gregory M. Orlowski
The Role of Medial Habenula-Interpeduncular Nucleus Pathway in Anxiety: A Dissertation, Xueyan Pang
Advancements in the Synthesis and Application of Near-Infrared Imaging Reagents: A Dissertation, Steven M. Pauff
Use of Opioids for Pain Management in Nursing Homes: A Dissertation, Camilla B. Pimentel
Subtle Controllers: MicroRNAs Drive Pancreatic Tumorigenesis and Progression: A Dissertation, Brian J. Quattrochi
Jun Kinases in Hematopoiesis, and Vascular Development and Function: A Dissertation, Kasmir Ramo
RNA Exosome & Chromatin: The Yin & Yang of Transcription: A Dissertation, Mayuri Rege
The Influence of the Insulin-Like Gene Family and Diet-Drug Interactions on Caenorhabditis elegans Physiology: A Dissertation, Ashlyn D. Ritter
Autophagy-Independent Role for Beclin 1 in the Regulation of Growth Factor Receptor Signaling: A Dissertation, Rasika Rohatgi
Genes Required for Wallerian Degeneration Also Govern Dendrite Degeneration: A Dissertation, Timothy M. Rooney
Identifying, Targeting, and Exploiting a Common Misfolded, Toxic Conformation of SOD1 in ALS: A Dissertation, Melissa S. Rotunno
Single-Molecule Imaging Reveals that Argonaute Re-Shapes the Properties of its Nucleic Acid Guides: A Dissertation, William E. Salomon
Sensing of Endogenous Nucleic Acids by the Innate Immune System during Viral Infection: A Dissertation, Stefan A. Schattgen
Paternal Effects on Metabolism in Mammals: A Dissertation, Jeremy M. Shea
Hepatitis C Virus: Structural Insights into Protease Inhibitor Efficacy and Drug Resistance: A Dissertation, Djade I. Soumana
The Shape of Silence: The Solution-State Conformation of Sir Heterochromatin: A Dissertation, Sarah G. Swygert
A Gene-Centered Method For Mapping 3’UTR-RBP Interactions: A Dissertation, Alex M. Tamburino
Role and Regulation of Autophagy During Developmental Cell Death in Drosophila Melanogaster: A Dissertation, Kirsten M. Tracy
Latent Variable Approaches for Understanding Heterogeneity in Depression: A Dissertation, Christine M. Ulbricht
The Role of Signal 3 Cytokine Timing in CD8 T Cell Activation: A Dissertation, Stina L. Urban
Unveiling Molecular Mechanisms of piRNA Pathway from Small Signals in Big Data: A Dissertation, Wei Wang
Causal Inference Methods for Assessing Neurodevelopment in Children Following Prenatal Exposure to Triptan Medications: A Dissertation, Mollie E. Wood
Diet Quality and Evening Snacking in Relation to Sleep Duration and Quality among Women with Young Children: A Dissertation, Rui Sherry Xiao
Structural Variation Discovery and Genotyping from Whole Genome Sequencing: Methodology and Applications: A Dissertation, Jiali Zhuang
Publications from 2014
rAAV-Mediated Gene Transfer For Study of Pathological Mechanisms and Therapeutic Intervention in Canavan's Disease: A Dissertation, Seemin Seher Ahmed
Identification and Characteristics of Factors Regulating Hepatocellular Carcinoma Progression and Metastasis: A Dissertation, Leanne G. Ahronian
Activity Regulates Neuronal Connectivity and Function in the C. elegans Motor Circuit: A Dissertation, Belinda Barbagallo
The Recombination Enhancer Modulates the Conformation of Chr. III in Budding Yeast: A Dissertation, Jon-Matthew Belton
Chromatin Regulators and DNA Repair: A Dissertation, Gwendolyn M. Bennett
Regulation of CDK1 Activity during the G1/S Transition in S. cerevisiae through Specific Cyclin-Substrate Docking: A Dissertation, Samyabrata Bhaduri
Regulation of Type II Responses in Lung Fibrosis and Systemic Autoimmunity: A Dissertation, Tia Bumpus Brodeur
Heterologous Immunity and T Cell Stability During Viral Infections: A Dissertation, Jenny Wun-Yue Che
Neural Orchestration of the C. elegans Escape Response: A Dissertation, Christopher M. Clark
A Feedback Loop Couples Musashi-1 Activity to Omega-9 Fatty Acid Biosynthesis: A Dissertation, Carina C. Clingman
Small RNAs and Argonautes Provide a Paternal Epigenetic Memory of Germline Gene Expression to Promote Thermotolerant Male Fertility: A Dissertation, Colin C. Conine
ADHD-200 Patient Characterization and Classification using Resting State Networks: A Dissertation, Suzanne M. Czerniak
Clinical and Financial Impact of Hospital Readmissions Following Colorectal Resection: Predictors, Outcomes, and Costs: A Thesis, Rachelle N. Damle
Hypertensive Acute Decompensated Heart Failure Presentations: On the Decline? : A Master's Thesis, Chad E. Darling
POS-1 Regulation of Endo-mesoderm Identity in C. elegans: A Dissertation, Ahmed M. Elewa
Impact of COPD on the Mortality and Treatment of Patients Hospitalized with Acute Decompensated Heart Failure (The Worcester Heart Failure Study): A Masters Thesis, Kimberly A. Fisher
Psychometric Evaluation of Joint-Specific Patient-Reported Outcome Measures Before and After Total Knee Replacement: A Dissertation, Barbara L. Gandek
Characterization of Anti-Fungal Inflammasome Responses and the Role of Caspase-8 in Innate Immune Signaling: A Dissertation, Sandhya Ganesan
Investigating Tumor Suppressors in the DNA Damage Response: Caretakers of the Genome and Biomarkers to Predict Therapeutic Response: A Dissertation, Shawna S. Guillemette
Cognitive Status and Initiation of Lifestyle Changes Following Acute Coronary Heart Syndrome: A Dissertation, Alexandra M. Hajduk
Characterization of the Visceral Endoderm Components in Early Post-Implantation Mouse Embryo Development: A Dissertation, Tingting Huang
Dissecting cis and trans Determinants of Nucleosome Positioning: A Dissertation, Amanda L. Hughes
Amphiphilic Degradable Polymer/Hydroxyapatite Composites as Smart Bone Tissue Engineering Scaffolds: A Dissertation, Artem B. Kutikov
EspFU, an Enterohemorrhagic E. Coli Secreted Effector, Hijacks Mammalian Actin Assembly Proteins by Molecular Mimicry and Repetition: A Dissertation, YuShuan (Cindy) Lai
Mechanistic Analysis of Differential Signal Transduction Mediated by the Insulin Receptor Substrate Proteins IRS-1 and IRS-2: A Dissertation, Justine M. Landis
Outpatient Emergency Department Utilization: Measurement and Prediction: A Dissertation, Lisa M. Lines
An Integrated Structural Mechanism for Relief of Autoinhibition and Membrane Targeting in Cytohesin Family Guanine Nucleotide Exchange Factors: A Dissertation, Andrew W. Malaby
Identification of Molecular Determinants that Shift Co- and Post-Translational N-Glycosylation Kinetics in Type I Transmembrane Peptides: A Dissertation, Heidi L. H. Malaby
MIRAGE DNA Transposon Silencing by C. elegans Condensin II Subunit HCP-6: A Masters Thesis, Anna Malinkevich
Complex Roles of Macrophages in Lipid Metabolism and Metabolic Disease: A Dissertation, Kimberly A. Negrin
Early Folding Biases in the Folding Free-Energy Surface of βα-Repeat Proteins: A Dissertation, Robert P. Nobrega
Differences in Access to Care and Healthcare Utilization Among Sexual Minorities: A Master's Thesis, Tan Phu Pham
GLI-IKBKE Requirement In KRAS-Induced Pancreatic Tumorigenesis: A Dissertation, Mihir S. Rajurkar
Depression in Rheumatoid Arthritis and an Estimation of the Bi-directional Association of Depression and Disease Burden: A Dissertation, Alan M. Rathbun
Role of Mycobacterium Tuberculosis-Induced Necrotic Cell Death of Macrophages in the Pathogenesis of Pulmonary Tuberculosis: A Dissertation, Teresa S. Repasy
Analyses of All Possible Point Mutations within a Protein Reveals Relationships between Function and Experimental Fitness: A Dissertation, Benjamin P. Roscoe
Putting the Pieces Together: Exons and piRNAs: A Dissertation, Christian K. Roy
FUS/TLS in Stress Response - Implications for Amyotrophic Lateral Sclerosis: A Dissertation, Reddy Ranjith Kumar Sama
Evolutionary Approaches to the Study of Small Noncoding Regulatory RNA Pathways: A Dissertation, Alfred T. Simkin
Role of Hdac3 in Murine Coronary Vessel Development: A Master's Thesis, Kevin M. Smee
The Three-Dimensional Structure of the Cystic Fibrosis Locus: A Dissertation, Emily M. Smith
Comparative Effectiveness of Lithium and Valproate for Suicide Prevention and Associations With Nonsuicide Mortality: A Dissertation, Eric G. Smith
Characterization of Innate Immune Pathways in DNA Vaccine-Induced, Antigen-Specific Immune Responses: A Dissertation, John J. Suschak III
Higher-Order Unfolding of Peri/Centric Satellite Heterochromatin is an Early and Consistent Event in Cell Senescence: A Dissertation, Eric C. Swanson
Role of Astrocytes in Sculpting Neuronal Circuits in the Drosophila CNS: A Dissertation, Ozge E. Tasdemir-Yilmaz
Dissecting the Role of Cytosolic Nucleic Acid Sensors in the Type I Interferon Response to Herpes Simplex Virus-1 and other Ligands: A Dissertation, Mikayla R. Thompson
CD8+ T Cell and NK Responses to a Novel Dengue Epitope: A Possible Role for KIR3DL1 in Dengue Pathogenesis: A Dissertation, Elizabeth Townsley
Developing Three New Pathophysiologically Based Measures of Nicotine Dependence: A Dissertation, W. W. Sanouri A. Ursprung
The Cellular Consequences of FUS/TLS Depletion: A Loss of Function Model for Amyotrophic Lateral Sclerosis: A Dissertation, Catherine L. Ward
Approaches and Considerations Towards a Safe and Effective Adeno-Associated Virus Mediated Therapeutic Intervention for GM1-Gangliosidosis: A Dissertation, Cara M. Weismann
Oncogene Function in Pre-Leukemia Stage of INV(16) Acute Myeloid Leukemia: A Dissertation, Liting Xue
Molecular Landscape of Induced Reprogramming: A Dissertation, Chao-Shun Yang
Studies of HLA-DM in Antigen Presentation and CD4+ T Cell Epitope Selection: A Dissertation, Liusong Yin
Publications from 2013
Local Macrophage Proliferation in Adipose Tissue Is a Characteristic of Obesity-Associated Inflammation: A Dissertation, Shinya U. Amano
Regulation of Higher Order Chromatin at GRIN2B and GAD1 Genetic Loci in Human and Mouse Brain: A Dissertation, Rahul Bharadwaj
A Role for Intraflagellar Transport Proteins in Mitosis: A Dissertation, Alison R. Bright
Disparate Activation of the Inflammasome by Chitin and Chitosan: A Dissertation, Chelsea L. Bueter
Adjuvant-Specific Serum Cytokine Profiles in the Context of a DNA Prime-Protein Boost HIV-1 Vaccine: A Dissertation, Rachel Buglione-Corbett
Layered Reward Signalling Through Octopamine and Dopamine in Drosophila: A Dissertation, Christopher J. Burke
A Novel Autophagy Regulatory Mechanism that Functions During Programmed Cell Death: A Dissertation, Tsun-Kai Chang
The Study of Two Strategies for Decreasing Mutant Huntingtin: Degradation by Puromycin Sensitive AminoPeptidase and RNA Interference: A Dissertation, Joanna Chaurette
Expanding the Known DNA-binding Specificity of Homeodomains for Utility in Customizable Sequence-specific Nucleases: A Dissertation, Stephanie W. Chu
On Identifying Signatures of Positive Selection in Human Populations: A Dissertation, Jessica L. Crisci
Nuclear Organization in Breast Cancer: A Dissertation, Jason R. Dobson
Itk is a Dual Action Regulator of Immunoreceptor Signaling in the Innate and Adaptive Immune System: A Dissertation, John W. Evans III
Genetic Deficiency of CD40 in Mice Exacerbates Metabolic Manifestations of Diet-induced Obesity: A Dissertation, Chang-An Guo
Modulating Influenza and Heparin Binding Viruses’ Pathogenesis with Extrinsic Receptor Decoy Liposomes: A Dissertation, Gabriel L. Hendricks
Experimental Illumination of Comprehensive Fitness Landscapes: A Dissertation, Ryan T. Hietpas
Structure-based Targeting of Transcriptional Regulatory Complexes Implicated in Human Disease: A Dissertation, Brendan J. Hilbert
Suppressive Oligodeoxynucleotides Inhibit Cytosolic DNA Sensing Pathways: A Dissertation, John J. Kaminski III
Tissue-dependent T Cell Apoptosis and Transcriptional Regulation of Memory CD8+T Cell Differentiation During Viral Infections: A Dissertation, Varun N. Kapoor
Modulators of the Acute Inflammatory Response: A Dissertation, Dipti Karmarkar
The Role of Heterologous Immunity in Viral Co-Infections and Neonatal Immunity: A Dissertation, Laurie L. Kenney
Role of Inflammation in Diet-Induced Obesity: A Dissertation, Sophia Kogan
Role of Autophagy in Post-Mitotic Midbody Fate and Function: A Dissertation, Tse-Chun Kuo
Human Cytomegalovirus Reprograms the Expression of Host Micro-RNAs whose Target Networks are Required for Viral Replication: A Dissertation, Alexander N. Lagadinos
Runx Expression in Normal and Osteoarthritic Cartilage: Possible Functions of Runx Proteins in Chondrocytes: A Dissertation, Kimberly T. LeBlanc
Understanding Neural Networks in Awake Rat by Resting-State Functional MRI: A Dissertation, Zhifeng Liang
Transcriptional and Translational Mechanisms Controlling Circadian Rhythms in Drosophila: A Dissertation, Jinli Ling
The Effects of Family and Social Engagement on the Screen Time of Youth with Developmental Disabilities: A Dissertation, Charmaine B. Lo
The Role and Regulation of Etv2 in Zebrafish Vascular Development: A Dissertation, John C. Moore
Elucidating the Molecular Mechanism of CYLD-Mediated Necrosis: A Dissertation, David M. Moquin
Role of the Cytoplasmic Polyadenylation Element Binding Proteins in Neuron: A Dissertation, Aparna Oruganty
dSarm/Sarm1 Governs a Conserved Axon Death Program: A Dissertation, Jeannette M. Osterloh
Structure and Dynamics of Viral Substrate Recognition and Drug Resistance: A Dissertation, Aysegul Ozen
The Role of Ion Channels in Coordinating Neural Circuit Activity in Caenorhabditis elegans: A Dissertation, Jennifer K. Pirri
Investigation of Multiple Concerted Mechanisms Underlying Stimulus-induced G1 Arrest in Yeast: A Dissertation, Patricia A. Pope
The Role of Inducible T Cell Kinase (Itk) in the Development of Innate T Cells and in the Formation of Protective Memory Responses: A Dissertation, Amanda L. Prince
HIV-1 and the Nucleolus: A Role for Nucleophosmin/NPM1 in Viral Replication: A Dissertation, Tracy E. Schmidt
Investigating Cancer Molecular Genetics using Genome-wide RNA Interference Screens: A Dissertation, Ryan W. Serra
Application of a Naïve Bayes Classifier to Assign Polyadenylation Sites from 3' End Deep Sequencing Data: A Dissertation, Sarah E. Sheppard
A Role for Neuronal Nicotinic Acetylcholine Receptors in Dopamine-Mediated Behaviors and the Hypnotic Response to Anesthetics: A Dissertation, Lindsey G. Soll
The Notch1-c-Myc Pathway Mediates Leukemia-Initiating Cell Activity in Mouse T-ALL Models: A Dissertation, Jessica M. Tesell
Inflammasomes and the Innate Immune Response Against Yersinia Pestis: A Dissertation, Gregory I. Vladimer
Identification and Analysis of the Domain Required for Trans-Acceleration Kinetics in the Human Glucose Transporter GLUT1: A Dissertation, Sabrina S. Vollers
Role of Map4k4 in Skeletal Muscle Differentiation: A Dissertation, Mengxi Wang
RNA Interference by the Numbers: Explaining Biology Through Enzymology: A Dissertation, Liang Meng Wee
hox Gene Regulation and Function During Zebrafish Embryogenesis: A Dissertation, Steven E. Weicksel
Morphogenetic Requirements for Embryo Patterning and the Generation of Stem Cell-derived Mice: A Dissertation, Yeonsoo Yoon
A Novel Role of UAP56 in piRNA Mediated Transposon Silencing: A Dissertation, Fan Zhang
piRNA Biogenesis and Transposon Silencing in Drosophila: A Dissertation, Zhao Zhang
Publications from 2012
Mechanisms of KRAS-Mediated Pancreatic Tumor Formation and Progression: A Dissertation, Victoria A. Appleman
Hepatitis C Virus Non-Structural Protein 3/4A: A Tale of Two Domains: A Dissertation, Cihan Aydin
The Subtype Specific and Cross-Reactive T Cell Responses to Influenza Viruses in Humans: A Dissertation, Jenny Aurielle B. Babon
Gene Expression and Profiling of Human Islet Cell Subtypes: A Master’s Thesis, David M. Blodgett
Understanding Small RNA Formation in Drosophila Melanogaster: A Dissertation, Elif Sarinay Cenik
Localization of Insulin Receptor Substrate-2 in Breast Cancer: A Dissertation, Jennifer L. Clark
Transcriptional Regulation of the Interleukin-8 Promoter by Multiple Dengue Viral Proteins: A Dissertation, Jacob M. Collins
Psychosocial and Behavioral Determinants of Medication Nonadherence Among African Americans with Hypertension: A Dissertation, Yendelela L. Cuffee
Runx1 C-terminal Domains During Hematopoietic Development and Leukemogenesis: A Dissertation, Christopher R. Dowdy
On the Source of Peptides for Major Histocompatibility Class I Antigen Presentation: A Dissertation, Diego José Farfán Arribas
Sequence and Target Specificity of the C. elegans Cell Fate Specification Factor POS-1: A Dissertation, Brian M. Farley
Role of Perivascular and Visceral Adipose Tissues in Murine Models of Obesity and Atherosclerosis: A Dissertation, Timothy P. Fitzgibbons
Building the Cell's Antenna: Protein Targeting to the Ciliary Membrane: A Dissertation, John A. Follit
Role of Glia in Sculpting Synaptic Connections at the Drosophila Neuromuscular Junction: A Dissertation, Yuly F. Fuentes Medel
Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation, Hugh S. Gannon
Analysis of Integrin α6β4 Function in Breast Carcinoma: A Dissertation, Kristin D. Gerson
Getting a Tight Grip on DNA: Optimizing Zinc Fingers for Efficient ZFN-Mediated Gene Editing: A Dissertation, Ankit Gupta
Characterization of Drug Resistance in Mycobacterium Tuberculosis via Saturating Mutagenesis of Drug Targets: A Master’s Thesis, Michelle J. Harris
Serotonin-Expressing Cells in the Corpus of the Stomach Originate from Bone Marrow: A Master’s Thesis, Brian T. Johnston
Gene Therapy for Very Long Chain Acyl-coA Dehydrogenase Deficiency Using Adeno-Associated Virus Vectors: A Dissertation, Allison M. Keeler
Glial Control of Synapse Assembly at the Drosophila Neuromuscular Junction: A Dissertation, Kimberly S. Kerr
The Role of Adaptor Protein Complex-3 Delta-Mediated HIV-1 Gag Trafficking in HIV-1 Replication: A Dissertation, Adonia Lee Kim
A Novel Communication Mechanism Between the Presynapse and Postsynapse Through Exosomes: A Dissertation, Ceren Korkut
Protein Ligand Interactions Probed by NMR: A Dissertation, Jennifer M. Laine
Catalytic Mechanisms in Sec7 and Vps9 Domain Exchange Factors for Arf and Rab GTPases: A Dissertation, Meng-Tse Lee
Studies on the Regulation of Cytoplasmic Polyadenylation Element-Binding Protein: A Dissertation, Chien-Ling Lin
Genetic Approaches to Study Transcriptional Activation and Tumor Suppression: A Dissertation, Ling Lin
Dissecting Somatic Cell Reprogramming by MicroRNAs and Small Molecules: A Dissertation, Zhonghan Li
Targeting the Histone Acetyl-Transferase, RTT109, for Novel Anti-Fungal Drug Development: A Dissertation, Jessica Lopes da Rosa-Spiegler
A Role for c-Jun Kinase (JNK) Signaling in Glial Engulfment of Degenerating Axons: A Dissertation, Jennifer M. MacDonald
RNA-Sensing Pattern Recognition Receptors and Their Effects on T-Cell Immune Responses: A Dissertation, Rachel F. Madera
Distinct Gene Circuits Control the Differentiation of Innate Versus Adaptive IL-17 Producing T Cells: A Dissertation, Nidhi Malhotra
Inflammation Inhibits Osteoblast-Mediated Bone Formation in Rheumatoid Arthritis and Regulates the Wnt and BMP Signaling Pathways: A Dissertation, Melissa M. Matzelle
Incidence, prognosis, and factors associated with cardiac arrest in patients hospitalized with acute coronary syndromes (the GRACE Registry): A master's thesis, David D. McManus
Characterization of New Factors in the 18S Nonfunctional Ribosomal RNA Decay Pathway in S. cerevisiae: A Dissertation, Christopher N. Merrikh
Slow-Cycling Cancer Cells: A Dissertation, Nathan F. Moore
Small Molecule Investigation of KCNQ Potassium Channels: A Dissertation, Karen Mruk
Lack of CFTR in CD3+ Lymphocytes Leads to Aberrant Cytokine Secretion and Hyper-Inflammatory Adaptive Immune Responses: A Master's Thesis, Christian Mueller
HIV-1 R5 Tropism: Determinants, Macrophages, and Dendritic Cells: A Dissertation, Thomas A. Musich
Molecular Mechanisms of Endocytosis: Trafficking and Functional Requirements for the Transferrin Receptor, Small Interfering RNAs and Dopamine Transporter: A Dissertation, Deanna M. Navaroli
TXNIP is a Mediator of ER Stress-Induced β-Cell Inflammation and Apoptosis: A Dissertation, Christine M. Oslowski
Contribution of WFS1 to Pancreatic Beta Cell Survival and Adaptive Alterations in WFS1 Deficiency: A Dissertation, Bryan M. O'Sullivan-Murphy
Transposition Driven Genomic Heterogeneity in the Drosophila Brain: A Dissertation, Paola N. Perrat
Maintaining the Balance: Coordinating Excitation and Inhibition in a Simple Motor Circuit: A Dissertation, Hilary A. Petrash
Therapeutic Silencing of Mutant Huntingtin by Targeting Single Nucleotide Polymorphisms: A Dissertation, Edith L. Pfister
Control of Bovine Papillomavirus E2 Function By Acetylation and the Novel E2 Interacting Protein RINT1: A Dissertation, Edward J. Quinlan
Antagonistic Pleiotropy: The Role of Smurf2 in Cancer and Aging: A Dissertation, Charusheila Ramkumar
Innate Signaling Pathways in the Maintenance of Serological Memory: A Dissertation, Forum M. Raval
Studies on Cellular Host Factors Involved in the HIV-1 Life Cycle: A Dissertation, Anna Kristina Serquiña
Molecular Studies of T Cell Recognition and Cross-Reactivity: A Dissertation, Zu T. Shen
Mechanical Activation of Valvular Interstitial Cell Phenotype: A Dissertation, Angela M. Throm Quinlan
An Extra-Embryonic Wnt Signaling Event Controls Gastrulation in Mice: A Dissertation, Giovane G. Tortelote
Origin of White and Brown Adipose Cells From Vascular Endothelium: A Dissertation, Khanh-Van T. Tran
Primary and Secondary Immune Responses During Sequential West Nile Virus and Japanese Encephalitis Virus Infections: A Dissertation, Derek W. Trobaugh
MicroRNA Markers of Acetaminophen Toxicity: A Master's Thesis, Jeanine Ward
The Role of Heterologous Immunity in Mediating Natural Resistance to Infection in Human Subjects: A Dissertation, Levi B. Watkin
Investigating the Roles of NEDD4.2s and Nef in the Release and Replication of HIV-1: A Dissertation, Eric R. Weiss
Chromatin Dynamics in Pluripotency and Differentiation: A Dissertation, Ozlem Yildirim
The Role of ITK in the Development of Gamma Delta NKT Cells: A Dissertation, Catherine C. Yin
The Molecular Mechanisms for Maintenance of Cancer Stem Cells in Chronic Myeloid Leukemia: A Dissertation, Haojian Zhang
Eaters of the Dead: How Glial Cells Respond to and Engulf Degenerating Axons in the CNS: A Dissertation, Jennifer S. Ziegenfuss
Publications from 2011
Use of Multinational Registries to Assess and Compare Outcomes of Patients with an Acute Coronary Syndrome: A Dissertation, Hamza H. Awad
Investigation of the C-Terminal Helix of HIV-1 Matrix: A Region Essential for Multiple Functions in the Viral Life Cycle: A Dissertation, Laura A. Brandano
Cooperativity in Mammalian RNA Silencing: A Dissertation, Jennifer A. Broderick
Intestine Homeostasis and the Role of Tumor Suppressor Gene 101 in Drosophila Melanogaster: A Dissertation, Madhurima Chatterjee
Asymmetric Inheritance and Post-mitotic Fate of Midbodies: A Dissertation, Chun-Ting Chen
Nuclear Import of Smad: A Dissertation, Xiaochu Chen
Critical Molecular Pathways in Cancer Stem Cells of Chronic Myeloid Leukemia: A Dissertation, Yaoyu Chen
Inflammation Alters Histone Methylation in the Central Nervous System: Implications for Neuropsychiatric Disease: A Dissertation, Caroline M. Connor
The Role of miR-21 and miR-31 in Cellular Responses Mediated by TGF-β: A Dissertation, Charisa L. Cottonham
Cellular and Molecular Mechanisms Driving Glial Engulfment of Degenerating Axons: A Dissertation, Johnna E. Doherty
Tyraminergic G Protein-Coupled Receptors Modulate Locomotion and Navigational Behavior In C. Elegans: A Dissertation, Jamie L. Donnelly
Quantitative Analysis of Novel Chemical and shRNA Based Methods to Increase Survival of Motor Neuron Protein Levels, Matthew C. Evans
Biomimetic Synthetic Tissue Scaffolds for Bone Regeneration: A Dissertation, Tera M. Filion Potts
Factors Associated with Ordering and Completion of Laboratory Monitoring Tests for High-Risk Medications in the Ambulatory Setting: A Dissertation, Shira H. Fischer
Identification of a Command Neuron Directing the Expression of Feeding Behavior in Drosophila melanogaster: A Dissertation, Thomas F. Flood
Blocking the Notch Pathway with Gamma-Secretase Inhibitors Enhances Temozolomide Treatment of Gliomas through Therapy-Induced Senescence: A Dissertation, Candace A. Gilbert
A Global Analysis of the Adaptations Required for Sterol Catabolism in Mycobacterium Tuberculosis: A Dissertation, Jennifer E. Griffin
Role of the Yeast Ste20 Protein Kinase Ortholog Map4k4 in Adipose Tissue Function: A Dissertation, Kalyani V. P. Guntur
Dissecting Signaling Pathways that Regulate Axonal Guidance Effects of Sonic Hedgehog: A Dissertation, Daorong Guo
M.tb Killing by Macrophage Innate Immune Mechanisms: A Dissertation, Michelle L. Hartman
Using Light to Observe and Control Cellular Function: Improving Bioluminescence Imaging and Photocontrol of Rho GTPase Activation States: A Dissertation, Katryn R. Harwood
Neuronal Nicotinic Acetylcholine Receptors: Molecular Targets for Alcoholism and Ethanol Reward: A Dissertation, Linzy M. Hendrickson
Regulation and Function of Neuronal Nicotinic Acetylcholine Receptors in Lung Cancer: A Dissertation, Ma. Reina D. Improgo
Molecular and Functional Properties of Transmitted HIV-1 Envelope Variants: A Dissertation, Michael G. Kishko
Dynamics of Erythropoietic Survival Pathways In Vivo: A Dissertation, Miroslav Koulnis
Molecular Mechanisms of piRNA Biogenesis and Function in Drosophila: A Dissertation, Chengjian Li
Neuronal Diversification in the Postembryonic Drosophila Brain: A Dissertation, Suewei Lin
Critical and Independent Roles of the P/CAF Acetyltransferase in ARF-p53 Signaling: A Dissertation, Ian M. Love
Cooperating Events in Core Binding Factor Leukemia Development: A Dissertation, Dmitri Madera
Insulin Receptor Substrate-2 (IRS-2): A Novel Hypoxia-Responsive Gene in Breast Cancer: A Dissertation, Katerina Mardilovich
Cannabis Use and Bipolar Disorder: Bipolar Disorder Case Identification and Cannabis Use Risk Assessment: A Dissertation, Patrick J. McCabe
A Tale of Two SNPS: Polymorphism Analysis of Toll-like Receptor (TLR) Adapter Proteins: A Dissertation, Kamalpreet Nagpal
The Function of Innate γδ T Cell Subsets is Molecularly Programmed in the Thymus in Three Stages: A Dissertation, Kavitha Narayan
The Importance of the Centrosomal Localization Sequence of Cyclin E for Promoting Centrosome Duplication: A Dissertation, Joshua J. Nordberg
Telomere Length Dynamics in Human T Cells: A Dissertation, Joel M. O'Bryan
Conformational Lability in MHC II Proteins: A Dissertation, Corrie A. Painter
Regulation of Runx Proteins in Human Cancers: A Dissertation, Sandhya Pande
Digital and Analog STAT5 Signaling in Erythropoiesis: A Dissertation, Ermelinda Porpiglia
Hsp90-Mediated Maturation of Kinases and Nuclear Steroid Hormone Receptors: A Dissertation, Natalie W. Pursell
Mechanisms of Substrate Recognition by HCV NS3/4A Protease Provide Insights Into Drug Resistance: A Dissertation, Keith P. Romano
Roles of Secreted Virulence Factors in Pathogenicity of Haemophilus Influenzae: A Dissertation, Charles V. Rosadini
Herbal Marijuana Alternatives Investigation: K2 and Spice: A Masters Thesis, Christopher D. Rosenbaum
Support of Mitochondrial DNA Replication by Human Rad51: A Dissertation, Jay M. Sage
Structural Studies of the Anti-HIV Human Protein APOBEC3G Catalytic Domain: A Dissertation, Shivender Shandilya
Global DNA Demethylation During Erythropoiesis: A Dissertation, Jeffrey R. Shearstone
Nucleic Acid Sensing by the Immune System: Roles For the Receptor For Advanced Glycation End Products (RAGE) and Intracellular Receptor Proteins: A Dissertation, Cherilyn M. Sirois
Chromosome-Biased Binding and Function of C. elegans DRM Complex, and Its Role in Germline Sex-Silencing: A Dissertation, Tomoko M. Tabuchi
Insights Into ER Translocation Channel Gating. Structural Regulation of the Transition Between the Closed and Open Channel Conformations: A Dissertation, Steven F. Trueman
Two Distinct Modes of Signaling by Vascular Endothelial Growth Factor C Guide Blood and Lymphatic Vessel Patterning in Zebrafish: A Dissertation, Jacques A. Villefranc
Treating GM1 Gangliosidosis With Ex Vivo Hematopoietic Stem Cell Gene Therapy Without Using Total Body Irradiation: A Masters Thesis, Michael Whalen
Regulation of Humoral Immunity by Pim Kinases: A Dissertation, Kristen N. Willems
Dissection of α6β4 Integrin-Dependent Signaling and Breast Carcinoma Invasion: A Dissertation, Xiaoqing Yang
Investigating Age-Dependent Arthropathy in a Circadian Mutant Mouse Model: A Dissertation, Elizabeth A. Yu
The Role of PC4 in Oxidative Stress: A Dissertation, Lijian Yu
Improved Methods of Sepsis Case Identification and the Effects of Treatment with Low Dose Steroids: A Dissertation, Huifang Zhao
Publications from 2010
A View of the IMD Pathway from the RHIM, Kamna Aggarwal
C. Elegans Metabolic Gene Regulatory Networks: A Dissertation, H. Efsun Arda
Axon Death Prevented: Wlds and Other Neuroprotective Molecules: A Dissertation, Michelle A. Avery
Exploring Molecular Mechanisms of Drug Resistance in HIV-1 Protease through Biochemical and Biophysical Studies: A Dissertation, Rajintha M. Bandaranayake
Host Cell Attachment by Lyme Disease and Relapsing Fever Spirochetes: A Dissertation, Vivian M. Benoit
Development and Evaluation of Disease Activity Measures in Rheumatoid Arthritis Using Multi-Level Mixed Modeling and Other Statistical Methodologies: A Dissertation, Mary Jane Bentley
Energy Metabolism and the Induction of the Unfolded Protein Response: A Dissertation, Alison M. Burkart
Post-Transcriptional Control of Human Cellular Senescence: A Dissertation, David M. Burns
Role of the cJun NH2-Terminal Kinase (JNK) in Cancer: A Dissertation, Cristina Arrigo Cellurale
Glycosylation, Assembly and Trafficking of Cardiac Potassium Channel Complexes: A Dissertation, Kshama D. Chandrasekhar
Regulation of Immune Pathogenesis by Antigen-Specific CD8 T Cells Following Sequential Heterologous Infections: A Dissertation, Alex T. Chen
Generating Nucleosomal Asymmetry in Saccharomyces cerevisiae: A Masters Thesis, Yuanyuan Chen
The Role of Dynamic Cdk1 Phosphorylation in Chromosome Segregation in Schizosaccharomyces pombe: A Dissertation, Sung Hugh Choi
Development of a Multi-Site Phase II Clinical Trial of Valproic Acid for Retinitis Pigmentosa, Christine Moulton Clemson
Acute Modulation of Endothelial Cell Glucose Transport: A Dissertation, Anthony J. Cura
A Novel Motif in HIV-1 Nef that Regulates MIP-1β Chemokine Release in Macrophages: A Dissertation, Lue Dai
An Integral Role of ARRDC3 in Stem Cell Migration and Breast Cancer Progression: A Dissertation, Kyle M. Draheim
Novel Complement Blocking Antibodies Against Serogroup B N. meningitidis: A Dissertation, Tathagat Dutta Ray
CD8+ T Cell Serotype-Cross-Reactivity is a Predominant Feature of Dengue Virus Infections in Humans: A Dissertation, Heather L. Friberg-Robertson
Endogenous Small RNAs in the Drosophila Soma: A Dissertation, Megha Ghildiyal
Transcriptional Regulation of VEGFA by Unfolded Protein Response Signaling Pathway, Rajarshi Ghosh
Cross-Talk Between Factors Involved in mRNA Translation and Decay: A Dissertation, Shubhendu Ghosh
A Glia-Mediated Feedback Mechanism for the Termination of Drosophila Visual Response: A Dissertation, Peiyi Guo
Role of the Monocyte/Macrophage Cell Lineage in Obesity-Related Insulin Resistance, Olga T. Hardy
Maternally Derived Anti-Dengue Antibodies and Risk of DHF in Infants: A Case-Control Study, Steven Hatch
Role of CPEB in Senescence and Inflammation: A Dissertation, Maria Ivshina
Sequence Determinants of the Folding Free-Energy Landscape of beta alpha-Repeat Proteins: A Dissertation, Sagar V. Kathuria
The Coupling Between Folding, Zinc Binding, and Disulfide Bond Status of Human Cu, Zn Superoxide Dismutase: A Dissertation, Can Kayatekin
Drosophila piRNA Function in Genome Maintenance, Telomere Protection and Genome Evolution: A Dissertation, Jaspreet S. Khurana
Role of Internal Calcium Stores in Exocytosis and Neurotransmission: A Dissertation, Jason J. Lefkowitz
Behavioral Health Disorders and the Quality of Diabetes Care: A Dissertation, Yat (Gary) Hung Leung
Clinically Relevant Doses of Chemotherapy Drugs Selectively and Reversibly Block Glioblastoma Neurosphere Proliferation in vitro: A Dissertation, Alicia M. Mihaliak
Converging Pathways in the Regulation of Longevity and Metabolism in Caenorhabditis Elegans: A Dissertation, Sri Devi Narasimhan
Structural and Functional Studies of Proteins Involved in Antigen Processing: A Dissertation, Tina T. Nguyen
Maintenance of Visual Sensitivity in the Drosophila Eye: A Dissertation, Lina Ni
Regulation of Cellular and HIV-1 Gene Expression by Positive Transcription Elongation Factor B: A Dissertation, Siobhan O'Brien
RNA Recognition by the Caenorhabditis elegans Embryonic Determinants MEX-5 and MEX-3: A Dissertation, John M. Pagano Jr.