The Department of Medicine's Division of Gastroenterology at the University of Massachusetts Medical School is dedicated to excellence in patient care, research and medical education. Our staff is committed to providing the highest quality of care to individuals as well as to the community. We strive to advance patient care through excellence in clinical, basic and translational research, and to educate future health care professionals. The high standards set by the division and the scope of services available ensure that patients will receive the best care possible for a wide variety of gastrointestinal and liver diseases. This collection showcases journal articles, book chapters, and other publications and presentations written by faculty and researchers in the Division of Gastroenterology.

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Publications from 2018

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The Morbidity and Mortality of Laparoscopic Appendectomy in Patients with Cirrhosis, Yasir Al-Azzawai, Yasir Al-Abboodi, Matthew J. Fasullo, and Tarek Najuib

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Acute-on-Chronic Liver Failure: Getting ready for prime-time, Jasmohan S. Bajaj, Richard Moreau, Patrick S. Kamath, Hugo E. Vargas, Vicente Arroyo, K. Rajender Reddy, Gyongyi Szabo, Puneeta Tandon, Jody Olson, Constantine Karvellas, Thierry Gustot, Jennifer C. Lai, and Florence Wong

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Comparing efficacy of lumen-apposing stents to plastic stents in the endoscopic management of mature peripancreatic fluid collections: a single-center experience, Matthew J. Fasullo, Yasir Al-Azzawai, Joan Kheder, Jeffrey Abergel, and Wahid Y. Wassef

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The conundrum of indeterminate QuantiFERON-TB Gold results before anti-tumor necrosis factor initiation, Shahrad Hakimian, Yevgeniy Popov, Abbas Rupawala, Karen I. Salomon-Escoto, Steven Hatch, and Randall Pellish

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Suspected Blood Indicator to Identify Active Gastrointestinal Bleeding: A Prospective Validation, Samuel Han, Julien Fahed, and David R. Cave

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Periostin and mesothelin: Potential predictors of malignant progression in intrahepatic cholangiocarcinoma, Pranoti Mandrekar and Vincenzo Cardinale

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MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease, Abhishek Satishchandran, Aditya Ambade, Sitara Rao, Ying-Chao Hsueh, Arvin Iracheta-Vellve, David Tornai, Patrick Lowe, Benedek Gyongyosi, Jia Li, Donna Catalano, Li Zhong, Karen Kodys, Jun Xie, Shashi Bala, Guangping Gao, and Gyongyi Szabo

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Approach to the Diagnostic Workup and Management of Small Bowel Lesions at a Tertiary Care Center (poster), David Stein, Jonathan Green, Christopher R. Schlieve, Ann K. Friedrich, Kevin P. Baratta, David H. Ma, May Min, Krunal Patel, David R. Cave, Demetrius E. M. Litwin, and Mitchell A. Cahan

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Gut-liver axis beyond the microbiome: How the fungal mycobiome contributes to alcoholic liver disease., Gyongyi Szabo

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More than meets the eye: Severe alcoholic hepatitis can present as acute-on-chronic liver failure, Gyongyi Szabo

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HIV-1 unmasks the plasticity of innate lymphoid cells, Yetao Wang, Kyle Gellatly, Alan G. Derr, Smita Jaiswal, Alper Kucukural, Patrick McDonel, Thomas C. Greenough, JeanMarie Houghton, Manuel Garber, and Jeremy Luban

Publications from 2017

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Cannabis use is associated with reduced prevalence of non-alcoholic fatty liver disease: A cross-sectional study, Adeyinka Adejumo, Samson Alliu, Tokunbo Opeyemi Ajayi, Kelechi Lauretta Adejumo, Oluwole Muyiwa Adegbala, Nnaemeka Egbuna Onyeakusi, Akintunde Micheal Akinjero, Modupeoluwa Durojaiye, and Terence N. Bukong

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Alcohol-induced miR-155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease, Shashi Bala, Timea Csak, Karen Kodys, Donna Catalano, Aditya Ambade, Istvan Furi, Patrick Lowe, Yeonhee Cho, Arvin Iracheta-Vellve, and Gyongyi Szabo

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Krill Oil-In-Water Emulsion Protects against Lipopolysaccharide-Induced Proinflammatory Activation of Macrophages In Vitro, Gabriel A. Bonaterra, David F. Driscoll, Hans Schwarzbach, and Ralf Kinscherf

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Microscopic Colitis After Fecal Microbiota Transplant, Matthew J. Fasullo, Yasir Al-Azzawi, and Jeffrey Abergel

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Extracellular vesicle isolation: present and future, Istvan Furi, Fatemeh Momen-Heravi, and Gyongyi Szabo

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Clostridium difficile in Inflammatory Bowel Disease: A Retrospective Study, William Gillespie, Neil Marya, Julien Fahed, Gregory Leslie, Krunal Patel, and David R. Cave

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Sepsis in Alcohol-related Liver Disease, Thierry Gustot, Javier Fernandez, Gyongyi Szabo, Agustin Albillos, Alexandre Louvet, Rajiv Jalan, Richard Moreau, and Christophe Moreno

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Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice, Arvin Iracheta-Vellve, Jan Petrasek, Benedek Gyongyosi, Shashi Bala, Timea Csak, Karen Kodys, and Gyongyi Szabo

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IL-1alpha in acetaminophen toxicity: a sterile danger signal, Arvin Iracheta-Vellve and Gyongyi Szabo

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Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice, Patrick Lowe, Benedek Gyongyosi, Abhishek Satishchandran, Arvin Iracheta-Vellve, Aditya Ambade, Karen Kodys, Donna Catalano, Doyle V. Ward, and Gyongyi Szabo

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Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease, Patrick Lowe, Benedek Gyongyosi, Doyle V. Ward, and Gyongyi Szabo

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Carcinoids and Capsules: A Case Series Highlighting the Utility of Capsule Endoscopy in Patients With Small Bowel Carcinoids, Michael G. Noujaim, Jonathan Green, May Min, Christopher R. Schlieve, Krunal Patel, Mitchell A. Cahan, and David R. Cave

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Alcohol and Cancer: Mechanisms and Therapies, Anuradha Ratna and Pranoti Mandrekar

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Circulating and Exosome-Packaged Hepatitis C Single-Stranded RNA Induce Monocyte Differentiation via TLR7/8 to Polarized Macrophages and Fibrocytes, Banishree Saha, Karen Kodys, Adeyinka Adejumo, and Gyongyi Szabo

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Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets, Gyongyi Szabo and Fatemeh Momen-Heravi

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Gut-liver axis and sterile signals in the development of alcoholic liver disease, Gyongyi Szabo and Jan Petrasek

Publications from 2016

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Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease, Aditya Ambade, Abhishek Satishchandran, Benedek Gyongyosi, Patrick Lowe, and Gyongyi Szabo

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Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1alphainduced IL-10, Aditya Ambade, Abhishek Satishchandran, Banishree Saha, Benedek Gyongyosi, Patrick Lowe, Karen Kodys, Donna Catalano, and Gyongyi Szabo

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Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1alpha activation, Aditya Ambade, Abhishek Satishchandran, and Gyongyi Szabo

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The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis, Shashi Bala, Timea Csak, Banishree Saha, James Zatsiorsky, Karen Kodys, Donna Catalano, Abhishek Satishchandran, and Gyongyi Szabo

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Therapeutic Benefits of Spleen Tyrosine Kinase Inhibitor Administration on Binge Drinking-Induced Alcoholic Liver Injury, Steatosis, and Inflammation in Mice, Terence N. Bukong, Arvin Iracheta-Vellve, Benedek Gyongyosi, Aditya Ambade, Donna Catalano, Karen Kodys, and Gyongyi Szabo

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Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease, Terence N. Bukong, Arvin Iracheta-Vellve, Banishree Saha, Aditya Ambade, Abhishek Satishchandran, Benedek Gyongyosi, Patrick Lowe, Donna Catalano, Karen Kodys, and Gyongyi Szabo

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Alcohol and inflammatory responses: Highlights of the 2015 Alcohol and Immunology Research Interest Group (AIRIG) meeting, Abigail R. Cannon, Pranoti Mandrekar, and Mashkoor A. Choudhry

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Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alcoholic Hepatitis: Recommendation From the NIAAA Alcoholic Hepatitis Consortia, David W. Crabb, Gyongyi Szabo, and NIAAA Alcoholic Hepatitis Consortia

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Sexual Dimorphism in Alcohol Induced Adipose Inflammation Relates to Liver Injury, Melissa A. Fulham and Pranoti Mandrekar

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Smoking Cessation in a Chronic Pancreatitis Population, Samuel Han, Joan Kheder, Lisa Bocelli, Julien Fahed, Amy B. Wachholtz, Gregory Seward, and Wahid Y. Wassef

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Endoplasmic reticulum stress-induced hepatocellular death pathways mediate liver injury and fibrosis via Stimulator of Interferon Genes., Arvin Iracheta-Vellve, Jan Petrasek, Benedek Gyongyosi, Abhishek Satishchandran, Patrick Lowe, Karen Kodys, Donna Catalano, Charles D. Calenda, Evelyn A. Kurt-Jones, Kate A. Fitzgerald, and Gyongyi Szabo

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Thirty-day outcomes underestimate endocrine and exocrine insufficiency after pancreatic resection, Pei-Wen Lim, Kate H. Dinh, Mary E. Sullivan, Wahid Y. Wassef, Jaroslav Zivny, Giles F. Whalen, and Jennifer LaFemina

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Alcoholic hepatitis: Translational approaches to develop targeted therapies, Pranoti Mandrekar, Ramon Bataller, Hidekazu Tsukamoto, and Bin Gao

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Hepatitis C Virus-Induced Monocyte Differentiation Into Polarized M2 Macrophages Promotes Stellate Cell Activation via TGF-beta, Banishree Saha, Karen Kodys, and Gyongyi Szabo

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MicroRNA Cargo of Extracellular Vesicles from Alcohol-exposed Monocytes Signals Naive Monocytes to Differentiate into M2 Macrophages, Banishree Saha, Fatemeh Momen-Heravi, Karen Kodys, and Gyongyi Szabo

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Hepatocellular carcinoma recurrence pattern following liver transplantation and a suggested surveillance algorithm, Eduardo Scortegagna, Adib R. Karam, Shirin Sioshansi, Adel Bozorgzadeh, Curtis T. Barry, and Sarwat Hussain

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Role of MicroRNAs in NAFLD/NASH, Gyongyi Szabo and Timea Csak

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Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis, Herbert Tilg, Alexander R. Moschen, and Gyongyi Szabo

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Native and bone marrow-derived cell mosaicism in gastric carcinoma in H. pylori-infected p27-deficient mice, Songhua Zhang, Woojin Kim, Tu T. Pham, Arlin B. Rogers, JeanMarie Houghton, and Steven F. Moss

Publications from 2015

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Does Every Patient Need Colonoscopy Follow-up for Diverticulitis?, Rachel Ackerman, Justin Yamin, Anne Foley, Louise Maranda, and Benjamin Hyatt

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Biodistribution and function of extracellular miRNA-155 in mice, Shashi Bala, Timea Csak, Fatemeh Momen-Heravi, Dora Lippai, Karen Kodys, Donna Catalano, Abhishek Satishchandran, Victor R. Ambros, and Gyongyi Szabo

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MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis, Timea Csak, Shashi Bala, Dora Lippai, Karen Kodys, Donna Catalano, Arvin Iracheta-Vellve, and Gyongyi Szabo

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Identification of genetic risk for pancreatic adenocarcinoma, Kendra Flores, Kate Dinh, Erin Rouleau, Giles F. Whalen, Wahid Y. Wassef, and Jennifer LaFemina

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Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterol-sugar diet model in mice, Michal Ganz, Terence N. Bukong, Timea Csak, Banishree Saha, Jin-Kyu Park, Aditya Ambade, Karen Kodys, and Gyongyi Szabo

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Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice, Arvin Iracheta-Vellve, Jan Petrasek, Abhishek Satishchandran, Benedek Gyongyosi, Banishree Saha, Karen Kodys, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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The genetics of hepatitis C virus underlie its ability to escape humoral immunity, Jay K. Kolls and Gyongyi Szabo

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Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS, Fatemeh Momen-Heravi, Shashi Bala, Karen Kodys, and Gyongyi Szabo

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Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis, Fatemeh Momen-Heravi, Banishree Saha, Karen Kodys, Donna Catalano, Abhishek Satishchandran, and Gyongyi Szabo

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Microscopic colitis: A review of etiology, treatment and refractory disease, Tina Park, David R. Cave, and Christopher Marshall

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Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease, Jan Petrasek, Arvin Iracheta-Vellve, Banishree Saha, Abhishek Satishchandran, Karen Kodys, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1, Laurent Roybon, Teresa L. Mastracci, Joyce Li, Simon R. W. Stott, Andrew B. Leiter, Lori Sussel, Patrik Brundin, and Jia-Yi Li

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Alcohol-induced miR-27a regulates differentiation and M2 macrophage polarization of normal human monocytes, Banishree Saha, Johanna C. Bruneau, Karen Kodys, and Gyongyi Szabo

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Gaps in Knowledge and Research Priorities for Alcoholic Hepatitis, Arun J. Sanyal, Bin Gao, and Gyongyi Szabo

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Gut-liver axis in alcoholic liver disease, Gyongyi Szabo

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Inflammasome activation in the liver: Focus on alcoholic and non-alcoholic steatohepatitis, Gyongyi Szabo and Arvin Iracheta-Vellve

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Inflammasome activation and function in liver disease, Gyongyi Szabo and Jan Petrasek

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Alcohol and HCV: implications for liver cancer, Gyongyi Szabo, Banishree Saha, and Terence N. Bukong

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MicroRNAs in alcoholic liver disease, Gyongyi Szabo and Abhishek Satishchandran

Publications from 2014

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Inhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury, Aditya Ambade, Donna Catalano, Arlene Lim, Andre Kopoyan, Scott A. Shaffer, and Pranoti Mandrekar

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Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals, Shashi Bala, Miguel Marcos, Arijeet Gattu, Donna Catalano, and Gyongyi Szabo

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Continuing challenges in the diagnosis and management of obscure gastrointestinal bleeding, Veronica Baptista, Neil Marya, Anupam Singh, Abbas Rupawala, Bilal Gondal, and David R. Cave

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Modulation of cellular stress response via the erythropoietin/CD131 heteroreceptor complex in mouse mesenchymal-derived cells, Stefan Bohr, Suraj J. Patel, Radovan Vasko, Keyue Shen, Arvin Iracheta-Vellve, Jungwoo Lee, Shyam Sundhar Bale, Nilay Chakraborty, Michael Brines, Anthony Cerami, Francois Berthiaume, and Martin L. Yarmush

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A Novel Human Radixin Peptide Inhibits Hepatitis C Virus Infection at the Level of Cell Entry, Terence N. Bukong, Karen Kodys, and Gyongyi Szabo

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Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90, Terence N. Bukong, Fatemeh Momen-Heravi, Karen Kodys, Shashi Bala, and Gyongyi Szabo

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microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis, Timea Csak, Shashi Bala, Dora Lippai, Abhishek Satishchandran, Donna Catalano, Karen Kodys, and Gyongyi Szabo

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Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis, Timea Csak, Arun Pillai, Michal Ganz, Dora Lippai, Jan Petrasek, Jin-Kyu Park, Karen Kodys, Angela Dolganiuc, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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High fat diet feeding results in gender specific steatohepatitis and inflammasome activation, Michal Ganz, Timea Csak, and Gyongyi Szabo

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Perforation of the descending colon in severe acute pancreatitis: a case report and literature review, Bilal Gondal, Adedotun Ogunsua, Lacey J. Mcintosh, Yousaf Shaikh, and David R. Cave

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Micro-RNA-155 Deficiency Prevents Alcohol-Induced Serum Endotoxin Increase and Small Bowel Inflammation in Mice, Dora Lippai, Shashi Bala, Donna Catalano, Karen Kodys, and Gyongyi Szabo

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Computerized 3-dimensional localization of a video capsule in the abdominal cavity: validation by digital radiography, Neil Marya, Andrew Karellas, Anne Foley, Abhijit Roychowdhury, and David R. Cave

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Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages, Fatemeh Momen-Heravi, Shashi Bala, Terence N. Bukong, and Gyongyi Szabo

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Innate immune cell networking in hepatitis C virus infection, Banishree Saha and Gyongyi Szabo

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Converging actions of alcohol on liver and brain immune signaling, Gyongyi Szabo and Dora Lippai

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Pancreatitis Quality of Life Instrument: Development of a New Instrument, Wahid Y. Wassef, Carol A. Bova, Bruce A. Barton, and Celia Hartigan

Publications from 2013

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Targeting Heat Shock Protein 90 Alters Epigenetic Genes in Alcoholic Liver Disease, Aditya Ambade and Pranoti Mandrekar

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Ethanol facilitates HCV replication via upregulation of GW182 and HSP90 in human hepatoma cells, Terence N. Bukong, Wei Hou, Karen Kodys, and Gyongyi Szabo

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Human ezrin-moesin-radixin proteins modulate hepatitis C virus infection, Terence N. Bukong, Karen Kodys, and Gyongyi Szabo

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Another armed CD4(+) T cell ready to battle hepatocellular carcinoma, Roniel Cabrera and Gyongyi Szabo

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Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach, Jessica M. Donnelly, Ambreesh Chawla, JeanMarie Houghton, and Yana Zavros

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Immune and inflammatory pathways in NASH, Michal Ganz and Gyongyi Szabo

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Alcohol facilitates HCV RNA replication via up-regulation of miR-122 expression and inhibition of cyclin G1 in human hepatoma cells, Wei Hou, Terence N. Bukong, Karen Kodys, and Gyongyi Szabo

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Efficacy and safety of natalizumab in Crohn's disease patients treated at 6 Boston academic hospitals, Pascal Juillerat, Sharmeel K. Wasan, Sharyle A. Fowler, Sonia Friedman, Vikas K. Pabby, Jennifer A. Coukas, Amy E. Barto, Randall Pellish, Katharine A. Germansky, Adam S. Cheifetz, Joshua R. Korzenik, Francis A. Farraye, and Vijay Yajnik

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Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice, Dora Lippai, Shashi Bala, Timea Csak, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Alcohol-induced IL-1beta in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation, Dora Lippai, Shashi Bala, Jan Petrasek, Timea Csak, Ivan Levin, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation, Sujatha Muralidharan and Pranoti Mandrekar

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Differences in innate immune signaling between alcoholic and non-alcoholic steatohepatitis, Jan Petrasek, Timea Csak, Michal Ganz, and Gyongyi Szabo

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Toll-like receptors in liver disease, Jan Petrasek, Timea Csak, and Gyongyi Szabo

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STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease, Jan Petrasek, Arvin Iracheta-Vellve, Timea Csak, Abhishek Satishchandran, Karen Kodys, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, and Gyongyi Szabo

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Expression of inhibitory markers is increased on effector memory T cells during hepatitis C virus/HIV coinfection as compared to hepatitis C virus or HIV monoinfection, Banishree Saha, Manish C. Choudhary, and Shiv K. Sarin

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Binge ethanol and liver: new molecular developments, Shivendra D. Shukla, Stephen B. Pruett, Gyongyi Szabo, and Gavin E. Arteel

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Evaluation of small bowel bleeding, Anupam Singh, Veronica Baptista, Calin Stoicov, and David R. Cave

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Timing of video capsule endoscopy relative to overt obscure GI bleeding: implications from a retrospective study, Anupam Singh, Christopher Marshall, Biswashree Chaudhuri, Chidimma Okoli, Anne Foley, Sharina D. Person, Kanishka Bhattacharya, and David R. Cave

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Timing of video capsule endoscopy relative to overt obscure GI bleeding: implications from a retrospective study, Anupam Singh, Christopher Marshall, Biswashree Chaudhuri, Chidimma Okoli, Anne Foley, Sharina D. Person, Kanishka Bhattacharya, and David R. Cave