The Department of Medicine's Division of Gastroenterology at the University of Massachusetts Medical School is dedicated to excellence in patient care, research and medical education. Our staff is committed to providing the highest quality of care to individuals as well as to the community. We strive to advance patient care through excellence in clinical, basic and translational research, and to educate future health care professionals. The high standards set by the division and the scope of services available ensure that patients will receive the best care possible for a wide variety of gastrointestinal and liver diseases. This collection showcases journal articles, book chapters, and other publications and presentations written by faculty and researchers in the Division of Gastroenterology.
Publications from 2018
The conundrum of indeterminate QuantiFERON-TB Gold results before anti-tumor necrosis factor initiation, Shahrad Hakimian, Yevgeniy Popov, Abbas Rupawala, Karen I. Salomon-Escoto, Steven Hatch, and Randall Pellish
MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease, Abhishek Satishchandran, Aditya Ambade, Sitara Rao, Ying-Chao Hsueh, Arvin Iracheta-Vellve, David Tornai, Patrick Lowe, Benedek Gyongyosi, Jia Li, Donna Catalano, Li Zhong, Karen Kodys, Jun Xie, Shashi Bala, Guangping Gao, and Gyongyi Szabo
Approach to the Diagnostic Workup and Management of Small Bowel Lesions at a Tertiary Care Center (poster), David Stein, Jonathan Green, Christopher R. Schlieve, Ann K. Friedrich, Kevin P. Baratta, David H. Ma, May Min, Krunal Patel, David R. Cave, Demetrius E. M. Litwin, and Mitchell A. Cahan
Publications from 2017
Cannabis use is associated with reduced prevalence of non-alcoholic fatty liver disease: A cross-sectional study, Adeyinka Adejumo, Samson Alliu, Tokunbo Opeyemi Ajayi, Kelechi Lauretta Adejumo, Oluwole Muyiwa Adegbala, Nnaemeka Egbuna Onyeakusi, Akintunde Micheal Akinjero, Modupeoluwa Durojaiye, and Terence N. Bukong
Alcohol-induced miR-155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease, Shashi Bala, Timea Csak, Karen Kodys, Donna Catalano, Aditya Ambade, Istvan Furi, Patrick Lowe, Yeonhee Cho, Arvin Iracheta-Vellve, and Gyongyi Szabo
Krill Oil-In-Water Emulsion Protects against Lipopolysaccharide-Induced Proinflammatory Activation of Macrophages In Vitro, Gabriel A. Bonaterra, David F. Driscoll, Hans Schwarzbach, and Ralf Kinscherf
Microscopic Colitis After Fecal Microbiota Transplant, Matthew J. Fasullo, Yasir Al-Azzawi, and Jeffrey Abergel
Extracellular vesicle isolation: present and future, Istvan Furi, Fatemeh Momen-Heravi, and Gyongyi Szabo
Clostridium difficile in Inflammatory Bowel Disease: A Retrospective Study, William Gillespie, Neil Marya, Julien Fahed, Gregory Leslie, Krunal Patel, and David R. Cave
Sepsis in Alcohol-related Liver Disease, Thierry Gustot, Javier Fernandez, Gyongyi Szabo, Agustin Albillos, Alexandre Louvet, Rajiv Jalan, Richard Moreau, and Christophe Moreno
Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice, Arvin Iracheta-Vellve, Jan Petrasek, Benedek Gyongyosi, Shashi Bala, Timea Csak, Karen Kodys, and Gyongyi Szabo
IL-1alpha in acetaminophen toxicity: a sterile danger signal, Arvin Iracheta-Vellve and Gyongyi Szabo
Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice, Patrick Lowe, Benedek Gyongyosi, Abhishek Satishchandran, Arvin Iracheta-Vellve, Aditya Ambade, Karen Kodys, Donna Catalano, Doyle V. Ward, and Gyongyi Szabo
Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease, Patrick Lowe, Benedek Gyongyosi, Doyle V. Ward, and Gyongyi Szabo
Carcinoids and Capsules: A Case Series Highlighting the Utility of Capsule Endoscopy in Patients With Small Bowel Carcinoids, Michael G. Noujaim, Jonathan Green, May Min, Christopher R. Schlieve, Krunal Patel, Mitchell A. Cahan, and David R. Cave
Alcohol and Cancer: Mechanisms and Therapies, Anuradha Ratna and Pranoti Mandrekar
Circulating and Exosome-Packaged Hepatitis C Single-Stranded RNA Induce Monocyte Differentiation via TLR7/8 to Polarized Macrophages and Fibrocytes, Banishree Saha, Karen Kodys, Adeyinka Adejumo, and Gyongyi Szabo
Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets, Gyongyi Szabo and Fatemeh Momen-Heravi
Gut-liver axis and sterile signals in the development of alcoholic liver disease, Gyongyi Szabo and Jan Petrasek
Publications from 2016
Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease, Aditya Ambade, Abhishek Satishchandran, Benedek Gyongyosi, Patrick Lowe, and Gyongyi Szabo
Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1alphainduced IL-10, Aditya Ambade, Abhishek Satishchandran, Banishree Saha, Benedek Gyongyosi, Patrick Lowe, Karen Kodys, Donna Catalano, and Gyongyi Szabo
Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1alpha activation, Aditya Ambade, Abhishek Satishchandran, and Gyongyi Szabo
The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis, Shashi Bala, Timea Csak, Banishree Saha, James Zatsiorsky, Karen Kodys, Donna Catalano, Abhishek Satishchandran, and Gyongyi Szabo
Therapeutic Benefits of Spleen Tyrosine Kinase Inhibitor Administration on Binge Drinking-Induced Alcoholic Liver Injury, Steatosis, and Inflammation in Mice, Terence N. Bukong, Arvin Iracheta-Vellve, Benedek Gyongyosi, Aditya Ambade, Donna Catalano, Karen Kodys, and Gyongyi Szabo
Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease, Terence N. Bukong, Arvin Iracheta-Vellve, Banishree Saha, Aditya Ambade, Abhishek Satishchandran, Benedek Gyongyosi, Patrick Lowe, Donna Catalano, Karen Kodys, and Gyongyi Szabo
Alcohol and inflammatory responses: Highlights of the 2015 Alcohol and Immunology Research Interest Group (AIRIG) meeting, Abigail R. Cannon, Pranoti Mandrekar, and Mashkoor A. Choudhry
Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alcoholic Hepatitis: Recommendation From the NIAAA Alcoholic Hepatitis Consortia, David W. Crabb, Gyongyi Szabo, and NIAAA Alcoholic Hepatitis Consortia
Sexual Dimorphism in Alcohol Induced Adipose Inflammation Relates to Liver Injury, Melissa A. Fulham and Pranoti Mandrekar
Smoking Cessation in a Chronic Pancreatitis Population, Samuel Han, Joan Kheder, Lisa Bocelli, Julien Fahed, Amy B. Wachholtz, Gregory Seward, and Wahid Y. Wassef
Endoplasmic reticulum stress-induced hepatocellular death pathways mediate liver injury and fibrosis via Stimulator of Interferon Genes., Arvin Iracheta-Vellve, Jan Petrasek, Benedek Gyongyosi, Abhishek Satishchandran, Patrick Lowe, Karen Kodys, Donna Catalano, Charles D. Calenda, Evelyn A. Kurt-Jones, Kate A. Fitzgerald, and Gyongyi Szabo
Thirty-day outcomes underestimate endocrine and exocrine insufficiency after pancreatic resection, Pei-Wen Lim, Kate H. Dinh, Mary E. Sullivan, Wahid Y. Wassef, Jaroslav Zivny, Giles F. Whalen, and Jennifer LaFemina
Alcoholic hepatitis: Translational approaches to develop targeted therapies, Pranoti Mandrekar, Ramon Bataller, Hidekazu Tsukamoto, and Bin Gao
Hepatitis C Virus-Induced Monocyte Differentiation Into Polarized M2 Macrophages Promotes Stellate Cell Activation via TGF-beta, Banishree Saha, Karen Kodys, and Gyongyi Szabo
MicroRNA Cargo of Extracellular Vesicles from Alcohol-exposed Monocytes Signals Naive Monocytes to Differentiate into M2 Macrophages, Banishree Saha, Fatemeh Momen-Heravi, Karen Kodys, and Gyongyi Szabo
Hepatocellular carcinoma recurrence pattern following liver transplantation and a suggested surveillance algorithm, Eduardo Scortegagna, Adib R. Karam, Shirin Sioshansi, Adel Bozorgzadeh, Curtis T. Barry, and Sarwat Hussain
Role of MicroRNAs in NAFLD/NASH, Gyongyi Szabo and Timea Csak
Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis, Herbert Tilg, Alexander R. Moschen, and Gyongyi Szabo
Native and bone marrow-derived cell mosaicism in gastric carcinoma in H. pylori-infected p27-deficient mice, Songhua Zhang, Woojin Kim, Tu T. Pham, Arlin B. Rogers, JeanMarie Houghton, and Steven F. Moss
Publications from 2015
Does Every Patient Need Colonoscopy Follow-up for Diverticulitis?, Rachel Ackerman, Justin Yamin, Anne Foley, Louise Maranda, and Benjamin Hyatt
Biodistribution and function of extracellular miRNA-155 in mice, Shashi Bala, Timea Csak, Fatemeh Momen-Heravi, Dora Lippai, Karen Kodys, Donna Catalano, Abhishek Satishchandran, Victor R. Ambros, and Gyongyi Szabo
MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis, Timea Csak, Shashi Bala, Dora Lippai, Karen Kodys, Donna Catalano, Arvin Iracheta-Vellve, and Gyongyi Szabo
Identification of genetic risk for pancreatic adenocarcinoma, Kendra Flores, Kate Dinh, Erin Rouleau, Giles F. Whalen, Wahid Y. Wassef, and Jennifer LaFemina
Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterol-sugar diet model in mice, Michal Ganz, Terence N. Bukong, Timea Csak, Banishree Saha, Jin-Kyu Park, Aditya Ambade, Karen Kodys, and Gyongyi Szabo
Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice, Arvin Iracheta-Vellve, Jan Petrasek, Abhishek Satishchandran, Benedek Gyongyosi, Banishree Saha, Karen Kodys, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, and Gyongyi Szabo
The genetics of hepatitis C virus underlie its ability to escape humoral immunity, Jay K. Kolls and Gyongyi Szabo
Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS, Fatemeh Momen-Heravi, Shashi Bala, Karen Kodys, and Gyongyi Szabo
Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis, Fatemeh Momen-Heravi, Banishree Saha, Karen Kodys, Donna Catalano, Abhishek Satishchandran, and Gyongyi Szabo
Microscopic colitis: A review of etiology, treatment and refractory disease, Tina Park, David R. Cave, and Christopher Marshall
Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease, Jan Petrasek, Arvin Iracheta-Vellve, Banishree Saha, Abhishek Satishchandran, Karen Kodys, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, and Gyongyi Szabo
The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1, Laurent Roybon, Teresa L. Mastracci, Joyce Li, Simon R. W. Stott, Andrew B. Leiter, Lori Sussel, Patrik Brundin, and Jia-Yi Li
Alcohol-induced miR-27a regulates differentiation and M2 macrophage polarization of normal human monocytes, Banishree Saha, Johanna C. Bruneau, Karen Kodys, and Gyongyi Szabo
Gaps in Knowledge and Research Priorities for Alcoholic Hepatitis, Arun J. Sanyal, Bin Gao, and Gyongyi Szabo
Gut-liver axis in alcoholic liver disease, Gyongyi Szabo
Inflammasome activation in the liver: Focus on alcoholic and non-alcoholic steatohepatitis, Gyongyi Szabo and Arvin Iracheta-Vellve
Inflammasome activation and function in liver disease, Gyongyi Szabo and Jan Petrasek
Alcohol and HCV: implications for liver cancer, Gyongyi Szabo, Banishree Saha, and Terence N. Bukong
MicroRNAs in alcoholic liver disease, Gyongyi Szabo and Abhishek Satishchandran
Publications from 2014
Inhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury, Aditya Ambade, Donna Catalano, Arlene Lim, Andre Kopoyan, Scott A. Shaffer, and Pranoti Mandrekar
Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals, Shashi Bala, Miguel Marcos, Arijeet Gattu, Donna Catalano, and Gyongyi Szabo
Continuing challenges in the diagnosis and management of obscure gastrointestinal bleeding, Veronica Baptista, Neil Marya, Anupam Singh, Abbas Rupawala, Bilal Gondal, and David R. Cave
Modulation of cellular stress response via the erythropoietin/CD131 heteroreceptor complex in mouse mesenchymal-derived cells, Stefan Bohr, Suraj J. Patel, Radovan Vasko, Keyue Shen, Arvin Iracheta-Vellve, Jungwoo Lee, Shyam Sundhar Bale, Nilay Chakraborty, Michael Brines, Anthony Cerami, Francois Berthiaume, and Martin L. Yarmush
A Novel Human Radixin Peptide Inhibits Hepatitis C Virus Infection at the Level of Cell Entry, Terence N. Bukong, Karen Kodys, and Gyongyi Szabo
Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90, Terence N. Bukong, Fatemeh Momen-Heravi, Karen Kodys, Shashi Bala, and Gyongyi Szabo
microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis, Timea Csak, Shashi Bala, Dora Lippai, Abhishek Satishchandran, Donna Catalano, Karen Kodys, and Gyongyi Szabo
Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis, Timea Csak, Arun Pillai, Michal Ganz, Dora Lippai, Jan Petrasek, Jin-Kyu Park, Karen Kodys, Angela Dolganiuc, Evelyn A. Kurt-Jones, and Gyongyi Szabo
High fat diet feeding results in gender specific steatohepatitis and inflammasome activation, Michal Ganz, Timea Csak, and Gyongyi Szabo
Perforation of the descending colon in severe acute pancreatitis: a case report and literature review, Bilal Gondal, Adedotun Ogunsua, Lacey J. Mcintosh, Yousaf Shaikh, and David R. Cave
Micro-RNA-155 Deficiency Prevents Alcohol-Induced Serum Endotoxin Increase and Small Bowel Inflammation in Mice, Dora Lippai, Shashi Bala, Donna Catalano, Karen Kodys, and Gyongyi Szabo
Computerized 3-dimensional localization of a video capsule in the abdominal cavity: validation by digital radiography, Neil Marya, Andrew Karellas, Anne Foley, Abhijit Roychowdhury, and David R. Cave
Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages, Fatemeh Momen-Heravi, Shashi Bala, Terence N. Bukong, and Gyongyi Szabo
Innate immune cell networking in hepatitis C virus infection, Banishree Saha and Gyongyi Szabo
Converging actions of alcohol on liver and brain immune signaling, Gyongyi Szabo and Dora Lippai
Pancreatitis Quality of Life Instrument: Development of a New Instrument, Wahid Y. Wassef, Carol A. Bova, Bruce A. Barton, and Celia Hartigan
Publications from 2013
Targeting Heat Shock Protein 90 Alters Epigenetic Genes in Alcoholic Liver Disease, Aditya Ambade and Pranoti Mandrekar
Ethanol facilitates HCV replication via upregulation of GW182 and HSP90 in human hepatoma cells, Terence N. Bukong, Wei Hou, Karen Kodys, and Gyongyi Szabo
Human ezrin-moesin-radixin proteins modulate hepatitis C virus infection, Terence N. Bukong, Karen Kodys, and Gyongyi Szabo
Another armed CD4(+) T cell ready to battle hepatocellular carcinoma, Roniel Cabrera and Gyongyi Szabo
Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach, Jessica M. Donnelly, Ambreesh Chawla, JeanMarie Houghton, and Yana Zavros
Immune and inflammatory pathways in NASH, Michal Ganz and Gyongyi Szabo
Alcohol facilitates HCV RNA replication via up-regulation of miR-122 expression and inhibition of cyclin G1 in human hepatoma cells, Wei Hou, Terence N. Bukong, Karen Kodys, and Gyongyi Szabo
Efficacy and safety of natalizumab in Crohn's disease patients treated at 6 Boston academic hospitals, Pascal Juillerat, Sharmeel K. Wasan, Sharyle A. Fowler, Sonia Friedman, Vikas K. Pabby, Jennifer A. Coukas, Amy E. Barto, Randall Pellish, Katharine A. Germansky, Adam S. Cheifetz, Joshua R. Korzenik, Francis A. Farraye, and Vijay Yajnik
Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice, Dora Lippai, Shashi Bala, Timea Csak, Evelyn A. Kurt-Jones, and Gyongyi Szabo
Alcohol-induced IL-1beta in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation, Dora Lippai, Shashi Bala, Jan Petrasek, Timea Csak, Ivan Levin, Evelyn A. Kurt-Jones, and Gyongyi Szabo
Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation, Sujatha Muralidharan and Pranoti Mandrekar
Differences in innate immune signaling between alcoholic and non-alcoholic steatohepatitis, Jan Petrasek, Timea Csak, Michal Ganz, and Gyongyi Szabo
Toll-like receptors in liver disease, Jan Petrasek, Timea Csak, and Gyongyi Szabo
STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease, Jan Petrasek, Arvin Iracheta-Vellve, Timea Csak, Abhishek Satishchandran, Karen Kodys, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, and Gyongyi Szabo
Expression of inhibitory markers is increased on effector memory T cells during hepatitis C virus/HIV coinfection as compared to hepatitis C virus or HIV monoinfection, Banishree Saha, Manish C. Choudhary, and Shiv K. Sarin
Binge ethanol and liver: new molecular developments, Shivendra D. Shukla, Stephen B. Pruett, Gyongyi Szabo, and Gavin E. Arteel
Evaluation of small bowel bleeding, Anupam Singh, Veronica Baptista, Calin Stoicov, and David R. Cave
Timing of video capsule endoscopy relative to overt obscure GI bleeding: implications from a retrospective study, Anupam Singh, Christopher Marshall, Biswashree Chaudhuri, Chidimma Okoli, Anne Foley, Sharina D. Person, Kanishka Bhattacharya, and David R. Cave
Timing of video capsule endoscopy relative to overt obscure GI bleeding: implications from a retrospective study, Anupam Singh, Christopher Marshall, Biswashree Chaudhuri, Chidimma Okoli, Anne Foley, Sharina D. Person, Kanishka Bhattacharya, and David R. Cave
Mesenchymal stem cells utilize CXCR4-SDF-1 signaling for acute, but not chronic, trafficking to gastric mucosal inflammation, Calin Stoicov, Hanchen Li, Jian Hua Liu, and JeanMarie Houghton
MicroRNAs in liver disease, Gyongyi Szabo and Shashi Bala
CD81/CD9 tetraspanins aid plasmacytoid dendritic cells in recognition of HCV-infected cells and induction of IFNalpha, Shuye Zhang, Karen Kodys, Gregory J. Babcock, and Gyongyi Szabo
Human type 2 myeloid dendritic cells produce interferon-lambda and amplify interferon-alpha in response to hepatitis C virus infection, Shuye Zhang, Karen Kodys, Kui Li, and Gyongyi Szabo
IFN-gamma production by human natural killer cells in response to HCV-infected hepatoma cells is dependent on accessory cells, Shuye Zhang, Banishree Saha, Karen Kodys, and Gyongyi Szabo
Publications from 2012
Inhibition of heat shock protein (molecular weight 90 kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice, Aditya Ambade, Donna Catalano, Arlene Lim, and Pranoti Mandrekar
Oxidative stress and inflammation: essential partners in alcoholic liver disease, Aditya Ambade and Pranoti Mandrekar
Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases, Shashi Bala, Jan Petrasek, Shiv Mundkur, Donna Catalano, Ivan Levin, Jeanine Ward, Hawau Alao, Karen Kodys, and Gyongyi Szabo