Effects of immune complexes from SLE patients on human monocyte locomotion and Fc receptor function

UMMS Affiliation

Department of Medicine, Division of Gastroenterology



Document Type


Medical Subject Headings

Antibodies, Antinuclear; Antigen-Antibody Complex; *Chemotaxis, Leukocyte; Complement C3; Enzyme-Linked Immunosorbent Assay; Female; Glomerulonephritis; Humans; Immunoglobulin G; Lupus Erythematosus, Systemic; Male; Monocytes; Receptors, Fc; Rosette Formation


Immune System Diseases | Rheumatology


The effect of immune complexes (IC) isolated from systemic lupus erythematosus (SLE) sera with polyethylene glycol and gel filtration on the chemotaxis and Fc receptor function of healthy monocytes was examined. Even at a low protein concentration (1 microgram/ml = 1 mg/l) ICs inhibit monocyte chemotaxis. ICs from patients with SLE nephritis are more inhibitory than ICs from patients without renal disease. The inhibitory effects of ICs on monocyte chemotaxis and Fc receptor activity are similar, suggesting a relationship between the chemotactic and Fc receptor function of monocytes. Analysis of the ICs by enzyme-linked immunoassay showed no correlation between the quantity of IgG, C3, and anti-DNA in the IC samples and their effects on monocyte function.

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Citation: Ann Rheum Dis. 1984 Oct;43(5):729-33.

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