Pattern recognition receptors: a contemporary view on liver diseases
UMass Chan Affiliations
Department of Medicine, Rheumatology DivisionDepartment of Medicine, Division of Gastroenterology
Document Type
Journal ArticlePublication Date
2006-07-28Keywords
AnimalsBiological Markers
Humans
Liver Diseases
Receptors, Pattern Recognition
Gastroenterology
Hepatology
Rheumatology
Metadata
Show full item recordAbstract
Pattern recognition receptors (PRRs) function as sensors of microbial danger signals enabling the vertebrate host to initiate an immune response. PRRs are present not only in immune cells but also in liver parenchymal cells and the complexity of the cell populations provide unique aspects to pathogen recognition and tissue damage in the liver. This review discusses the role of different PRRs in pathogen recognition in the liver, and focuses on the role of PRRs in hepatic inflammation, cholestasis, ischemia, repair and fibrosis. PRRs as novel therapeutic targets are evaluated.Source
Hepatology. 2006 Aug;44(2):287-98. Link to article on publisher's siteDOI
10.1002/hep.21308Permanent Link to this Item
http://hdl.handle.net/20.500.14038/31128PubMed ID
16871558Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1002/hep.21308