Title

Inhibitory effect of monocyte reactive antibodies on monocyte chemotaxis in systemic lupus erythematosus

UMMS Affiliation

Department of Medicine, Division of Gastroenterology

Publication Date

1-1-1985

Document Type

Article

Subjects

Antibodies, Monoclonal; Antibody-Dependent Cell Cytotoxicity; Autoantibodies; Chemotaxis, Leukocyte; Cytotoxicity, Immunologic; Humans; Lupus Erythematosus, Systemic; Monocytes

Disciplines

Gastroenterology | Immunology and Infectious Disease

Abstract

Presence of different types of autoantibodies is a basic feature of systemic lupus erythematosus (SLE). Though monocytes, macrophages play an important role in cellular immunity, autoantibodies against monocytes have not been sufficiently studied. The authors used automatic fluorochromatic assay to detect monocyte reactive autoantibodies in the sera of SLE patients. Of SLE 35.5% sera showed complement-mediated monocytotoxic activity against healthy monocytes. Monocyte reactive SLE sera as well as monoclonal antibodies against human monocytes inhibited chemotaxis of control monocytes. The results suggest that monocyte reactive autoantibodies may play a role in the decreased monocyte number and defective monocyte functions observed in SLE.

Source

Haematologia (Budap). 1985;18(3):175-83.

Journal/Book/Conference Title

Haematologia

Related Resources

Link to Article in PubMed

PubMed ID

3836156

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