The Program in Biochemistry & Molecular Pharmacology is an academic program of the Graduate School of Biomedical Sciences (GSBS) at the University of Massachusetts Medical School. The program offers graduate study and research focused in the areas of molecular, cellular and regulatory biochemistry; molecular biophysics; chemical biology; and structural biology. This collection showcases publications and presentations authored by students in this program.

Attention GSBS Biochemistry & Molecular Pharmacology students: To submit your publications, go to GSBS Student Publications and click on Submit Research in the left sidebar. You’ll need to log in or create a free account. If you have the article's PubMed ID, submission is very easy. Enter the PubMed ID and information from PubMed will be used to populate the submission form. Questions? Contact Lisa Palmer.

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Publications from 2002

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DNA microarrays in prostate cancer, Shuk-Mei Ho and Kin-Mang Lau

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Cytokinesis: myosin spots the ring, Ming-Chin Hou and Dannel McCollum

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Mob2p interacts with the protein kinase Orb6p to promote coordination of cell polarity with cell cycle progression, Ming-Chin Hou, David J. Wiley, Fulvia Verde, and Dannel McCollum

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N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses, Yi-Shuian Huang, Mi-Young Jung, Madathia Sarkissian, and Joel D. Richter

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DOC-2/DAB2 is the binding partner of myosin VI, Akira Inoue, Osamu Sato, Kazuaki Homma, and Mitsuo Ikebe

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Integrated channel plasticity contributes to alcohol tolerance in neurohypophysial terminals, Thomas K. Knott, Alejandro M. Dopico, Govindan Dayanithi, Jose R. Lemos, and Steven N. Treistman

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Novel functional interactions between Trk kinase and p75 neurotrophin receptor in neuroblastoma cells, Mahesh B. Lachyankar, Peter J. Condon, Marie-Claire Daou, Asit K. De, John B. Levine, Axel Obermeier, and Alonzo H. Ross

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Activation of the bone-related Runx2/Cbfa1 promoter in mesenchymal condensations and developing chondrocytes of the axial skeleton, Christopher J. Lengner, Hicham Drissi, Je-Yong Choi, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian

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Point mutants of EHEC intimin that diminish Tir recognition and actin pedestal formation highlight a putative Tir binding pocket, Hui Liu, Padhma Radhakrishnan, Loranne Magoun, Moses Prabu-Jeyabalan, Kenneth Geno Campellone, Pamela Joyce Savage, Feng He, Celia A. Schiffer, and John M. Leong

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The absence of Itk inhibits positive selection without changing lineage commitment, Julie Ann Lucas, Luana O. Atherly, and Leslie J. Berg

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Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility, Mai X. Luong, Caroline M. J. van der Meijden, DongXia Xing, RuthAnn M. Hesselton, Edwin S. Monuki, Stephen N. Jones, Jane B. Lian, Janet L. Stein, Gary S. Stein, Ellis J. Neufeld, and Andre J. Van Wijnen

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Calculating the potential of C2 domains for membrane binding, Eric Lee Merithew and David G. Lambright

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Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase, Andrew Todd Miller and Leslie J. Berg

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New insights into the regulation and functions of Tec family tyrosine kinases in the immune system, Andrew Todd Miller and Leslie J. Berg

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Nitric oxide-mediated inhibition of Hdm2-p53 binding, Christopher M. Schonhoff, Marie-Claire Daou, Stephen N. Jones, Celia A. Schiffer, and Alonzo H. Ross

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Meis family proteins are required for hindbrain development in the zebrafish, Choe Seong-Kyu, Nikolaos Vlachakis, and Charles G. Sagerstrom

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Generation of recombinant vaccinia viruses expressing Puumala virus proteins and use in isolating cytotoxic T cells specific for Puumala virus, Masanori Terajima, Heather Lin Van Epps, Dexin Li, Anita M. Leporati, Sarah E. Juhlin, Jukka Mustonen, Antti Vaheri, and Francis A. Ennis

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Long-lived memory T lymphocyte responses after hantavirus infection, Heather Lin Van Epps, Masanori Terajima, Jukka Mustonen, T. Petteri Arstila, Elizabeth Ann Corey, Antti Vaheri, and Francis A. Ennis

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Synthesis of pCpCpA-3'-NH-phenylalanine as a ribosomal substrate, Biliang Zhang, Lei Zhang, Lele Sun, and Zhiyong Cui

Publications from 2001

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The Snail protein family regulates neuroblast expression of inscuteable and string, genes involved in asymmetry and cell division in Drosophila, Shovon Imtiaz Ashraf and Y. Tony Ip

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Differential regulation of the two principal Runx2/Cbfa1 n-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype, Chaitali Banerjee, Amjad Javed, Je-Yong Choi, Jack Green, Vicki Rosen, Andre J. Van Wijnen, Janet L. Stein, Jane B. Lian, and Gary S. Stein

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Absence of Dbp2p alters both nonsense-mediated mRNA decay and rRNA processing, Andrew T. Bond, David A. Mangus, Feng He, and Allan Jacobson

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Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities, Rita Bortell, Joel Moss, Robert C. McKenna, Mark R. Rigby, Dena Niedzwiecki, Linda A. Stevens, Walter A. Patton, John P. Mordes, Dale L. Greiner, and Aldo A. Rossini

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Levels of Art2+ cells but not soluble Art2 protein correlate with expression of autoimmune diabetes in the BB rat, Rita Bortell, Debra J. Waite, Barbara J. Whalen, Derrick James Todd, Jean H. Leif, Elena Lesma, Joel Moss, John P. Mordes, Aldo A. Rossini, and Dale L. Greiner

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Cell-cycle arrest in TrkA-expressing NIH3T3 cells involves nitric oxide synthase, Dylan A. Bulseco, Wojciech Poluha, Christopher M. Schonhoff, Marie-Claire Daou, Peter J. Condon, and Alonzo H. Ross

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xid mice reveal the interplay of homeostasis and Bruton's tyrosine kinase-mediated selection at multiple stages of B cell development, Michael P. Cancro, Alex P. Sah, Sherri L. Levy, David M. Allman, Madelyn R. Schmidt, and Robert T. Woodland

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Injection molding of chondrocyte/alginate constructs in the shape of facial implants, Sophia C. N. Chang, Jon A. Rowley, Geoffrey Tobias, Nicholas G. Genes, Amit K. Roy, David J. Mooney, Charles A. Vacanti, and Lawrence J. Bonassar

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Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung, Hong D. Chen, Armando E. Fraire, Isabelle Joris, Michael A. Brehm, Raymond M. Welsh, and Liisa K. Selin

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HIV-1 Tat protein interacts with mammalian capping enzyme and stimulates capping of TAR RNA, Ya-Lin Chiu, Elizabeth Coronel, C. Kiong Ho, Stewart Shuman, and Tariq M. Rana

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Efficient repair of large DNA loops in Saccharomyces cerevisiae, Stephanie E. Corrette-Bennett, Natasha L. Mohlman, Zulma Rosado, Juan J. Miret, Patricia M. Hess, Breck Olland Parker, and Robert S. Lahue

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Multivalent endosome targeting by homodimeric EEA1, John J. Dumas, Eric Lee Merithew, Eathiraj Sudharshan, Deepa Rajamani, Susan J. Hayes, Deirdre C. Lawe, Silvia Corvera, and David G. Lambright

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Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha, Linda C. Gilbert, Xiaofei He, Paul K. Farmer, Janet Rubin, Hicham Drissi, Andre J. Van Wijnen, Jane B. Lian, Gary S. Stein, and Mark S. Nanes

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Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites, David G. Gourley, Alexander W. Schuttelkopf, Gordon A. Leonard, James Luba, Larry W. Hardy, Stephen M. Beverley, and William N. Hunter

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Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing, Alla Grishok, Amy E. Pasquinelli, Darryl Conte Jr., Na Li, Susan Parrish, Ilho Ha, David L. Baillie, Andrew Z. Fire, Gary Ruvkun, and Craig C. Mello

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Interaction between the noncatalytic region of Sid1p kinase and Cdc14p is required for full catalytic activity and localization of Sid1p, David A. Guertin and Dannel McCollum

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CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression, Soraya E. Gutierrez, Amjad Javed, Daniel K. Tennant, Monique van Rees, Martin A. Montecino, Gary S. Stein, Janet L. Stein, and Jane B. Lian

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Motor function and regulation of myosin X, Kazuaki Homma, Junya Saito, Reiko Ikebe, and Mitsuo Ikebe

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The core of the motor domain determines the direction of myosin movement, Kazuaki Homma, Misako Yoshimura, Junya Saito, Reiko Ikebe, and Mitsuo Ikebe

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Skin allograft maintenance in a new synchimeric model system of tolerance, Neal N. Iwakoshi, Thomas G. Markees, Nicole A. Turgeon, Thomas B. Thornley, Amy Cuthbert, Jean Leif, Nancy E. Phillips, John P. Mordes, Dale L. Greiner, and Aldo A. Rossini

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Contributions of nuclear architecture and chromatin to vitamin D-dependent transcriptional control of the rat osteocalcin gene, Jane B. Lian, Janet L. Stein, Gary S. Stein, Martin Montecino, Andre J. Van Wijnen, Amjad Javed, and Soraya E. Gutierrez

Distinct roles of frontal and rear cell-substrate adhesions in fibroblast migration, Steven Munevar, Yu-Li Wang, and Micah Dembo

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Human RAD52 exhibits two modes of self-association, Wasantha Ranatunga, Doba Jackson, Janice A. Lloyd, Anthony L. Forget, Kendall L. Knight, and Gloria E. O. Borgstahl

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The Ras-ERK pathway is required for the induction of neuronal nitric oxide synthase in differentiating PC12 cells, Christopher M. Schonhoff, Dylan A. Bulseco, Deborah Marie Brancho, Luis F. Parada, and Alonzo H. Ross

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An atypical population of NK cells that spontaneously secrete IFN-gamma and IL-4 is present in the intraepithelial lymphoid compartment of the rat, Derrick James Todd, Dale L. Greiner, Aldo A. Rossini, John P. Mordes, and Rita Bortell

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Tissue-engineered spinal cord, Martin P. Vacanti, Jack L. Leonard, Benjamin Dore, Lawrence J. Bonassar, Yi Lin Cao, Stanley J. Stachelek, Joseph P. Vacanti, F. OâConnell, C. S. Yu, Alan P. Farwell, and Charles A. Vacanti

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Independent regulation of lymphocytic choriomeningitis virus-specific T cell memory pools: relative stability of CD4 memory under conditions of CD8 memory T cell loss, Steven Michael Varga, Liisa K. Selin, and Raymond M. Welsh

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Immunopathology in RSV infection is mediated by a discrete oligoclonal subset of antigen-specific CD4(+) T cells, Steven Michael Varga, Xiaoting Z. Wang, Raymond M. Welsh, and Thomas J. Braciale

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High frequency of virus-specific interleukin-2-producing CD4(+) T cells and Th1 dominance during lymphocytic choriomeningitis virus infection, Steven Michael Varga and Raymond M. Welsh

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Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish, Nikolaos Vlachakis, Seong-Kyu Choe, and Charles G. Sagerstrom

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The cell cycle control element of histone H4 gene transcription is maximally responsive to interferon regulatory factor pairs IRF-1/IRF-3 and IRF-1/IRF-7, Ronglin Xie, Andre J. Van Wijnen, Caroline M. J. van der Meijden, Mai X. Luong, Janet L. Stein, and Gary S. Stein

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Determinants of the broad recognition of exocytic Rab GTPases by Mss4, Zhongyuan Zhu, Anna M. Delprato, Eric Lee Merithew, and David G. Lambright

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A helical turn motif in Mss4 is a critical determinant of Rab binding and nucleotide release, Zhongyuan Zhu, John J. Dumas, Susan E. Lietzke, and David G. Lambright

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Construction of centrosomes and spindle poles by molecular motor-driven assembly of protein particles, Wendy Cherie Zimmerman and Stephen J. Doxsey

Publications from 2000

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A profound deficiency in thymic progenitor cells in mice lacking Jak3, Allison Michelle Baird, Julie Ann Lucas, and Leslie J. Berg

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Functional delineation of three groups of the ATP-dependent family of chromatin remodeling enzymes, Laurie A. Boyer, Colin Logie, Edgar Bonte, Peter B. Becker, Paul A. Wade, Alan P. Wolffe, Carl Wu, Anthony N. Imbalzano, and Craig L. Peterson

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Actin-related proteins (Arps): conformational switches for chromatin-remodeling machines, Laurie A. Boyer and Craig L. Peterson

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Roles of the histone H2A-H2B dimers and the (H3-H4)(2) tetramer in nucleosome remodeling by the SWI-SNF complex, Laurie A. Boyer, Xiao Shao, Richard H. Ebright, and Craig L. Peterson

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Role of human cytomegalovirus immediate-early proteins in cell growth control, Jonathan Patrick Castillo, Andrew D. Yurochko, and Timothy F. Kowalik

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JNK1 is required for T cell-mediated immunity against Leishmania major infection, Stephanie L. Constant, Chen Dong, Derek D. Yang, Mark Allen Wysk, Roger J. Davis, and Richard A. Flavell

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The kinetic mechanism of the hairpin ribozyme in vivo: influence of RNA helix stability on intracellular cleavage kinetics, Christine Patricia Donahue, Ramesh S. Yadava, Steven M. Nesbitt, and Martha J. Fedor

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Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene, Hicham Drissi, Quyen Luc, A. Rauf Shakoori, Susana Chuva De Sousa Lopes, Je-Yong Choi, Anne Terry, Ming Hu, Stephen N. Jones, James C. Neil, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein

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Molecular determinants that mediate selective activation of p38 MAP kinase isoforms, Herve Enslen, Deborah Marie Brancho, and Roger J. Davis

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A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function, Nicole E. Faulkner, Denis L. Dujardin, Chin-Yin Tai, Kevin T. Vaughan, Christopher B. O'Connell, Yu-Li Wang, and Richard B. Vallee

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Modified intranuclear organization of regulatory factors in human acute leukemias: reversal after treatment, Jeffrey A. Gordon, Shirwin M. Pockwinse, F. Marc Stewart, Peter J. Quesenberry, Tatsuya Nakamura, Carlo M. Croce, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein

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Genetic requirements for inheritance of RNAi in C. elegans, Alla Grishok, Hiroaki Tabara, and Craig C. Mello

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The role of the sid1p kinase and cdc14p in regulating the onset of cytokinesis in fission yeast, David A. Guertin, Louise Chang, Farid Irshad, K. Lance Gould, and Dannel McCollum

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ATP-dependent substrate occlusion by the human erythrocyte sugar transporter, Karen Schray Heard, Nancy J. Fidyk, and Anthony Carruthers

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Snail/slug family of repressors: slowly going into the fast lane of development and cancer, Kirugaval Hemavathy, Shovon Imtiaz Ashraf, and Y. Tony Ip

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Expression screening of factors binding to the osteocalcin bone-specific promoter element OC box I: isolation of a novel osteoblast differentiation-specific factor, Heidi M. Hoffmann, Jack Green, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian

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Mob1p interacts with the Sid2p kinase and is required for cytokinesis in fission yeast, Ming-Chin Hou, Jeffrey Salek, and Dannel McCollum

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SWI-SNF-mediated nucleosome remodeling: role of histone octamer mobility in the persistence of the remodeled state, Mariela Jaskelioff, Igor M. Gavin, Craig L. Peterson, and Colin Logie

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Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription, Amjad Javed, Bo Guo, Scott W. Hiebert, Je-Yong Choi, Jack Green, Shan-Chuan Zhao, Mark A. Osborne, Stefano Stifani, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, and Gary S. Stein

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Tolerance to acute ethanol inhibition of peptide hormone release in the isolated neurohypophysis, Thomas K. Knott, Govindan Dayanithi, Vincent Coccia, Edward E. Custer, Jose R. Lemos, and Steven N. Treistman

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A role for nuclear PTEN in neuronal differentiation, Mahesh B. Lachyankar, Nazneen Sultana, Christopher M. Schonhoff, Prasenjit Mitra, Wojciech Poluha, Stephen Lambert, Peter J. Quesenberry, N. Scott Litofsky, Lawrence D. Recht, Roya Nabi, Susan J. Miller, Shinji Ohta, Benjamin G. Neel, and Alonzo H. Ross

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Marrow transplantation and targeted gene therapy to the skeleton, Jane B. Lian, Gary S. Stein, Janet L. Stein, and Andre J. Van Wijnen

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Transcriptional control of osteoblast differentiation, Jane B. Lian, Gary S. Stein, Janet L. Stein, and Andre J. Van Wijnen

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Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p, Alan B. Maderazo, Feng He, David A. Mangus, and Allan Jacobson

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Role of the cytoplasmic segments of Sec61alpha in the ribosome-binding and translocation-promoting activities of the Sec61 complex, David Raden, Weiqun Song, and Reid Gilmore

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Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines, Christine Rauh-Adelmann, Kin-Mang Lau, Nari Sabeti, John P. Long, Samuel C. Mok, and Shuk-Mei Ho

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X-Ray crystal structure and molecular dynamics simulations of silver hake parvalbumin (Isoform B), Robert C. Richardson, Nancy M. King, Daniel John Harrington, Hongmao Sun, William E. Royer, and Donald J. Nelson

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Structural hierarchy in erythrocruorin, the giant respiratory assemblage of annelids, William E. Royer, Kristen Strand, Marin van Heel, and Wayne A. Hendrickson

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Expression of a human coxsackie/adenovirus receptor transgene permits adenovirus infection of primary lymphocytes, Madelyn R. Schmidt, Brian Piekos, Mark S. Cabatingan, and Robert T. Woodland

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Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses, Liisa K. Selin, Meei-Yun Lin, Kristy A. Kraemer, Drew M. Pardoll, Jonathan P. Schneck, Steven Michael Varga, Paul A. Santolucito, Amelia K. Pinto, and Raymond M. Welsh

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NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells, Leonard D. Shultz, Pamela A. Lang, Sherri W. Christianson, Bruce Gott, Bonnie L. Lyons, Syuji Umeda, Edward H. Leiter, RuthAnn M. Hesselton, Eric J. Wagar, Jean H. Leif, Orit Kollet, Tsvee Lapidot, and Dale L. Greiner

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Role of Sec61alpha in the regulated transfer of the ribosome-nascent chain complex from the signal recognition particle to the translocation channel, Weiqun Song, David L. Raden, Elisabet C. Mandon, and Reid Gilmore

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Sensitivity of bacteriophage RB69 DNA polymerase to N2-(p-n-butylphenyl)-2'-deoxyguanosine nucleotides, James Michael Walker Stattel and George E. Wright

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Interrelationships of transcriptional machinery with nuclear architecture, Gary S. Stein, Andre J. Van Wijnen, Janet L. Stein, and Jane B. Lian

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Intranuclear trafficking of transcription factors: implications for biological control, Gary S. Stein, Andre J. Van Wijnen, Janet L. Stein, Jane B. Lian, Martin A. Montecino, Je-Yong Choi, Kaleem Zaidi, and Amjad Javed

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A plasticizer released from IV drip chambers elevates calcium levels in neurosecretory terminals, Keith Tully, David Kupfer, Alejandro M. Dopico, and Steven N. Treistman

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Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice, Eric J. Wagar, Mary A. Cromwell, Leonard D. Shultz, Bruce A. Woda, John L. Sullivan, RuthAnn M. Hesselton, and Dale L. Greiner

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Homo-oligomeric complexes of the yeast alpha-factor pheromone receptor are functional units of endocytosis, Ayce Yesilaltay and Duane D. Jenness

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Cytoplasmic dynein-mediated assembly of pericentrin and gamma tubulin onto centrosomes, Aaron Isadore Young, Jason B. Dictenberg, Aruna Purohit, Richard A. Tuft, and Stephen J. Doxsey

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Bystander sensitization to activation-induced cell death as a mechanism of virus-induced immune suppression, Christopher C. Zarozinski, James M. McNally, Barbara L. Lohman, Keith A. Daniels, and Raymond M. Welsh

Publications from 1999

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The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses, Mary-Alice Abbott, David G. Wells, and Justin R. Fallon

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AP-1 and vitamin D receptor (VDR) signaling pathways converge at the rat osteocalcin VDR element: requirement for the internal activating protein-1 site for vitamin D-mediated trans-activation, Fauzia Aslam, Laura R. McCabe, Baruch Frenkel, Andre J. Van Wijnen, Gary S. Stein, Jane B. Lian, and Janet L. Stein

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The travels of mRNAs through all cells large and small, Gary J. Bassell, Yuri Oleynikov, and Robert H. Singer

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Overexpression of truncated Nmd3p inhibits protein synthesis in yeast, Jonathan Philip Belk, Feng He, and Allan Jacobson

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Hepatic iron concentration: noninvasive estimation by means of MR imaging techniques, Herbert L. Bonkovsky, Richard B. Rubin, Edward Earl Cable, Ashley Davidoff, Tammo H. Pels Rijcken, and David D. Stark

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Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment, Yin Ching I. Chen, Anna-Liisa Brownell, Wendy R. Galpern, Ole Isacson, Mikhail Bogdanov, M. Flint Beal, Eli Livni, Bruce R. Rosen, and Bruce G. Jenkins

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Alcohol modulation of calcium-activated potassium channels, Alejandro M. Dopico, Benson Chu, Jose R. Lemos, and Steven N. Treistman