The Program in Biochemistry & Molecular Pharmacology is an academic program of the Graduate School of Biomedical Sciences (GSBS) at the University of Massachusetts Medical School. The program offers graduate study and research focused in the areas of molecular, cellular and regulatory biochemistry; molecular biophysics; chemical biology; and structural biology. This collection showcases publications and presentations authored by students in this program.

Attention GSBS Biochemistry & Molecular Pharmacology students: To submit your publications, go to GSBS Student Publications and click on Submit Research in the left sidebar. You’ll need to log in or create a free account. If you have the article's PubMed ID, submission is very easy. Enter the PubMed ID and information from PubMed will be used to populate the submission form. Questions? Contact Lisa Palmer.

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Publications from 1989

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Differentiation of human hematopoietic cells increases expression of a gene transferred by a retroviral vector, Christie A. Holland, Sunil Chada, Jocyndra A. Wright, Constance Whitney, Kenichi Harigaya, Joel S. Greenberger, and Peter E. Newburger

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Serum form of the rat insulin-like growth factor II/mannose 6-phosphate receptor is truncated in the carboxyl-terminal domain, Richard G. MacDonald, Mark A. Tepper, Kevin B. Clairmont, Susan B. Perregaux, and Michael P. Czech

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Regulation of substance P receptor affinity by guanine nucleotide-binding proteins, Susan G. MacDonald and Norman D. Boyd

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Antiviral effect of lymphokine-activated killer cells: chemotaxis and homing to sites of virus infection, Robert J. Natuk, Jack F. Bukowski, Jeffery O. Brubaker, and Raymond M. Welsh

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Arachidonic acid and other fatty acids directly activate potassium channels in smooth muscle cells, Richard W. Ordway, John V. Walsh, and Joshua J. Singer

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Altered binding of human histone gene transcription factors during the shutdown of proliferation and onset of differentiation in HL-60 cells, Gary S. Stein, Jane B. Lian, Janet L. Stein, Robert C. Briggs, Victoria Shalhoub, Kenneth Lynn Wright, Urs Pauli, and Andre J. Van Wijnen

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Modifications in molecular mechanisms associated with control of cell cycle regulated human histone gene expression during differentiation, Gary S. Stein, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Kenneth Lynn Wright, and Urs Pauli

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Carbonyldiphosphonate, a selective inhibitor of mammalian DNA polymerase delta, Robert Vincent Talanian, Neal C. Brown, Charles E. McKenna, Ting Gao Ye, Jeffrey N. Levy, and George E. Wright

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Soluble CD8 during T cell activation, Blake E. Tomkinson, Michael C. Brown, Stephen H. Ip, Susan Carrabis, and John L. Sullivan

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Characterization of the T cell-mediated cellular cytotoxicity during acute infectious mononucleosis, Blake E. Tomkinson, Richard T. Maziarz, and John L. Sullivan

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Human H4 histone gene transcription requires the proliferation-specific nuclear factor HiNF-D. Auxiliary roles for HiNF-C (Sp1-like) and HiNF-A (high mobility group-like), Andre J. Van Wijnen, Kenneth Lynn Wright, Jane B. Lian, Janet L. Stein, and Gary S. Stein

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Virus-induced polyclonal cytotoxic T lymphocyte stimulation, Hyekyung Yang, Patricia L. Dundon, Sharon R. Nahill, and Raymond M. Welsh

Publications from 1988

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Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes, Joaquin Arino, Chee-Wai Woon, David L. Brautigan, Thomas B. Miller Jr., and Gary L. Johnson

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Antiviral effect of lymphokine-activated killer cells: characterization of effector cells mediating prophylaxis, Jack F. Bukowski, Hyekyung Yang, and Raymond M. Welsh

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The human H1 histone gene FNC16 is functionally expressed in proliferating HeLa S3 cells and is down-regulated during terminal differentiation in HL60 cells, David G. Collart, Kenneth Lynn Wright, Andre J. Van Wijnen, Anna L. Ramsey-Ewing, Jane B. Lian, Janet L. Stein, and Gary S. Stein

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A highly phosphorylated subpopulation of insulin-like growth factor II/mannose 6-phosphate receptors is concentrated in a clathrin-enriched plasma membrane fraction, Silvia Corvera, Kimberly L. Folander, Kevin B. Clairmont, and Michael P. Czech

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Characterization of antigen processing and presentation by resting B lymphocytes, Edmund J. Gosselin, Hans-Peter Tony, and David C. Parker

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The effects of mutations in the ant promoter of phage P22 depend on context, Dolores Grana, Thomas James Gardella, and Miriam M. Susskind

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The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences, Edward H. Kislauskis, Bryant Paul Bullock, Sandra Marie McNeil, and Paul R. Dobner

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Blastogenesis of large granular lymphocytes in nonlymphoid organs, Kim W. McIntyre, Robert J. Natuk, Christine A. Biron, Kenneth Kase, Joel S. Greenberger, and Raymond M. Welsh

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Isolation and analysis of murine serum amyloid P component cDNA clones, John E. Mole, Brian L. Beaulieu, Carolyn A. Geheran, James A. Carnazza, and Jacqueline K. Anderson

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Determinants of mRNA stability in Dictyostelium discoideum amoebae: differences in poly(A) tail length, ribosome loading, and mRNA size cannot account for the heterogeneity of mRNA decay rates, Robert A. Shapiro, David Herrick, Richard E. Manrow, Dmitry B. Blinder, and Allan Jacobson

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Characterization of the microtubule-activated ATPase of brain cytoplasmic dynein (MAP 1C), Howard S. Shpetner, Bryce Mark Paschal, and Richard B. Vallee

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Genetic analysis of the 9.5-kilobase virulence plasmid of Yersinia pestis, Olanrewaju A. Sodeinde and Jon D. Goguen

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Plasminogen activator/coagulase gene of Yersinia pestis is responsible for degradation of plasmid-encoded outer membrane proteins, Olanrewaju A. Sodeinde, Allen K. Sample, Robert R. Brubaker, and Jon D. Goguen

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Proteolytic cleavage of Ii to p25, Lawrence James Thomas, Quoc V. Nguyen, William L. Elliot, and Robert E. Humphreys

Publications from 1987

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Natural killer cells are not required for interferon-mediated prophylaxis against vaccinia or murine cytomegalovirus infections, Jack F. Bukowski, Kim W. McIntyre, Hyekyung Yang, and Raymond M. Welsh

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Molecular analysis of synapsin I, a candidate gene for Rett syndrome, Louis J. DeGennaro, Cheryl A. McCaffery, Cordula U. Kirchgessner, Teresa L. Yang-Feng, and Uta Francke

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An hypothesis on the binding of an amphipathic, alpha helical sequence in Ii to the desetope of class II antigens, William L. Elliot, Christopher J. Stille, Lawrence James Thomas, and Robert E. Humphreys

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A rat histone H4 gene closely associated with the testis-specific H1t gene, Sidney R. Grimes, Paul Weisz-Carrington, Henry A. Daum, John M. Smith, Linda G. Green, Kenneth Lynn Wright, Gary S. Stein, and Janet L. Stein

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Identification of an enhancer-like element upstream from a cell cycle dependent human H4 histone gene, Sherron R. Helms, Andre J. Van Wijnen, Paul E. Kroeger, A. Shiels, C. Stewart, J. Hirshman, Janet L. Stein, and Gary S. Stein

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Mutations in an upstream regulatory sequence that increase expression of the bacteriophage T4 lysozyme gene, Jeffrey A. Knight, Larry W. Hardy, Dale Rennell, David Herrick, and Anthony R. Poteete

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Regulation of glycogen metabolism in primary cultures of rat hepatocytes. Restoration of acute effects of glucose in cells from diabetic rats involves protein synthesis, Thomas B. Miller, Alice K. Garnache, John Cruz, and Charles D. Wolleben

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MAP 1C is a microtubule-activated ATPase which translocates microtubules in vitro and has dynein-like properties, Bryce Mark Paschal, Howard S. Shpetner, and Richard B. Vallee

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Activated lymphocytes during acute Epstein-Barr virus infection, Blake E. Tomkinson, David K. Wagner, David L. Nelson, and John L. Sullivan

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Use of adult rat cardiomyocytes to study cardiac glycogen metabolism, Charles Daniel Wolleben, Steven R. Jaspers, and Thomas B. Miller

Publications from 1986

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Enhanced susceptibility to cytotoxic T lymphocytes of target cells isolated from virus-infected or interferon-treated mice, Jack F. Bukowski and Raymond M. Welsh

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The role of natural killer cells and interferon in resistance to acute infection of mice with herpes simplex virus type 1, Jack F. Bukowski and Raymond M. Welsh

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Differences in sequences encoding the carboxyl-terminal domain of the epidermal growth factor receptor correlate with differences in the disease potential of viral erbB genes, Daniel C. Gamett, Sharon Elizabeth Tracy, and Harriet L. Robinson

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Cell cycle-dependent expression of a stable episomal human histone gene in a mouse cell, Linda G. Green, I. Schlaffer, Kenneth Lynn Wright, M. L. Moreno, D. Berand, Gordon L. Hager, Janet L. Stein, and Gary S. Stein

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Direct evidence for ATP modulation of sugar transport in human erythrocyte ghosts, Daniel N. Hebert and Anthony Carruthers

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Accumulation of natural killer and cytotoxic T large granular lymphocytes in the liver during virus infection, Kim W. McIntyre and Raymond M. Welsh

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Regulation of glycogen metabolism in primary cultures of rat hepatocytes. Restoration of acute effects of insulin and glucose in cells from diabetic rats, Thomas B. Miller, Alice K. Garnache, John Cruz, R. Kirk McPherson, and Charles D. Wolleben

Publications from 1985

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Adoptive transfer studies demonstrating the antiviral effect of natural killer cells in vivo, Jack F. Bukowski, John F. Warner, Gunther Dennert, and Raymond M. Welsh

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Inability of interferon to protect virus-infected cells against lysis by natural killer (NK) cells correlates with NK cell-mediated antiviral effects in vivo, Jack F. Bukowski and Raymond M. Welsh

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Interferon enhances the susceptibility of virus-infected fibroblasts to cytotoxic T cells, Jack F. Bukowski and Raymond M. Welsh

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Functional association of class II antigens with cell surface binding of Epstein-Barr virus, Patricia S. Reisert, Robert Christopher Spiro, Phyllis L. Townsend, Sarah A. Stanford, Takeshi Sairenji, and Robert E. Humphreys

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Phage P22 lysis genes: nucleotide sequences and functional relationships with T4 and lambda genes, Dale Rennell and Anthony R. Poteete

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Immunologic identification of a glycogen synthase 93,000-dalton subunit from rat heart and liver, Jill Rulfs, Charles Daniel Wolleben, Thomas B. Miller, and Gary L. Johnson

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Inhibition of Epstein-Barr virus (EBV) release from the P3HR-1 Burkitt's lymphoma cell line by a monoclonal antibody against a 200,000 dalton EBV membrane antigen, Takeshi Sairenji, Patricia S. Reisert, Robert Christopher Spiro, Timothy Connolly, and Robert E. Humphreys

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Epstein-Barr virus infections in hairy cell leukemia patients in the presence of complement-dependent neutralizing antibody, Takeshi Sairenji, John L. Sullivan, Kiyoshi Sakamoto, Robert Christopher Spiro, Isao Katayama, and Robert E. Humphreys

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Kinetics of Ii synthesis, processing, and turnover in n-butyrate-treated Burkitt's lymphoma cell lines which express or do not express class II antigens and in hairy leukemic cells, Robert C. Spiro, Takeshi Sairenji, and Robert E. Humphreys

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Induction of angiosarcoma by a c-erbB transducing virus, Sharon Elizabeth Tracy, Bruce A. Woda, and Harriet L. Robinson

Publications from 1984

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Pathogenesis of murine cytomegalovirus infection in natural killer cell-depleted mice, Jack F. Bukowski, Bruce A. Woda, and Raymond M. Welsh

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Characterization of Epstein-Barr virus infection of hairy cell leukemia patients, Takeshi Sairenji, Mary Ann Lane, Patricia S. Reisert, Robert Christopher Spiro, Michael E. Henry, Kiyoshi Sakamoto, and Robert E. Humphreys

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Differential effect of TPA and n-butyrate on induction of Ii and EBV antigens in the P3HR-1 lymphoblastoid cell line, Takeshi Sairenji, Robert Christopher Spiro, and Robert E. Humphreys

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Enhanced Ii expression after n-butyrate treatment of a P3HR-1 Burkitt's lymphoma subline which does not express HLA-D, Robert Christopher Spiro, Takeshi Sairenji, and Robert E. Humphreys

Publications from 1983

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Elevated natural killer cell-mediated cytotoxicity, plasma interferon, and tumor cell rejection in mice persistently infected with lymphocytic choriomeningitis virus, Jack F. Bukowski, Christine A. Biron, and Raymond M. Welsh

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Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo, Jack F. Bukowski, Bruce A. Woda, Sonoku Habu, Ko Okumura, and Raymond M. Welsh

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Restrictions upon Epstein-Barr virus infection of the leukemic cell are demonstrated in patients with hairy cell leukemia, Takeshi Sairenji, Patricia S. Reisert, Robert Christopher Spiro, Carel Mulder, and Robert E. Humphreys

Publications from 1982

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Construction of cloned libraries from RNA of human fetal tissues, David M. Kurnit, Bruce Martin Wentworth, L. De Long, and Lydia Villa-Komarof

Publications from 1981

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A hypersensitivity of glycogen phosphorylase activation in hearts of diabetic rats, Thomas B. Miller, M Praderio, Charles Daniel Wolleben, and J Bullman