Title

Hypoxia and hypoxia inducible factors: diverse roles in liver diseases

UMMS Affiliation

Department of Medicine, Division of Gastroenterology

Publication Date

2012-2

Document Type

Article

Subjects

Acetaminophen; Animals; Anoxia; Humans; Hypoxia-Inducible Factor 1; Immunity, Innate; Lipid Metabolism; Liver; Liver Diseases; *Liver Regeneration; Metals; Oxygen; Reperfusion Injury; Sleep Apnea, Obstructive

Disciplines

Digestive System Diseases | Gastroenterology | Hepatology | Immunology and Infectious Disease

Abstract

Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The hypoxia inducible factors (HIFs) are a family of evolutionarily conserved transcriptional regulators that affect a homeostatic response to low oxygen tension and have been identified as key mediators of angiogenesis, inflammation, and metabolism. In this review we summarize the evidence for a role of HIFs across a range of hepatic pathophysiology. We describe regulation of the HIFs and review investigations that demonstrate a role for HIFs in the development of liver fibrosis, activation of innate immune pathways, hepatocellular carcinoma, as well as other liver diseases in both human disease as well as murine models.

DOI of Published Version

10.1002/hep.25497

Source

Hepatology. 2012 Feb;55(2):622-33. doi: 10.1002/hep.25497. Link to article on publisher's site

Journal/Book/Conference Title

Hepatology (Baltimore, Md.)

Related Resources

Link to Article in PubMed

PubMed ID

22120903

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