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UMass Chan Affiliations
Department of Medicine, Division of GastroenterologyDocument Type
Journal ArticlePublication Date
2012-09-01Keywords
InflammasomesLiver Diseases
Digestive System Diseases
Gastroenterology
Hepatology
Immunology and Infectious Disease
Metadata
Show full item recordAbstract
Inflammation is a common element in the pathogenesis of most chronic liver diseases that lead to fibrosis and cirrhosis. Inflammation is characterized by activation of innate immune cells and production of pro-inflammatory cytokines IL-1alpha, IL-1beta, and TNFalpha. Inflammasomes are intracellular multiprotein complexes expressed in both parenchymal and non-parenchymal cells of the liver that in response to cellular danger signals activate caspase-1, and release IL-1beta and IL-18. The importance of inflammasome activation in various forms of liver diseases in relation to liver damage, steatosis, inflammation and fibrosis is discussed in this review. Elsevier B.V. All rights reserved.Source
J Hepatol. 2012 Sep;57(3):642-54. Epub 2012 May 23. Link to article on publisher's site
DOI
10.1016/j.jhep.2012.03.035Permanent Link to this Item
http://hdl.handle.net/20.500.14038/31045PubMed ID
22634126Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.jhep.2012.03.035