Innate immune cell networking in hepatitis C virus infection
Department of Medicine, Division of Gastroenterology
Digestive System Diseases | Gastroenterology | Hepatology | Immunology of Infectious Disease | Immunopathology
Persistent viral infection, such as HCV infection, is the result of the inability of the host immune system to mount a successful antiviral response, as well as the escape strategies devised by the virus. Although each individual component of the host immune system plays important roles in antiviral immunity, the interactive network of immune cells as a whole acts against the virus. The innate immune system forms the first line of host defense against viral infection, and thus, virus elimination or chronic HCV infection is linked to the direct outcome of the interactions between the various innate immune cells and HCV. By understanding how the distinct components of the innate immune system function both individually and collectively during HCV infection, potential therapeutic targets can be identified to overcome immune dysfunction and control chronic viral infection.
DOI of Published Version
J Leukoc Biol. 2014 Jul 7. doi:10.1189/jlb.4MR0314-141R Link to article on publisher's site
Journal of leukocyte biology
Saha B, Szabo G. (2014). Innate immune cell networking in hepatitis C virus infection. Gastroenterology Publications. https://doi.org/10.1189/jlb.4MR0314-141R. Retrieved from https://escholarship.umassmed.edu/gastroenterology_pp/129