GSBS Dissertations and Theses

 

Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

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Publications from 2018

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The Tec kinase ITK is required for homeostasis and anti-viral immune protection in the intestine, Hyoung-Soo Cho

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Illuminating Biology with Membrane Penetrating Sulfonate Delivery Scaffolds and Near-Infrared Azasiline Fluorophores, Adam Choi

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Chemically Modified Oligonucleotides Silence Mutant SPTLC1 in an in vitro Model of HSAN1, Havisha Bindu Karnam

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Investigation of LIN-28 Function in Somatic Gonadal Development and Fertility, and Characterization of the LIN-28 Isoforms in C. elegans Hermaphrodites, Sungwook Choi

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FUS and Excitotoxicity Cross Paths in ALS: New Insights into Cellular Stress and Disease, Maeve Tischbein

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Predictors of Patient Activation at ACS Hospital Discharge and Health Care Utilization in the Subsequent Year, Rebecca L. Kinney

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Integrated Analysis of miRNA/mRNA Expression in the Neurocircuitry Underlying Nicotine Dependence, Alison P. Casserly

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Understanding Nuage-mitochondrial Coupling in Drosophila piRNA Biogenesis, Tianfang Ge

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SERINC5: Its Sensitivity to Nef and Restriction of HIV-1, Weiwei Dai

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RIPPLiT and ChimeraTie: High throughput tools for understanding higher order RNP structures, Mihir Metkar

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Innate Detection of HIV-1 in Myeloid Dendritic Cells, Sean Matthew McCauley

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Inebriated Immunity: Alcohol Affects Innate Immune Signaling in the Gut-Liver-Brain Axis, Patrick P. Lowe

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PIE-1, SUMOylation, and Epigenetic Regulation of Germline Specification in Caenorhabditis elegans, Heesun Kim

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Adipocyte mTORC1 Signaling Separately Regulates Metabolic Homeostasis and Adipose Tissue Mass, Independent of RagGTPase Activity, Peter L. Lee

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Studies in Antigen Presentation and Antigen Recognition at Different Interfaces of the Adaptive Immune System, Maria P. Negroni

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The Role of Eukaryotic ABC-Transporters in Eliciting Neutrophil infiltration during Streptococcus pneumoniae infection, Andrew Zukauskas

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Ventricular Arrhythmias Complicating Coronary Artery Disease: Recent Trends, Risk Associated with Serum Glucose Levels, and Psychological Impact, Hoang V. Tran

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Investigating the Gene Regulatory Network Underlying Caudal Hindbrain Specification in Embryonic Zebrafish, Priyanjali Ghosh

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National Trends in Elective Ileal Pouch-Anal Anastomosis for Ulcerative Colitis, Chau Maggie Hoang

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Adaptive Evolution of piRNA pathway in Drosophila, Swapnil S. Parhad

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Engineered Exosomes for Delivery of Therapeutic siRNAs to Neurons, Reka A. Haraszti

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An Examination of MHC, Peptide, and TCR Interactions, Peter Trenh

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Follow Your Heart: Evaluating Cardiac Function to Predict Outcomes Among ICU Patients with Traumatic Brain Injury, Patric Gibbons

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Innate Immune Signaling Drives Pathogenic Events Leading to Autoimmune Diabetes, Natasha Qaisar

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Maelstrom Represses Canonical RNA Polymerase II Transcription in Drosophila Dual-Strand piRNA Clusters, Timothy H. Chang

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Targeting Drug Resistance In HCV NS3/4A Protease: Mechanisms And Inhibitor Design Strategies, Ashley N. Matthew

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Evaluating Multi-Level Factors Influencing Adolescent Sugar Sweetened Beverage Consumption, Christina F. Griecci

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Opioid Use and Safety in United States Nursing Homes, Jacob N. Hunnicutt

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A suite of computational tools to interrogate sequence data with local haplotype analysis within complex ​Plasmodium​ infections and other microbial mixtures, Nicholas J. Hathaway

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Role of TRIP6 and Angiomotins in the Regulation of the Hippo Signaling Pathway, Shubham Dutta

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Antigen Specific CD4+ and CD8+ T Cell Recognition During Mycobacterium Tuberculosis Infection, Jason D. Yang

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Clostridium difficile Colonization and Infection in the Elderly and Associations with the Aging Intestinal Microbiome, John P. Haran

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The cJUN NH2-terminal kinase pathway in mammary gland biology and carcinogenesis, Nomeda A. Girnius

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Molecular Mechanisms Underlying Synaptic Connectivity in C. elegans, Alison M. Philbrook

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Identification of Novel Genetic Variations for Amyotrophic Lateral Sclerosis (ALS), Guang Xu

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Understanding Human Erythrocyte Glucose Transporter (GLUT1) Mediated Glucose Transport Phenomena Through Structural Analysis, Kenneth P. Lloyd

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The Role of NFκB Factor Relish in Developmentally Programmed Cell Death, Anubhab Nandy

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Mechanisms Regulating the Dopamine Transporter and Their Impact on Behavior, Carolyn G. Sweeney

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Watching Sugar Transport in Real Time in Single Cells and Cell Populations, Andrew H. Simon

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RUNX1 Is an Oncogenic Transcription Factor that Regulates MYB and MYC Enhancer Activity in T-ALL, AHyun Choi

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Investigating the Structural Basis for Human Disease: APOBEC3A and Profilin, Tania V. Silvas

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Role of JIP1-JNK Signaling in Beta-Cell Function and Autophagy, Seda Barutcu

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The Role of RIPK1 Kinase Activity in Regulating Inflammation and Necroptotic Death, Matija Zelic

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Antiviral Immune Responses to Invertebrate Iridescent Virus 6 in Drosophila, Cara C. West

Publications from 2017

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Single Molecule Approaches to Mapping DNA Replication Origins, Victor Liu

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Transcriptome-Wide Analysis of Roles for Transfer RNA Modifications in Translational Regulation, Hsin-Jung Chou

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Small Molecule Modulation of GLUT1-Mediated Glucose Transport, Ogooluwa A. Ojelabi

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Adapting the EMPIRIC Approach to Investigate Evolutionary Constraints in Influenza A Virus Surface Proteins, Aneth S. Canale

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Identification of Factors Involved in 18S Nonfunctional Ribosomal RNA Decay and a Method for Detecting 8-oxoguanosine by RNA-Seq, Kelly A. Limoncelli

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Understanding Multiple Independent Functions of the Tip60 Acetyltransferase in Embryonic Development, Diwash Acharya

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Late Antigen Regulates the Differentiation of Cytotoxic CD4 T Cells in Influenza Infection, Allen M. Vong

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Astrocytic regulation of seizure-like behavior, Sukhee Cho

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Membrane Proteins Take Different Trafficking Pathways to the Primary Cilium, William Joseph Monis

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RUNX1 Control of Mammary Epithelial and Breast Cancer Cell Phenotypes, Deli Hong

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Analysis, Visualization, and Machine Learning of Epigenomic Data, Michael J. Purcaro

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The Transcription Factor Pebbled/RREB1 Regulates Injury-Induced Axon Degeneration, Jonathan E. Farley

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Molecular Players in Preserving Excitatory-Inhibitory Balance in the Brain, Wenjie Mao

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A Study of Host Factors that Affect Herpes Simplex Virus 1 Pathogenesis: The Role of Cold Sore Susceptibility Gene 1 (CSSG1) in HSV1 Replication, Milan K. Patel

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Comparative Oncogenomics Identifies Novel Regulators and Clinical Relevance of Neural Crest Identities in Melanoma, Arvind M. Venkatesan

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Development of Chimeric Cas9 Nucleases for Accurate and Flexible Genome Editing, Mehmet F. Bolukbasi

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Use of ClinicalTrials.gov Registry in Systematic Reviews and Meta-analyses: A Master's Thesis, Richeek Pradhan

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Barriers to Healthcare Access and Patient Outcomes After a Hospitalization for an Acute Coronary Syndrome and Other Acute Conditions, Nathaniel A. K. Erskine

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Investigating the Peptide-MHC Specificity of Alloreactive T Cells and Natural T Regulatory Cells Using a Self-peptide Display Library, Brian R. Duke

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Exploring the Role of Large Clusters of Branched Aliphatic Residues on the Folding Free Energy Landscape of (βα)8 TIM Barrel Proteins, Kevin T. Halloran

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Characterization of Adipose Tissue Inflammation in Alcoholic Liver Disease, Melissa A. Fulham

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Identification of KIT as a Suppressor of BRAFV600E-Mutant Melanoma, James V. Neiswender

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Dosage Compensation of Trisomy 21 and Its Implications for Hematopoietic Pathogenesis in Down Syndrome, Jen-Chieh Chiang

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The Complex Role of Sequence and Structure in the Stability and Function of the TIM Barrel Proteins, Yvonne H. Chan

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Innate Immunity As Mediator of Cell Death and Inflammation in Alcoholic Liver Disease, Arvin Iracheta-Vellve

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A Systems Approach to Dissecting Immune Gene Regulatory Networks in the Modulation of Brain Function, Yang Xu

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Regulation of the FGF/ERK Signaling Pathway: Roles in Zebrafish Gametogenesis and Embryogenesis, Jennifer M. Maurer

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Defining a Registry of Candidate Regulatory Elements to Interpret Disease Associated Genetic Variation, Jill E. Moore

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Evaluation of IL2 and HLA on the Homeostasis and Function of Human CD4 and CD8 T Cells, Philip A. Durost

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Ki-67 Regulates Cell Cycle Progression and Heterochromatin Organization, Xiaoming Sun

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Different Journeys, Same Destination: Exploring the Role of a PYHIN Protein and Involvement of Caspase-8 in the Regulation and Activation of Inflammasomes, Sreya Ghosh

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Investigating Structural and Functional Defects in ALS-causing Profilin 1 Variants, Sivakumar Boopathy

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Neuronal circuitry controlling circadian photoreception in Drosophila, Pallavi Lamba

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Platelet Transcriptome Heterogeneity: A Role for RNA Uptake in Vascular Health and Disease, Lauren R. Clancy

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Regulation of Pluripotency and Differentiation by Chromatin Remodeling Factors, Ly-Sha Ee

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Pathways Involved in Recognition and Induction of Trained Innate Immunity by Plasmodium falciparum, Jacob E. Schrum

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Intergenerational Effects of Nicotine in an Animal Model of Paternal Nicotine Exposure, Markus Parzival Vallaster

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Genomic and Transcriptomic Investigation of Endemic Burkitt Lymphoma and Epstein Barr Virus, Yasin Kaymaz

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Regulation of Local Translation, Synaptic Plasticity, and Cognitive Function by CNOT7, Rhonda L. McFleder

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A Two-Pronged Approach to Preeclampsia: Understanding Gene Expression and Targeting sFlt1 using RNAi, Ami Ashar-Patel

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Alterations in mRNA 3′UTR Isoform Abundance Accompany Gene Expression Changes in Huntington's Disease, Lindsay S. Romo

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Role of Tim3 in Mediating T Cell Exhaustion During Chronic Mycobacterium Tuberculosis Infection, Miye K. Jacques

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Regulation of Alloreactive CD8 T Cell Responses by Costimulation and Inflammation, Sonal Jangalwe

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A Mechanistic Investigation of Insulin Receptor Substrate 2 Function in Breast Cancer Progression, Jose R. Mercado-Matos

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Generation of Pharyngeal Foregut Endoderm from Pluripotent Stem Cells, Nicola A. Kearns

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The Role of Skeletal Survey in Identifying Non-Accidental Trauma in Pediatric Trauma Patients, Jonathan Green

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Complement-Related Regulates Autophagy in Neighboring Cells, Lin Lin

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Identification and Characterization of Rab39a and Its Role in Crosspresentation, Freidrich M. Cruz

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Investigating the Role of PIR1 and CD200R1 in the Innate Immune Response to Viral Pathogens, Christopher R. MacKay

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Therapeutic Antibody Against Neisseria gonorrhoeae Lipooligosaccharide, a Phase-variable Virulence Factor, Srinjoy Chakraborti

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Inhibiting Axon Degeneration in a Mouse Model of Acute Brain Injury Through Deletion of Sarm1, Nils Henninger

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Single-Molecule Studies of Replication Kinetics in Response to DNA Damage, Divya Ramalingam Iyer

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Characterization of Severe Malaria in Liberian Children 5 Years Old and Younger, Patricia A. McQuilkin

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mRNA Decay Pathways Use Translation Fidelity and Competing Decapping Complexes for Substrate Selection, Alper Celik

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Three-dimensional Folding of Eukaryotic Genomes, Tsung-Han S. Hsieh

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Recent Trends in Sepsis Mortality, Associations between Initial Source of Sepsis and Hospital Mortality, and Predictors of Sepsis Readmission in Sepsis Survivors, Christine Motzkus

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Behavioral and Functional Analysis of a Calcium Channelopathy in Caenorhaditis elegans, Yung-Chi Huang

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Axon Death Pathways Converge on Axed to Promote Axon Disassembly, Thomas C. Burdett

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Exploring New Therapeutic Strategies for Osteoarthritis: From Genetic Manipulation of Skeletal Tissues to Chemically-modified Synthetic Hydrogels, Henry Huang

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Impact of Intra-Articular Injection Use on Patient-Reported Outcomes Among Patients with Knee Osteoarthritis, Shao-Hsien Liu

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Patient and Social Determinants of Health Trajectories Following Coronary Events, Lisa Nobel

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A Synthetic Genetic System to Investigate Brain Connectivity and Genetically Manipulate Interacting Cells, Ting-Hao Huang

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Regulation of the Drosophila Initiator Caspase Dronc through Ubiquitylation, Hatem E. Kamber Kaya

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Novel Mechanisms Regulating Dopamine Transporter Endocytic Trafficking: Ack1-Controlled Endocytosis And Retromer-Mediated Recycling, Sijia Wu

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Role of Energy Metabolism in the Thermogenic Gene Program, Minwoo Nam

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CAF-1 p150 and Ki-67 Regulate Nuclear Structure Throughout the Human Cell Cycle, Timothy D. Matheson

Publications from 2016

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The Effects of Interleukin-10 on Skeletal Muscle Insulin Resistance and Myogenesis, Sezin Dagdeviren

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Histone Deacetylase 3 Coordinates Heart Development Through Stage-Specific Roles in Cardiac Progenitor Cells, Sara L. Lewandowski

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The Origin of Human White, Brown, and Brite/Beige Adipocytes, So Yun Min

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Temporal Organization of Behavioral States through Local Neuromodulation in C. elegans, Navonil Banerjee

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The Structural Basis for the Interdependence of Drug Resistance in the HIV-1 Protease, Debra A. Ragland

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Sex, Drugs, and Rodent Reward: An Exploration of the Sex-Specific Roles of Nicotinic Acetylcholine Receptors in Ethanol Reward, Melissa Guildford Derner

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Identification of Essential Metabolic and Genetic Adaptations to the Quiescent State in Mycobacterium Tuberculosis: A Dissertation, Emily S. C. Rittershaus

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A Translational Pathway for Recombinant Adeno-Associated Virus Human Gene Therapy: From Target Identification and Animal Modeling of the Disease to Non-Human Primate and Human Studies, Alisha Gruntman

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Targeting Drug Resistance in Chronic Myeloid Leukemia: A Dissertation, Leyuan Ma

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Macrophages Are Regulators of Whole Body Metabolism: A Dissertation, Joseph C. Yawe

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mTORC2 Promotes Lipid Storage and Suppresses Thermogenesis in Brown Adipose Tissue in Part Through AKT-Independent Regulation of FoxO1: A Dissertation, Chien-Min Hung

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Requirement and Function of Hippo Pathway Signaling in the Mammalian Gastrointestinal Tract: A Dissertation, Jennifer L. Cotton

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The Role of Late Antigen in CD4 Memory T Cell Formation during Influena [i.e. Influenza] Infection: A Dissertation, Bianca L. Bautista

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Identification of Novel Pathways that Promote Anoikis through Genome-wide Screens, Victoria E. Pedanou

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FC Receptor-Mediated Activities of Env-Specific Monoclonal Antibodies Generated from Human Volunteers Receiving a DNA Prime-Protein Boost HIV Vaccine: A Dissertation, Matthew R. Costa

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Evaluating Acceptability, Feasibility and Efficacy of a Diabetes Care Support Program Facilitated by Cellular-Enabled Glucose Meters: A Dissertation, Daniel J. Amante

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Histopathological Characterization of the Dystrophic Phenotype and Development of Therapeutic Candidates for a Gene Therapy Pre-Clinical Study in Dysferlin Deficient Mice, Leticia Fridman

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Mechanisms of Synaptic Development and Premature Aging in Drosophila: A Dissertation, Yihang Li

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Overcoming Toxicity from Transgene Overexpression Through Vector Design in AAV Gene Therapy for GM2 Gangliosidoses, Diane L. Golebiowski

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Viral Proteases as Drug Targets and the Mechanisms of Drug Resistance: A Dissertation, Kuan-Hung Lin

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Functions of Argonaute Proteins in Self Versus Non-Self Recognition in the C. elegans Germline: A Dissertation, Meetu Seth

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Investigation of RNA Binding Protein Pumilio as a Genetic Modifier of Mutant CHMP2B in Frontotemporal Dementia (FTD): A Masters Thesis, Xing Du

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Tissue Compartmentalization and Tropism of HIV-1: A Dissertation, Robin L. Brese

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Levels of YCG1 Limit Condensin Function during the Cell Cycle: A Dissertation, Tyler W. Doughty

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Exploiting DNA Repair and ER Stress Response Pathways to Induce Apoptosis in Glioblastoma Multiforme: A Dissertation, Jessica L. Weatherbee

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Roles of the Mother Centriole Appendage Protein Cenexin in Microtubule Organization during Cell Migration and Cell Division: A Dissertation, Hui-Fang Hung

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The Role of MDM2 Phosphorylation in P53 Responses to DNA Damage and Tumor Suppression: A Dissertation, Michael I. Carr

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Plague and the Defeat of Mammalian Innate Immunity: Systematic Genetic Analysis of Yersinia pestis Virulence Factors: A Dissertation, Samantha G. Palace

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A Walk on the Fine Line Between Reward and Risk: AAV-IFNβ Gene Therapy for Glioblastoma: A Dissertation, Dwijit Guhasarkar

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Predictors of Post-injury Mortality in Elderly Patients with Trauma: A Master's Thesis, Charles M. Psoinos

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Structural Mechanisms of the Sliding Clamp and Sliding Clamp Loader: Insights into Disease and Function: A Dissertation, Caroline M. Duffy

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The Drosophila Homolog of the Intellectual Disability Gene ACSL4 Acts in Glia to Regulate Morphology and Neuronal Activity: A Dissertation, Caitlin M. Quigley

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Memory CD8+ T Cell Function during Mycobacterium Tuberculosis Infection: A Dissertation, Stephen M. Carpenter

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A Role for TNMD in Adipocyte Differentiation and Adipose Tissue Function: A Dissertation, Ozlem Senol-Cosar

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The SMURF2-YY1-C-MYC Axis in the Germinal Center Reaction and Diffuse Large B Cell Lymphoma: A Dissertation, Sally E. Trabucco

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Viruses Implicated in the Initiation of Type 1 Diabetes Affect β Cell Function and Antiviral Innate Immune Responses: A Dissertation, Glen R. Gallagher

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Mechanisms Regulating Early Mesendodermal Differentiation of Human Embryonic Stem Cells: A Dissertation, Jennifer J. VanOudenhove

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Systematic Experimental Determination of Functional Constraints on Proteins and Adaptive Potential of Mutations: A Dissertation, Li Jiang

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Activation and Inhibition of Multiple Inflammasome Pathways by the Yersinia Pestis Type Three Secretion System: A Dissertation, Dmitry Ratner

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Barriers and Facilitators to Deaf Trauma Survivors’ Help-Seeking Behavior: Lessons for Behavioral Clinical Trials Research: A Master’s Thesis, Melissa L. Anderson

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Characterizing the Disorder in Tristetraprolin and its Contribution to Post-Transcriptional Gene Regulation: A Dissertation, Laura M. Deveau

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Understanding the Sequence-Specificity and RNA Target Recognition Properties of the Oocyte Maturation Factor, OMA-1, in Caenorhabditis elegans: A Dissertation, Ebru Kaymak

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Activation of mTORC1 Improves Cone Cell Metabolism and Extends Vision in Retinitis Pigmentosa Mice: A Dissertation, Aditya Venkatesh

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XIST and CoT-1 Repeat RNAs are Integral Components of a Complex Nuclear Scaffold Required to Maintain SAF-A and Modify Chromosome Architecture: A Dissertation, Heather J. Kolpa

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The Identification and Targeting of Partially-Folded Conformations on the Folding Free-Energy Landscapes of ALS-Linked Proteins for Therapeutic Intervention: A Dissertation, Brian C. Mackness

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The Mechanistic Role and Therapeutic Potential of microRNA-122 in Alcoholic Liver Disease: A Dissertation, Abhishek Satishchandran

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Understanding Drug Resistance and Antibody Neutralization Escape in Antivirals: A Dissertation, Kristina L. Prachanronarong

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Frailty and Outcomes in Liver Transplantation: A Dissertation, Natasha H. Dolgin

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Contraceptive Utilization and Downstream Feto-Maternal Outcomes for Women with Substance Use Disorders: A Dissertation, Gillian J. Griffith

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The Impact of mTORC2 Signaling on the Initiation and Progression of KRAS-Driven Pancreatic Neoplasias: A Dissertation, David R. Driscoll

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A Novel SMC-Like Protein Modulates C. Elegans Condensin Functions: A Dissertation, Lucy F. Chao

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A Role for the Lipid Droplet Protein HIG2 in Promoting Lipid Deposition in Liver and Adipose Tissue: A Dissertation, Marina T. DiStefano

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Conceptualizing, Understanding, and Assessing Research Literacy in a Diverse Population: A Dissertation, Lauren R. Powell

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Molecular Mechanisms of Assembly and Long-term Maintenance of Neuronal Architecture: A Dissertation, Cassandra R. Blanchette

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Synapse Development: Ribonucleoprotein Transport from the Nucleus to the Synapse: A Dissertation, Vahbiz Jokhi

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Cytosolic and Endosomal DNA-Sensing Pathways Differentially Regulate Inflammatory Arthritis, Autoantibody Production, and Bone Remodeling: A Dissertation, Rebecca A. Baum

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Identification and Characterization of MicroRNA Modulators in Caenorhabditis Elegans: A Dissertation, Zhiji Ren

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Eosinophils as Drivers of the IL-23/IL-17 Axis: Implications for Acute Aspergillosis and Allergic Asthma: A Dissertation, Evelyn V. Santos Guerra

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Characterization of Higher-order Chromatin Structure in Bone Differentiation and Breast Cancer: A Dissertation, Ahmet Rasim Barutcu

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Computational Approaches for the Analysis of Chromosome Conformation Capture Data and Their Application to Study Long-Range Gene Regulation: A Dissertation, Bryan R. Lajoie

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Investigating the Architecture and Vesicle Tethering Function of the Yeast Exocyst Complex: A Dissertation, Margaret R. Heider

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Developing an Adeno-Associated Viral Vector (AAV) Toolbox for CNS Gene Therapy: A Dissertation, Sourav Roy Choudhury

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Single Molecule Visualization of the DEAH-Box ARPase Prp22 Interacting with the Spliceosome: A Dissertation, Eric G. Anderson

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Function of the β4 Integrin in Cancer Stem Cells and Tumor Formation in Breast Cancer: A Masters Thesis, Huayan Sun

Publications from 2015

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The Exocyst Subunit Sec6 Interacts with Assembled Exocytic Snare Complexes: A Dissertation, Michelle L. Dubuke

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Systematic Dissection of Roles for Chromatin Regulators in Dynamics of Transcriptional Response to Stress in Yeast: A Dissertation, Hsiuyi V. Chen

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Functional Characterization of Novel PFN1 Mutations Causative for Familial Amyotrophic Lateral Sclerosis: A Dissertation, Chi-Hong Wu

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Hepatitis C Virus: Structural Insights into Protease Inhibitor Efficacy and Drug Resistance: A Dissertation, Djade I. Soumana

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Small RNA Regulation of the Innate Immune Response: A Role for Dicer in the Control of Viral Production and Sensing of Nucleic Acids: A Dissertation, Ryan J. Nistler

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Single-Molecule Imaging Reveals that Argonaute Re-Shapes the Properties of its Nucleic Acid Guides: A Dissertation, William E. Salomon

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Gene Therapy for Amyotrophic Lateral Sclerosis: An AAV Delivered Artifical MicroRNA Against Human SOD1 Increases Survival and Delays Disease Progression of the SOD1G93A Mouse Model: A Dissertation, Lorelei I. Stoica

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Gender Differences in Choice of Procedure and Case Fatality Rate for Elderly Patients with Acute Cholecystitis: A Masters Thesis, Courtney E. Collins

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Diet Quality and Evening Snacking in Relation to Sleep Duration and Quality among Women with Young Children: A Dissertation, Rui Sherry Xiao

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RNA Exosome & Chromatin: The Yin & Yang of Transcription: A Dissertation, Mayuri Rege

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The Epithelial Transmembrane Protein PERP Is Required for Inflammatory Responses to S. typhimurium Infection: A Dissertation, Kelly N. Hallstrom

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Roles of Protein Arginine Methyltransferase 7 and Jumonji Domain-Containing Protein 6 in Adipocyte Differentiation: A Dissertation, Yu-Jie Hu

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Age-related Changes in the Neuronal Architecture of Caenorhabditis Elegans: A Dissertation, Anagha Khandekar

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Optimizing RNA Library Preparation to Redefine the Translational Status of 80S Monosomes: A Dissertation, Erin E. Heyer

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Insights into Melanocyte Regeneration and Melanoma Initiation Using the Zebrafish Model System: A Dissertation, Sharanya Iyengar

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The Role of VTA Gabaergic Nicotinic Acetylcholine Receptors Containing the α4 Subunit in Nicotine Dependence: A Dissertation, Jennifer Ngolab

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Regulation of Metabolism by Hepatic OXPHOS: A Dissertation, Thomas E. Akie

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Unveiling Molecular Mechanisms of piRNA Pathway from Small Signals in Big Data: A Dissertation, Wei Wang

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Diet-responsive Gene Networks Rewire Metabolism in the Nematode Caenorhabditis elegans to Provide Robustness against Vitamin B12 Deficiency: A Dissertation, Emma Watson

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Structural Variation Discovery and Genotyping from Whole Genome Sequencing: Methodology and Applications: A Dissertation, Jiali Zhuang

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ATP-Dependent Heterochromatin Remodeling: A Dissertation, Benjamin J. Manning

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Pushing The Boundaries of Bioluminescence Using Synthetic Luciferins: A Dissertation, David M. Mofford

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Transcriptional Regulation of the Drosophila Peptidoglycan Sensor PGRP-LC by the Steroid Hormone Ecdysone: A Masters Thesis, Mei Tong

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Exploring the Role of FUS Mutants from Stress Granule Incorporation to Nucleopathy in Amyotrophic Lateral Sclerosis: A Dissertation, Hae Kyung Ko

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The Shape of Silence: The Solution-State Conformation of Sir Heterochromatin: A Dissertation, Sarah G. Swygert

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Investigating the Effects of Mutant FUS on Stress Response in Amyotrophic Lateral Sclerosis: A Thesis, Laura J. Kaushansky

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Function and Regulation of the Tip60-p400 Complex in Embryonic Stem Cells: A Dissertation, Poshen B. Chen

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The Influence of the Insulin-Like Gene Family and Diet-Drug Interactions on Caenorhabditis elegans Physiology: A Dissertation, Ashlyn D. Ritter

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Exploring New Strategies to Overcome Resistance in Glioblastoma Multiforme: A Dissertation, Yulian P. Ellis

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A Gene-Centered Method For Mapping 3’UTR-RBP Interactions: A Dissertation, Alex M. Tamburino

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MicroRNAs Protect the Robustness of Distal Tip Cell Migrations from Temperature Changes in Caenorhabditis elegans: A Dissertation, Samantha L. Burke

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Attention Deficit/Hyperactivity Disorder, Screen Time, Physical Activity, and Diet Quality: A Dissertation, Carol Curtin

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Using Experimental and Computational Strategies to Understand the Biogenesis of microRNAs and piRNAs: A Dissertation, Bo W. Han

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The Role of Signal 3 Cytokine Timing in CD8 T Cell Activation: A Dissertation, Stina L. Urban

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Jun Kinases in Hematopoiesis, and Vascular Development and Function: A Dissertation, Kasmir Ramo

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The Role of Medial Habenula-Interpeduncular Nucleus Pathway in Anxiety: A Dissertation, Xueyan Pang

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Cell Size Control in the Fission Yeast Schizosaccharomyces pombe: A Dissertation, Daniel L. Keifenheim

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Identifying, Targeting, and Exploiting a Common Misfolded, Toxic Conformation of SOD1 in ALS: A Dissertation, Melissa S. Rotunno

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Death is Not the End: The Role of Reactive Oxygen Species in Driving Apoptosis-induced Proliferation, Caitlin E. Fogarty

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TAK1-Mediated Post-Translational Modifications Modulate Immune Response: A Dissertation, Li Chen

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Sentinel Lymph Node Biopsy in Elderly Patients with Intermediate Thickness Melanoma: A Masters Thesis, Kate H. Dinh

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Molecular Pathways Mediating Glial Responses during Wallerian Degeneration: A Dissertation, Tsai-Yi Lu

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Cathosis: Cathepsins in Particle-induced Inflammatory Cell Death: A Dissertation, Gregory M. Orlowski

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Language Proficiency, Citizenship, and Food Insecurity among Predominantly Immigrant Caribbean Latinos in Massachusetts: A Masters Thesis, Tariana V. Little

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Role of Protein Kinase Map4k4 in Energy Metabolism: A Dissertation, Laura V. Danai

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Causal Inference Methods for Assessing Neurodevelopment in Children Following Prenatal Exposure to Triptan Medications: A Dissertation, Mollie E. Wood

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Latent Variable Approaches for Understanding Heterogeneity in Depression: A Dissertation, Christine M. Ulbricht

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Hospital Treatment Practices, 30-Day Hospital Readmissions, and Long-Term Prognosis in Patients Hospitalized with Acute Myocardial Infarction: A Dissertation, Han-Yang Chen

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Systematic Analysis of Duplications and Deletions in the Malaria Parasite P. falciparum: A Dissertation, Derrick K. DeConti

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Yeast Upf1 Associates With RibosomesTranslating mRNA Coding Sequences Upstream of Normal Termination Codons: A Dissertation, Ei Ei Min

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Rapid Access to Perinatal Psychiatric Care in Depression (RAPPID): A Master’s Thesis, Nancy Byatt

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Dissecting the Role of a lncRNA and Involvement of Plasmodium Infections in the Innate Immune Response: A Dissertation, Jennie Chan

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Subtle Controllers: MicroRNAs Drive Pancreatic Tumorigenesis and Progression: A Dissertation, Brian J. Quattrochi

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Use of Opioids for Pain Management in Nursing Homes: A Dissertation, Camilla B. Pimentel

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Role and Regulation of Autophagy During Developmental Cell Death in Drosophila Melanogaster: A Dissertation, Kirsten M. Tracy

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Genes Required for Wallerian Degeneration Also Govern Dendrite Degeneration: A Dissertation, Timothy M. Rooney

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A Tale of Two Projects: Basis for Centrosome Amplification after DNA Damage and Practical Assessment of Photodamage in Live-Cell Imaging: A Dissertation, Stephen Douthwright

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Flipping Biological Switches: Solving for Optimal Control: A Dissertation, Joshua TsuKang Chang

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Sensing of Endogenous Nucleic Acids by the Innate Immune System during Viral Infection: A Dissertation, Stefan A. Schattgen

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Predicting Other Cause Mortality Risk for Older Men with Localized Prostate Cancer: A Dissertation, Daniel M. Frendl

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Paternal Effects on Metabolism in Mammals: A Dissertation, Jeremy M. Shea

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A More Accessible Drosophila Genome to Study Fly CNS Development: A Dissertation, Hui-Min Chen

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MicroRNA Regulation of Autophagy during Programmed Cell Death: A Dissertation, Charles J. Nelson

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Function and Regulation of the α6 Integrins in Mammary Epithelial Biology and Breast Cancer: A Dissertation, Cheng Chang

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Endothelial Driven Inflammation in Metabolic Disease: A Dissertation, Anouch Matevossian

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Calcium Dependent Regulatory Mechanism in Wolfram Syndrome: A Dissertation, Simin Lu

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Advancements in the Synthesis and Application of Near-Infrared Imaging Reagents: A Dissertation, Steven M. Pauff

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Autophagy-Independent Role for Beclin 1 in the Regulation of Growth Factor Receptor Signaling: A Dissertation, Rasika Rohatgi

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Astrocyte-Neuron Interactions Regulate Nervous System Assembly and Function: A Dissertation, Allie Muthukumar

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IRF4 Does the Balancing Act: A Dissertation, Ribhu Nayar

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Characterization of Envelope-Specific Antibody Response Elicited by HIV-1 Vaccines: A Dissertation, Yuxin Chen

Publications from 2014

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MIRAGE DNA Transposon Silencing by C. elegans Condensin II Subunit HCP-6: A Masters Thesis, Anna Malinkevich

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Chromatin Regulators and DNA Repair: A Dissertation, Gwendolyn M. Bennett

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Higher-Order Unfolding of Peri/Centric Satellite Heterochromatin is an Early and Consistent Event in Cell Senescence: A Dissertation, Eric C. Swanson

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The Recombination Enhancer Modulates the Conformation of Chr. III in Budding Yeast: A Dissertation, Jon-Matthew Belton

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Characterization of Innate Immune Pathways in DNA Vaccine-Induced, Antigen-Specific Immune Responses: A Dissertation, John J. Suschak III

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rAAV-Mediated Gene Transfer For Study of Pathological Mechanisms and Therapeutic Intervention in Canavan's Disease: A Dissertation, Seemin Seher Ahmed

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GLI-IKBKE Requirement In KRAS-Induced Pancreatic Tumorigenesis: A Dissertation, Mihir S. Rajurkar

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Amphiphilic Degradable Polymer/Hydroxyapatite Composites as Smart Bone Tissue Engineering Scaffolds: A Dissertation, Artem B. Kutikov

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The Three-Dimensional Structure of the Cystic Fibrosis Locus: A Dissertation, Emily M. Smith

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Dissecting cis and trans Determinants of Nucleosome Positioning: A Dissertation, Amanda L. Hughes

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A Population-Based Perspective on Clinically Recognized Venous Thromboembolism: Contemporary Trends in Clinical Epidemiology and Risk Assessment of Recurrent Events: A Dissertation, Wei Huang

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Oncogene Function in Pre-Leukemia Stage of INV(16) Acute Myeloid Leukemia: A Dissertation, Liting Xue

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Role of Mycobacterium Tuberculosis-Induced Necrotic Cell Death of Macrophages in the Pathogenesis of Pulmonary Tuberculosis: A Dissertation, Teresa S. Repasy

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Neural Orchestration of the C. elegans Escape Response: A Dissertation, Christopher M. Clark

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Regulation of CDK1 Activity during the G1/S Transition in S. cerevisiae through Specific Cyclin-Substrate Docking: A Dissertation, Samyabrata Bhaduri

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Small RNAs and Argonautes Provide a Paternal Epigenetic Memory of Germline Gene Expression to Promote Thermotolerant Male Fertility: A Dissertation, Colin C. Conine

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Psychometric Evaluation of Joint-Specific Patient-Reported Outcome Measures Before and After Total Knee Replacement: A Dissertation, Barbara L. Gandek

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A Feedback Loop Couples Musashi-1 Activity to Omega-9 Fatty Acid Biosynthesis: A Dissertation, Carina C. Clingman

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Long-Term Survival and Prognostic Factors in Patients with Acute Decompensated Heart Failure According to Ejection Fraction Findings: A Population-Based Perspective: A Master Thesis, Andrew H. Coles

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Role of Hdac3 in Murine Coronary Vessel Development: A Master's Thesis, Kevin M. Smee

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Comparative Effectiveness of Lithium and Valproate for Suicide Prevention and Associations With Nonsuicide Mortality: A Dissertation, Eric G. Smith

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Mechanistic Analysis of Differential Signal Transduction Mediated by the Insulin Receptor Substrate Proteins IRS-1 and IRS-2: A Dissertation, Justine M. Landis

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Approaches and Considerations Towards a Safe and Effective Adeno-Associated Virus Mediated Therapeutic Intervention for GM1-Gangliosidosis: A Dissertation, Cara M. Weismann

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Hypertensive Acute Decompensated Heart Failure Presentations: On the Decline? : A Master's Thesis, Chad E. Darling

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Impact of COPD on the Mortality and Treatment of Patients Hospitalized with Acute Decompensated Heart Failure (The Worcester Heart Failure Study): A Masters Thesis, Kimberly A. Fisher

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Early Folding Biases in the Folding Free-Energy Surface of βα-Repeat Proteins: A Dissertation, Robert P. Nobrega

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Evolutionary Approaches to the Study of Small Noncoding Regulatory RNA Pathways: A Dissertation, Alfred T. Simkin

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Activity Regulates Neuronal Connectivity and Function in the C. elegans Motor Circuit: A Dissertation, Belinda Barbagallo

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The Cellular Consequences of FUS/TLS Depletion: A Loss of Function Model for Amyotrophic Lateral Sclerosis: A Dissertation, Catherine L. Ward

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Caspase-8 and RIP Kinases Regulate Bacteria-Induced Innate Immune Responses and Cell Death: A Dissertation, Dan Weng

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Clinical and Financial Impact of Hospital Readmissions Following Colorectal Resection: Predictors, Outcomes, and Costs: A Thesis, Rachelle N. Damle

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Differences in Access to Care and Healthcare Utilization Among Sexual Minorities: A Master's Thesis, Tan Phu Pham

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Putting the Pieces Together: Exons and piRNAs: A Dissertation, Christian K. Roy

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Outpatient Emergency Department Utilization: Measurement and Prediction: A Dissertation, Lisa M. Lines

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POS-1 Regulation of Endo-mesoderm Identity in C. elegans: A Dissertation, Ahmed M. Elewa

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EspFU, an Enterohemorrhagic E. Coli Secreted Effector, Hijacks Mammalian Actin Assembly Proteins by Molecular Mimicry and Repetition: A Dissertation, YuShuan (Cindy) Lai

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An Integrated Structural Mechanism for Relief of Autoinhibition and Membrane Targeting in Cytohesin Family Guanine Nucleotide Exchange Factors: A Dissertation, Andrew W. Malaby

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Characterization of Anti-Fungal Inflammasome Responses and the Role of Caspase-8 in Innate Immune Signaling: A Dissertation, Sandhya Ganesan

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Complex Roles of Macrophages in Lipid Metabolism and Metabolic Disease: A Dissertation, Kimberly A. Negrin

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Dissecting the Role of Cytosolic Nucleic Acid Sensors in the Type I Interferon Response to Herpes Simplex Virus-1 and other Ligands: A Dissertation, Mikayla R. Thompson

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Investigating Tumor Suppressors in the DNA Damage Response: Caretakers of the Genome and Biomarkers to Predict Therapeutic Response: A Dissertation, Shawna S. Guillemette

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Depression in Rheumatoid Arthritis and an Estimation of the Bi-directional Association of Depression and Disease Burden: A Dissertation, Alan M. Rathbun

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Regulation of Type II Responses in Lung Fibrosis and Systemic Autoimmunity: A Dissertation, Tia Bumpus Brodeur

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Studies of HLA-DM in Antigen Presentation and CD4+ T Cell Epitope Selection: A Dissertation, Liusong Yin

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Identification of Molecular Determinants that Shift Co- and Post-Translational N-Glycosylation Kinetics in Type I Transmembrane Peptides: A Dissertation, Heidi L. H. Malaby

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CD8+ T Cell and NK Responses to a Novel Dengue Epitope: A Possible Role for KIR3DL1 in Dengue Pathogenesis: A Dissertation, Elizabeth Townsley

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Role of Astrocytes in Sculpting Neuronal Circuits in the Drosophila CNS: A Dissertation, Ozge E. Tasdemir-Yilmaz

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Identification and Characteristics of Factors Regulating Hepatocellular Carcinoma Progression and Metastasis: A Dissertation, Leanne G. Ahronian

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ADHD-200 Patient Characterization and Classification using Resting State Networks: A Dissertation, Suzanne M. Czerniak

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FUS/TLS in Stress Response - Implications for Amyotrophic Lateral Sclerosis: A Dissertation, Reddy Ranjith Kumar Sama

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Cognitive Status and Initiation of Lifestyle Changes Following Acute Coronary Heart Syndrome: A Dissertation, Alexandra M. Hajduk

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Analyses of All Possible Point Mutations within a Protein Reveals Relationships between Function and Experimental Fitness: A Dissertation, Benjamin P. Roscoe

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Characterization of the Visceral Endoderm Components in Early Post-Implantation Mouse Embryo Development: A Dissertation, Tingting Huang

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Molecular Landscape of Induced Reprogramming: A Dissertation, Chao-Shun Yang

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Heterologous Immunity and T Cell Stability During Viral Infections: A Dissertation, Jenny Wun-Yue Che

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Developing Three New Pathophysiologically Based Measures of Nicotine Dependence: A Dissertation, W. W. Sanouri A. Ursprung

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From Neurodegeneration to Infertility and Back - Exploring Functions of Two Genes: ARMC4 and TARDBP: A Dissertation, Wei Cheng

Publications from 2013

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A Role for Neuronal Nicotinic Acetylcholine Receptors in Dopamine-Mediated Behaviors and the Hypnotic Response to Anesthetics: A Dissertation, Lindsey G. Soll

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Understanding Regulation of the Cytoskeleton during Cell Cycle Transitions through Examination of Crosstalk between Homologous Fission Yeast Pathways, Septation Initiation Network and Morphogenesis ORB6 Network: A Dissertation, Sneha Gupta

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Tissue-dependent T Cell Apoptosis and Transcriptional Regulation of Memory CD8+T Cell Differentiation During Viral Infections: A Dissertation, Varun N. Kapoor

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piRNA Biogenesis and Transposon Silencing in Drosophila: A Dissertation, Zhao Zhang

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hox Gene Regulation and Function During Zebrafish Embryogenesis: A Dissertation, Steven E. Weicksel

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A Novel Autophagy Regulatory Mechanism that Functions During Programmed Cell Death: A Dissertation, Tsun-Kai Chang

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Disparate Activation of the Inflammasome by Chitin and Chitosan: A Dissertation, Chelsea L. Bueter

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Human Cytomegalovirus Reprograms the Expression of Host Micro-RNAs whose Target Networks are Required for Viral Replication: A Dissertation, Alexander N. Lagadinos

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HIV-1 and the Nucleolus: A Role for Nucleophosmin/NPM1 in Viral Replication: A Dissertation, Tracy E. Schmidt

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A Novel Role of UAP56 in piRNA Mediated Transposon Silencing: A Dissertation, Fan Zhang

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The Role of Heterologous Immunity in Viral Co-Infections and Neonatal Immunity: A Dissertation, Laurie L. Kenney

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Itk is a Dual Action Regulator of Immunoreceptor Signaling in the Innate and Adaptive Immune System: A Dissertation, John W. Evans III

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Structure-based Targeting of Transcriptional Regulatory Complexes Implicated in Human Disease: A Dissertation, Brendan J. Hilbert

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Morphogenetic Requirements for Embryo Patterning and the Generation of Stem Cell-derived Mice: A Dissertation, Yeonsoo Yoon

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Modulating Influenza and Heparin Binding Viruses’ Pathogenesis with Extrinsic Receptor Decoy Liposomes: A Dissertation, Gabriel L. Hendricks

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On Identifying Signatures of Positive Selection in Human Populations: A Dissertation, Jessica L. Crisci

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Experimental Illumination of Comprehensive Fitness Landscapes: A Dissertation, Ryan T. Hietpas

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A Role for Intraflagellar Transport Proteins in Mitosis: A Dissertation, Alison R. Bright

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Investigating Cancer Molecular Genetics using Genome-wide RNA Interference Screens: A Dissertation, Ryan W. Serra

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Transcriptional and Translational Mechanisms Controlling Circadian Rhythms in Drosophila: A Dissertation, Jinli Ling

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Dynamic Regulation at the Neuronal Plasma Membrane: Novel Endocytic Mechanisms Control Anesthetic-Activated Potassium Channels and Amphetamine-Sensitive Dopamine Transporters: A Dissertation, Luke R. Gabriel

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dSarm/Sarm1 Governs a Conserved Axon Death Program: A Dissertation, Jeannette M. Osterloh

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Investigation of Multiple Concerted Mechanisms Underlying Stimulus-induced G1 Arrest in Yeast: A Dissertation, Patricia A. Pope

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RNA Interference by the Numbers: Explaining Biology Through Enzymology: A Dissertation, Liang Meng Wee

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Structure and Dynamics of Viral Substrate Recognition and Drug Resistance: A Dissertation, Aysegul Ozen

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Expanding the Known DNA-binding Specificity of Homeodomains for Utility in Customizable Sequence-specific Nucleases: A Dissertation, Stephanie W. Chu

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The Study of Two Strategies for Decreasing Mutant Huntingtin: Degradation by Puromycin Sensitive AminoPeptidase and RNA Interference: A Dissertation, Joanna Chaurette

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The Effects of Family and Social Engagement on the Screen Time of Youth with Developmental Disabilities: A Dissertation, Charmaine B. Lo

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The Role and Regulation of Etv2 in Zebrafish Vascular Development: A Dissertation, John C. Moore

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Elucidating the Molecular Mechanism of CYLD-Mediated Necrosis: A Dissertation, David M. Moquin

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Layered Reward Signalling Through Octopamine and Dopamine in Drosophila: A Dissertation, Christopher J. Burke

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The Notch1-c-Myc Pathway Mediates Leukemia-Initiating Cell Activity in Mouse T-ALL Models: A Dissertation, Jessica M. Tesell

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Understanding Neural Networks in Awake Rat by Resting-State Functional MRI: A Dissertation, Zhifeng Liang

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Role of Map4k4 in Skeletal Muscle Differentiation: A Dissertation, Mengxi Wang

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Adjuvant-Specific Serum Cytokine Profiles in the Context of a DNA Prime-Protein Boost HIV-1 Vaccine: A Dissertation, Rachel Buglione-Corbett

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Suppressive Oligodeoxynucleotides Inhibit Cytosolic DNA Sensing Pathways: A Dissertation, John J. Kaminski III

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Application of a Naïve Bayes Classifier to Assign Polyadenylation Sites from 3' End Deep Sequencing Data: A Dissertation, Sarah E. Sheppard

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Genetic Deficiency of CD40 in Mice Exacerbates Metabolic Manifestations of Diet-induced Obesity: A Dissertation, Chang-An Guo

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Nuclear Organization in Breast Cancer: A Dissertation, Jason R. Dobson

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Role of Autophagy in Post-Mitotic Midbody Fate and Function: A Dissertation, Tse-Chun Kuo

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The Role of Ion Channels in Coordinating Neural Circuit Activity in Caenorhabditis elegans: A Dissertation, Jennifer K. Pirri

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Local Macrophage Proliferation in Adipose Tissue Is a Characteristic of Obesity-Associated Inflammation: A Dissertation, Shinya U. Amano

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Role of Inflammation in Diet-Induced Obesity: A Dissertation, Sophia Kogan

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Runx Expression in Normal and Osteoarthritic Cartilage: Possible Functions of Runx Proteins in Chondrocytes: A Dissertation, Kimberly T. LeBlanc

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The Role of Inducible T Cell Kinase (Itk) in the Development of Innate T Cells and in the Formation of Protective Memory Responses: A Dissertation, Amanda L. Prince

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Role of the Cytoplasmic Polyadenylation Element Binding Proteins in Neuron: A Dissertation, Aparna Oruganty

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Regulation of Higher Order Chromatin at GRIN2B and GAD1 Genetic Loci in Human and Mouse Brain: A Dissertation, Rahul Bharadwaj

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Modulators of the Acute Inflammatory Response: A Dissertation, Dipti Karmarkar

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Identification and Analysis of the Domain Required for Trans-Acceleration Kinetics in the Human Glucose Transporter GLUT1: A Dissertation, Sabrina S. Vollers

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Inflammasomes and the Innate Immune Response Against Yersinia Pestis: A Dissertation, Gregory I. Vladimer

Publications from 2012

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An Extra-Embryonic Wnt Signaling Event Controls Gastrulation in Mice: A Dissertation, Giovane G. Tortelote

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Investigating the Roles of NEDD4.2s and Nef in the Release and Replication of HIV-1: A Dissertation, Eric R. Weiss

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Glial Control of Synapse Assembly at the Drosophila Neuromuscular Junction: A Dissertation, Kimberly S. Kerr

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Hepatitis C Virus Non-Structural Protein 3/4A: A Tale of Two Domains: A Dissertation, Cihan Aydin

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Serotonin-Expressing Cells in the Corpus of the Stomach Originate from Bone Marrow: A Master’s Thesis, Brian T. Johnston

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Psychosocial and Behavioral Determinants of Medication Nonadherence Among African Americans with Hypertension: A Dissertation, Yendelela L. Cuffee

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A Novel Communication Mechanism Between the Presynapse and Postsynapse Through Exosomes: A Dissertation, Ceren Korkut

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Sequence and Target Specificity of the C. elegans Cell Fate Specification Factor POS-1: A Dissertation, Brian M. Farley

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Studies on Cellular Host Factors Involved in the HIV-1 Life Cycle: A Dissertation, Anna Kristina Serquiña

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The Role of ITK in the Development of Gamma Delta NKT Cells: A Dissertation, Catherine C. Yin

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Maintaining the Balance: Coordinating Excitation and Inhibition in a Simple Motor Circuit: A Dissertation, Hilary A. Petrash

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Mechanical Activation of Valvular Interstitial Cell Phenotype: A Dissertation, Angela M. Throm Quinlan

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Role of Perivascular and Visceral Adipose Tissues in Murine Models of Obesity and Atherosclerosis: A Dissertation, Timothy P. Fitzgibbons

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Molecular Studies of T Cell Recognition and Cross-Reactivity: A Dissertation, Zu T. Shen

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Gene Expression and Profiling of Human Islet Cell Subtypes: A Master’s Thesis, David M. Blodgett

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Protein Ligand Interactions Probed by NMR: A Dissertation, Jennifer M. Laine

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MicroRNA Markers of Acetaminophen Toxicity: A Master's Thesis, Jeanine Ward

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RNA-Sensing Pattern Recognition Receptors and Their Effects on T-Cell Immune Responses: A Dissertation, Rachel F. Madera

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Understanding Small RNA Formation in Drosophila Melanogaster: A Dissertation, Elif Sarinay Cenik

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Therapeutic Silencing of Mutant Huntingtin by Targeting Single Nucleotide Polymorphisms: A Dissertation, Edith L. Pfister

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Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation, Hugh S. Gannon

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Slow-Cycling Cancer Cells: A Dissertation, Nathan F. Moore

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Innate Signaling Pathways in the Maintenance of Serological Memory: A Dissertation, Forum M. Raval

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Characterization of Drug Resistance in Mycobacterium Tuberculosis via Saturating Mutagenesis of Drug Targets: A Master’s Thesis, Michelle J. Harris

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Eaters of the Dead: How Glial Cells Respond to and Engulf Degenerating Axons in the CNS: A Dissertation, Jennifer S. Ziegenfuss

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A Role for c-Jun Kinase (JNK) Signaling in Glial Engulfment of Degenerating Axons: A Dissertation, Jennifer M. MacDonald

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Transposition Driven Genomic Heterogeneity in the Drosophila Brain: A Dissertation, Paola N. Perrat

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Antagonistic Pleiotropy: The Role of Smurf2 in Cancer and Aging: A Dissertation, Charusheila Ramkumar

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Mechanisms of KRAS-Mediated Pancreatic Tumor Formation and Progression: A Dissertation, Victoria A. Appleman

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Small Molecule Investigation of KCNQ Potassium Channels: A Dissertation, Karen Mruk

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Transcriptional Regulation of the Interleukin-8 Promoter by Multiple Dengue Viral Proteins: A Dissertation, Jacob M. Collins

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Runx1 C-terminal Domains During Hematopoietic Development and Leukemogenesis: A Dissertation, Christopher R. Dowdy

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Chromatin Dynamics in Pluripotency and Differentiation: A Dissertation, Ozlem Yildirim

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The Molecular Mechanisms for Maintenance of Cancer Stem Cells in Chronic Myeloid Leukemia: A Dissertation, Haojian Zhang

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The Role of Adaptor Protein Complex-3 Delta-Mediated HIV-1 Gag Trafficking in HIV-1 Replication: A Dissertation, Adonia Lee Kim

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Inflammation Inhibits Osteoblast-Mediated Bone Formation in Rheumatoid Arthritis and Regulates the Wnt and BMP Signaling Pathways: A Dissertation, Melissa M. Matzelle

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HIV-1 R5 Tropism: Determinants, Macrophages, and Dendritic Cells: A Dissertation, Thomas A. Musich

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Building the Cell's Antenna: Protein Targeting to the Ciliary Membrane: A Dissertation, John A. Follit

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TXNIP is a Mediator of ER Stress-Induced β-Cell Inflammation and Apoptosis: A Dissertation, Christine M. Oslowski

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Catalytic Mechanisms in Sec7 and Vps9 Domain Exchange Factors for Arf and Rab GTPases: A Dissertation, Meng-Tse Lee

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Targeting the Histone Acetyl-Transferase, RTT109, for Novel Anti-Fungal Drug Development: A Dissertation, Jessica Lopes da Rosa-Spiegler

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Genetic Approaches to Study Transcriptional Activation and Tumor Suppression: A Dissertation, Ling Lin

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Molecular Mechanisms of Endocytosis: Trafficking and Functional Requirements for the Transferrin Receptor, Small Interfering RNAs and Dopamine Transporter: A Dissertation, Deanna M. Navaroli

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Incidence, prognosis, and factors associated with cardiac arrest in patients hospitalized with acute coronary syndromes (the GRACE Registry): A master's thesis, David D. McManus

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Getting a Tight Grip on DNA: Optimizing Zinc Fingers for Efficient ZFN-Mediated Gene Editing: A Dissertation, Ankit Gupta

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Lack of CFTR in CD3+ Lymphocytes Leads to Aberrant Cytokine Secretion and Hyper-Inflammatory Adaptive Immune Responses: A Master's Thesis, Christian Mueller

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Contribution of WFS1 to Pancreatic Beta Cell Survival and Adaptive Alterations in WFS1 Deficiency: A Dissertation, Bryan M. O'Sullivan-Murphy

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Origin of White and Brown Adipose Cells From Vascular Endothelium: A Dissertation, Khanh-Van T. Tran

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Gene Therapy for Very Long Chain Acyl-coA Dehydrogenase Deficiency Using Adeno-Associated Virus Vectors: A Dissertation, Allison M. Keeler

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Analysis of Integrin α6β4 Function in Breast Carcinoma: A Dissertation, Kristin D. Gerson

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On the Source of Peptides for Major Histocompatibility Class I Antigen Presentation: A Dissertation, Diego José Farfán Arribas

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The Subtype Specific and Cross-Reactive T Cell Responses to Influenza Viruses in Humans: A Dissertation, Jenny Aurielle B. Babon

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Localization of Insulin Receptor Substrate-2 in Breast Cancer: A Dissertation, Jennifer L. Clark

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A New Murine Model For Enterohemorrhagic Escherichia coli Infection Reveals That Actin Pedestal Formation Facilitates Mucosal Colonization and Lethal Disease: A Dissertation, Emily M. Mallick

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The Role of Heterologous Immunity in Mediating Natural Resistance to Infection in Human Subjects: A Dissertation, Levi B. Watkin

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Dissecting Somatic Cell Reprogramming by MicroRNAs and Small Molecules: A Dissertation, Zhonghan Li

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Characterization of New Factors in the 18S Nonfunctional Ribosomal RNA Decay Pathway in S. cerevisiae: A Dissertation, Christopher N. Merrikh

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A Population-Based Epidemiological Description of Socio-Demographic Characteristics and Predictors of Severity Among Hospitalized 2009 H1N1 Influenza Cases in Massachusetts: A Dissertation, Hilary Placzek

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Primary and Secondary Immune Responses During Sequential West Nile Virus and Japanese Encephalitis Virus Infections: A Dissertation, Derek W. Trobaugh

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Distinct Gene Circuits Control the Differentiation of Innate Versus Adaptive IL-17 Producing T Cells: A Dissertation, Nidhi Malhotra

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Role of Glia in Sculpting Synaptic Connections at the Drosophila Neuromuscular Junction: A Dissertation, Yuly F. Fuentes Medel

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Control of Bovine Papillomavirus E2 Function By Acetylation and the Novel E2 Interacting Protein RINT1: A Dissertation, Edward J. Quinlan

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Studies on the Regulation of Cytoplasmic Polyadenylation Element-Binding Protein: A Dissertation, Chien-Ling Lin

Publications from 2011

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Herbal Marijuana Alternatives Investigation: K2 and Spice: A Masters Thesis, Christopher D. Rosenbaum

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Intestine Homeostasis and the Role of Tumor Suppressor Gene 101 in Drosophila Melanogaster: A Dissertation, Madhurima Chatterjee

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Comparative Effectiveness of Alendronate and Risedronate on the Risk of Non-Vertebral Fractures in Older Women: An Instrumental Variables Approach: A Dissertation, Yong Chen

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Cannabis Use and Bipolar Disorder: Bipolar Disorder Case Identification and Cannabis Use Risk Assessment: A Dissertation, Patrick J. McCabe

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Support of Mitochondrial DNA Replication by Human Rad51: A Dissertation, Jay M. Sage

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Cellular and Molecular Mechanisms Driving Glial Engulfment of Degenerating Axons: A Dissertation, Johnna E. Doherty

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Insights Into ER Translocation Channel Gating. Structural Regulation of the Transition Between the Closed and Open Channel Conformations: A Dissertation, Steven F. Trueman

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Autoregulatory and Paracrine Control of Synaptic and Behavioral Plasticity by Dual Modes of Octopaminergic Signaling: A Dissertation, Alex C. Koon

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Telomere Length Dynamics in Human T Cells: A Dissertation, Joel M. O'Bryan

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Using Light to Observe and Control Cellular Function: Improving Bioluminescence Imaging and Photocontrol of Rho GTPase Activation States: A Dissertation, Katryn R. Harwood

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M.tb Killing by Macrophage Innate Immune Mechanisms: A Dissertation, Michelle L. Hartman

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Neuronal Diversification in the Postembryonic Drosophila Brain: A Dissertation, Suewei Lin

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Early Detection and Treatment of Acute Clinical Decline in Hospitalized Patients: An Observational Study of ICU Transfers and an Assessment of the Effectiveness of a Rapid Response Program: A Dissertation, Tanya Lord

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Treating GM1 Gangliosidosis With Ex Vivo Hematopoietic Stem Cell Gene Therapy Without Using Total Body Irradiation: A Masters Thesis, Michael Whalen

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Intranasal Colonization by Streptococcus Pneumoniae Induces Immunological Protection from Pulmonary and Systemic Infection: A Dissertation, Nang H. Maung

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Role of Protein Flexibility in Function, Resistance Pathways and Substrate Recognition Specificity in HIV-1 Protease: A Dissertation, Seema Mittal

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Two Distinct Modes of Signaling by Vascular Endothelial Growth Factor C Guide Blood and Lymphatic Vessel Patterning in Zebrafish: A Dissertation, Jacques A. Villefranc

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Nuclear Import of Smad: A Dissertation, Xiaochu Chen

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Digital and Analog STAT5 Signaling in Erythropoiesis: A Dissertation, Ermelinda Porpiglia

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Structural Studies of the Anti-HIV Human Protein APOBEC3G Catalytic Domain: A Dissertation, Shivender Shandilya

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Regulation and Function of Neuronal Nicotinic Acetylcholine Receptors in Lung Cancer: A Dissertation, Ma. Reina D. Improgo

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Asymmetric Inheritance and Post-mitotic Fate of Midbodies: A Dissertation, Chun-Ting Chen

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Tyraminergic G Protein-Coupled Receptors Modulate Locomotion and Navigational Behavior In C. Elegans: A Dissertation, Jamie L. Donnelly

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Cooperativity in Mammalian RNA Silencing: A Dissertation, Jennifer A. Broderick

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Use of Multinational Registries to Assess and Compare Outcomes of Patients with an Acute Coronary Syndrome: A Dissertation, Hamza H. Awad

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Biomimetic Synthetic Tissue Scaffolds for Bone Regeneration: A Dissertation, Tera M. Filion Potts

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Global DNA Demethylation During Erythropoiesis: A Dissertation, Jeffrey R. Shearstone

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Chromosome-Biased Binding and Function of C. elegans DRM Complex, and Its Role in Germline Sex-Silencing: A Dissertation, Tomoko M. Tabuchi

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Regulation of Runx Proteins in Human Cancers: A Dissertation, Sandhya Pande

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Dissection of α6β4 Integrin-Dependent Signaling and Breast Carcinoma Invasion: A Dissertation, Xiaoqing Yang

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Nucleic Acid Sensing by the Immune System: Roles For the Receptor For Advanced Glycation End Products (RAGE) and Intracellular Receptor Proteins: A Dissertation, Cherilyn M. Sirois

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Dynamics of Erythropoietic Survival Pathways In Vivo: A Dissertation, Miroslav Koulnis

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Investigation of the C-Terminal Helix of HIV-1 Matrix: A Region Essential for Multiple Functions in the Viral Life Cycle: A Dissertation, Laura A. Brandano

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The Role of PC4 in Oxidative Stress: A Dissertation, Lijian Yu

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Quantitative Analysis of Novel Chemical and shRNA Based Methods to Increase Survival of Motor Neuron Protein Levels, Matthew C. Evans

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Regulation of Humoral Immunity by Pim Kinases: A Dissertation, Kristen N. Willems

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Investigating Age-Dependent Arthropathy in a Circadian Mutant Mouse Model: A Dissertation, Elizabeth A. Yu

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Mechanisms of Substrate Recognition by HCV NS3/4A Protease Provide Insights Into Drug Resistance: A Dissertation, Keith P. Romano

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Inflammation Alters Histone Methylation in the Central Nervous System: Implications for Neuropsychiatric Disease: A Dissertation, Caroline M. Connor

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The Importance of the Centrosomal Localization Sequence of Cyclin E for Promoting Centrosome Duplication: A Dissertation, Joshua J. Nordberg

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A Global Analysis of the Adaptations Required for Sterol Catabolism in Mycobacterium Tuberculosis: A Dissertation, Jennifer E. Griffin

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Conformational Lability in MHC II Proteins: A Dissertation, Corrie A. Painter

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Blocking the Notch Pathway with Gamma-Secretase Inhibitors Enhances Temozolomide Treatment of Gliomas through Therapy-Induced Senescence: A Dissertation, Candace A. Gilbert

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A Tale of Two SNPS: Polymorphism Analysis of Toll-like Receptor (TLR) Adapter Proteins: A Dissertation, Kamalpreet Nagpal

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Identification of a Command Neuron Directing the Expression of Feeding Behavior in Drosophila melanogaster: A Dissertation, Thomas F. Flood

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Critical and Independent Roles of the P/CAF Acetyltransferase in ARF-p53 Signaling: A Dissertation, Ian M. Love

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Roles of Secreted Virulence Factors in Pathogenicity of Haemophilus Influenzae: A Dissertation, Charles V. Rosadini

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Critical Molecular Pathways in Cancer Stem Cells of Chronic Myeloid Leukemia: A Dissertation, Yaoyu Chen

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Insulin Receptor Substrate-2 (IRS-2): A Novel Hypoxia-Responsive Gene in Breast Cancer: A Dissertation, Katerina Mardilovich

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The Role of miR-21 and miR-31 in Cellular Responses Mediated by TGF-β: A Dissertation, Charisa L. Cottonham

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Hsp90-Mediated Maturation of Kinases and Nuclear Steroid Hormone Receptors: A Dissertation, Natalie W. Pursell

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Factors Associated with Ordering and Completion of Laboratory Monitoring Tests for High-Risk Medications in the Ambulatory Setting: A Dissertation, Shira H. Fischer

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Molecular Mechanisms of piRNA Biogenesis and Function in Drosophila: A Dissertation, Chengjian Li

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The Effect of Glycemic Index and Glycemic Load on Glucose Control, Lipid Profiles and Anthropometrics Among Low-Income Latinos With Type 2 Diabetes: A Dissertation, Lauren A. Gellar

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Dissecting Signaling Pathways that Regulate Axonal Guidance Effects of Sonic Hedgehog: A Dissertation, Daorong Guo

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The Function of Innate γδ T Cell Subsets is Molecularly Programmed in the Thymus in Three Stages: A Dissertation, Kavitha Narayan

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Cooperating Events in Core Binding Factor Leukemia Development: A Dissertation, Dmitri Madera

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Molecular and Functional Properties of Transmitted HIV-1 Envelope Variants: A Dissertation, Michael G. Kishko

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Role of the Yeast Ste20 Protein Kinase Ortholog Map4k4 in Adipose Tissue Function: A Dissertation, Kalyani V. P. Guntur

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Neuronal Nicotinic Acetylcholine Receptors: Molecular Targets for Alcoholism and Ethanol Reward: A Dissertation, Linzy M. Hendrickson

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Improved Methods of Sepsis Case Identification and the Effects of Treatment with Low Dose Steroids: A Dissertation, Huifang Zhao

Publications from 2010

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Clinical Course of Bipolar Disorder During the Menopausal Transition: Comparison with Reproductive Age and Post Menopausal Women: A Master's Thesis, Wendy K. Marsh

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Host Cell Attachment by Lyme Disease and Relapsing Fever Spirochetes: A Dissertation, Vivian M. Benoit

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Immunity, Pathogenesis, and Prevention of Poxvirus Infections: A Dissertation, Mina O. Seedhom

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The C Terminus of Activation Induced Cytidine Deaminase (AID) Recruits Proteins Important for Class Switch Recombination to the IG Locus: A Dissertation, Sanjay Ranjit

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Axon Death Prevented: Wlds and Other Neuroprotective Molecules: A Dissertation, Michelle A. Avery

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CD8+ T Cell Serotype-Cross-Reactivity is a Predominant Feature of Dengue Virus Infections in Humans: A Dissertation, Heather L. Friberg-Robertson

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MRI Contrast Agent Studies of Compartmental Differentiation, Dose-Dependence, and Tumor Characterization in the Brain: A Dissertation, Mohammed S. Shazeeb

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A Mindfulness-Based Intervention for Treatment of Anxiety in ICD Patients: Feasibility and Baseline Findings: A Dissertation, Elena Salmoirago Blotcher

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Converging Pathways in the Regulation of Longevity and Metabolism in Caenorhabditis Elegans: A Dissertation, Sri Devi Narasimhan

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Drosophila piRNA Function in Genome Maintenance, Telomere Protection and Genome Evolution: A Dissertation, Jaspreet S. Khurana

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Regulation of Cellular and HIV-1 Gene Expression by Positive Transcription Elongation Factor B: A Dissertation, Siobhan O'Brien

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Beyond Toll-Like Receptor 9: Interactions Between Plasmacytoid Dendritic Cells and Aspergillus Fumigatus: A Dissertation, Zaida G. Ramirez-Ortiz

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Acute Modulation of Endothelial Cell Glucose Transport: A Dissertation, Anthony J. Cura

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Generating Nucleosomal Asymmetry in Saccharomyces cerevisiae: A Masters Thesis, Yuanyuan Chen

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Energy Metabolism and the Induction of the Unfolded Protein Response: A Dissertation, Alison M. Burkart

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A Glia-Mediated Feedback Mechanism for the Termination of Drosophila Visual Response: A Dissertation, Peiyi Guo

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Mitochondrial Dysfunction and AKT Isoform-Specific Regulation in 3T3-L1 Adipocytes: A Dissertation, Xiarong Shi

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Regulation of Early T Cell Activation by TNF Superfamily Members TNF and FASL: A Dissertation, Bhavana Priyadharshini

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Elucidating the Transcriptional Network Underlying Expression of a Neuronal Nicotinic Receptor Gene: A Dissertation, Michael D. Scofield

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Magnetic Resonance Imaging of Neural and Pulmonary Vascular Function: A Dissertation, Ronn P. Walvick

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Structural and Functional Studies of Proteins Involved in Antigen Processing: A Dissertation, Tina T. Nguyen

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Mechanical Flow Restoration in Acute Ischemic Stroke: A Model System of Cerebrovascular Occlusion: A Dissertation, Juyu Chueh

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Dissecting the Role of Innate Pattern Recognition Receptors and Interferon Regulatory Factor-5 in the Immune Response to Human Metapneumovirus and other Pathogens: A Dissertation, Zhaozhao Jiang

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Elucidation of the Multi-Faceted Roles of the SIN (Septation Initiation Network); Understanding How the SIN Promotes Cytokinesis and Inhibits Interphase Growth in the Fission Yeast Schizosaccharomyces pombe: A Dissertation, Samriddha Ray