Title

HCV immunopathogenesis: virus-induced strategies against host immunity

UMMS Affiliation

Department of Medicine, Division of Gastroenterology

Publication Date

12-14-2006

Document Type

Article

Subjects

Antibody Formation; Hepacivirus; Hepatitis C, Chronic; Humans; Immunity, Innate

Disciplines

Gastroenterology | Hepatology

Abstract

Worldwide more than 170 million people are chronically infected with the hepatitis C virus (HCV), which is a frequent cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Unlike infection with other hepatotropic viruses, only a small percentage of acute HCV infections are cleared, and most infected individuals develop lifelong HCV infection in the absence of efficient treatment. It is believed that both viral and host factors contribute to the inability of the host immune system to clear the initial infection and lead to the high propensity of chronic HCV infection.

DOI of Published Version

10.1016/j.cld.2006.08.028

Source

Clin Liver Dis. 2006 Nov;10(4):753-71. Link to article on publisher's site

Journal/Book/Conference Title

Clinics in liver disease

Related Resources

Link to Article in PubMed

PubMed ID

17164116

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