Title

Innate immune response and hepatic inflammation

UMMS Affiliation

Department of Medicine, Division of Gastroenterology; Department of Medicine, Rheumatology Division

Publication Date

2007-11-06

Document Type

Article

Subjects

Animals; Cytokines; Humans; Immunity, Innate; Inflammation; Liver; Liver Diseases; Models, Biological

Disciplines

Gastroenterology | Hepatology | Immunology and Infectious Disease

Abstract

Inflammation is a pathogenic component of various types of acute and chronic liver diseases, and it contributes to progressive liver damage and fibrosis. Cells of the innate immune system initiate and maintain hepatic inflammation though mediator production as a result of their activation by pathogen-derived products recognized by pattern recognition receptors. Innate immune cells, particularly dendritic cells, have a pivotal role in sensing pathogens and initiating adaptive immune responses by activation and regulation of T-lymphocyte responses. Although the liver provides a "tolerogenic" immune environment for antigen-specific T-cells, activation of Kupffer cells, recruited macrophages, and inflammatory cells results in production of cytokines and chemokines that can lead to prolonged inflammation, hepatocyte damage, and/or cholestasis. The specificity of Toll-like receptors and the mechanisms of innate immune cell activation are discussed in relation to acute and chronic liver injury including viral, alcoholic, nonalcoholic, and drug-induced hepatitis.

DOI of Published Version

10.1055/s-2007-991511

Source

Semin Liver Dis. 2007 Nov;27(4):339-50. Link to article on publisher's site

Journal/Book/Conference Title

Seminars in liver disease

Related Resources

Link to Article in PubMed

PubMed ID

17979071

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