Title

Liver in sepsis and systemic inflammatory response syndrome

UMMS Affiliation

Department of Medicine, Division of Gastroenterology

Publication Date

1-9-2003

Document Type

Article

Subjects

Apoptosis; Carbon Monoxide; Cholestasis; Cytokines; Heat-Shock Proteins; Hemodynamics; Humans; Lipopolysaccharides; Liver Diseases; Nitric Oxide; Sepsis; Systemic Inflammatory Response; Syndrome

Disciplines

Gastroenterology | Hepatology

Abstract

In patients with sepsis and SIRS, the liver has two opposing roles: a source of inflammatory mediators and a target organ for the effects of the inflammatory mediators. The liver is pivotal in modulating the systemic response to severe infection, because it contains the largest mass of macrophages (Kupffer cells) in the body; these macrophages can clear the endotoxin and bacteria that initiate the systemic inflammatory response. This article summarizes the functional changes that take place in the liver during sepsis and systemic inflammatory response syndrome and discusses the cellular and molecular mechanisms that underlie clinical outcomes.

Source

Clin Liver Dis. 2002 Nov;6(4):1045-66, x.

Journal/Book/Conference Title

Clinics in liver disease

Related Resources

Link to Article in PubMed

PubMed ID

12516206

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