Gardner Lab Publications
This collection showcases the journal articles and other publications authored by researchers in the Gardner Lab. The Gardner Lab at the University of Massachusetts Medical School was established in 2000, in the Brudnick Neuropsychiatric Research Institute, in the Department of Psychiatry. In 2017, the Gardner Lab moved to the Department of Neurobiology.
Publications from 2017
A circuit-based mechanism underlying familiarity signaling and the preference for novelty, Susanna Molas-Casacuberta, Rubing Zhao-Shea, Liwang Liu, Steven Degroot, Paul D. Gardner, and Andrew R. Tapper
Paternal nicotine exposure alters hepatic xenobiotic metabolism in offspring, Markus P. Vallaster, Shweta Kukreja, Xin Y. Bing, Jennifer Ngolab, Rubing Zhao-Shea, Paul D. Gardner, Andrew R. Tapper, and Oliver J. Rando
Publications from 2016
Habenula cholinergic neurons regulate anxiety during nicotine withdrawal via nicotinic acetylcholine receptors, Xueyan Pang, Liwang Liu, Jennifer Ngolab, Rubing Zhao-Shea, J. Michael McIntosh, Paul D. Gardner, and Andrew R. Tapper
5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking, In-Jee You, Sherie R. Wright, Alvaro L. Garcia-Garcia, Andrew R. Tapper, Paul D. Gardner, George F. Koob, E David Leonardo, Laura M. Bohn, and Sunmee Wee
Publications from 2015
Functional Upregulation of alpha4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward, Jennifer Ngolab, Liwang Liu, Rubing Zhao-Shea, Guangping Gao, Paul D. Gardner, and Andrew R. Tapper
Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome, Jeremy Shea, Ryan W. Serra, Benjamin R. Carone, Hennady P. Shulha, Alper Kucukural, Michael Ziller, Markus Vallaster, Hongcang Gu, Andrew R. Tapper, Paul D. Gardner, Alexander Meissner, Manuel Garber, and Oliver J. Rando
Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal, Rubing Zhao-Shea, Steven Degroot, Liwang Liu, Markus Vallaster, Xueyan Pang, Qin Su, Guangping Gao, Oliver J. Rando, Gilles E. Martin, Olivier George, Paul D. Gardner, and Andrew R. Tapper
Publications from 2014
Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition, Rahul Bharadwaj, Cyril J. Peter, Yan Jiang, Panos Roussos, Annie Vogel-Ciernia, Erica Y. Shen, Amanda C. Mitchell, Wenjie Mao, Catheryne Whittle, Aslihan Dincer, Mira Jakovcevski, Venu Pothula, Theodore P. Rasmussen, Stella G. Giakoumaki, Panos Bitsios, Ajfar Sherif, Paul D. Gardner, Patricia Ernst, Subroto Ghose, Pamela Sklar, Vahram Haroutunian, Carol Tamminga, Richard H. Myers, Kensuke Futai, Marcelo A. Wood, and Schahram Akbarian
miRNAome analysis of the mammalian neuronal nicotinic acetylcholine receptor gene family, Eric M. Hogan, Alison P. Casserly, Michael D. Scofield, Zhongming Mou, Rubing Zhao-Shea, Chris W. Johnson, Andrew R. Tapper, and Paul D. Gardner
Dicer expression is essential for adult midbrain dopaminergic neuron maintenance and survival, Xueyan Pang, Eric M. Hogan, Alison Casserly, Guangping Gao, Paul D. Gardner, and Andrew R. Tapper
Publications from 2013
Conserved chromosome 2q31 conformations are associated with transcriptional regulation of GAD1 GABA synthesis enzyme and altered in prefrontal cortex of subjects with schizophrenia, Rahul Bharadwaj, Yan Jiang, Wenjie Mao, Mira Jakovcevski, Aslihan Dincer, Winfried Krueger, Krassimira Garbett, Catheryne Whittle, Jogender S. Tushir, Jia Liu, Adolfo Sequeira, Marquis P. Vawter, Paul D. Gardner, Patrizia Casaccia, Theodore Rasmussen, William E. Bunney Jr., Karoly Mirnics, Kensuke Futai, and Schahram Akbarian
Nicotinic acetylcholine receptors mediate lung cancer growth, Ma. Reina D. Improgo, Lindsey G. Soll, Andrew R. Tapper, and Paul D. Gardner
Nicotinic acetylcholine receptors containing the alpha4 subunit modulate alcohol reward, Liwang Liu, Linzy M. Hendrickson, Melissa Guildford, Rubing Zhao-Shea, Paul D. Gardner, and Andrew R. Tapper
Activation of GABAergic Neurons in the Interpeduncular Nucleus Triggers Physical Nicotine Withdrawal Symptoms, Rubing Zhao-Shea, Liwang Liu, Xueyan Pang, Paul D. Gardner, and Andrew R. Tapper
Publications from 2012
Nicotine persistently activates ventral tegmental area dopaminergic neurons via nicotinic acetylcholine receptors containing alpha4 and alpha6 subunits, Liwang Liu, Rubing Zhao-Shea, J. Michael McIntosh, Paul D. Gardner, and Andrew R. Tapper
Publications from 2011
Nicotinic acetylcholine receptors containing the alpha4 subunit are critical for the nicotine-induced reduction of acute voluntary ethanol consumption, Linzy M. Hendrickson, Paul D. Gardner, and Andrew R. Tapper
Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinoma, Ma. Reina D. Improgo, Christopher W. Johnson, Andrew R. Tapper, and Paul D. Gardner
Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer, Ma. Reina D. Improgo, Andrew R. Tapper, and Paul D. Gardner
Nicotine-mediated activation of dopaminergic neurons in distinct regions of the ventral tegmental area, Rubing Zhao-Shea, Liwang Liu, Lindsey G. Soll, Ma. Reina D. Improgo, Erin E. Meyers, J. Michael McIntosh, Sharon R. Grady, Michael J. Marks, Paul D. Gardner, and Andrew R. Tapper
Publications from 2010
Temporally- and spatially-regulated transcriptional activity of the nicotinic acetylcholine receptor beta4 subunit gene promoter., Lei Bruschweiler-Li, Yuly F. Fuentes Medel, Michael D. Scofield, Ellen B. T. Trang, Sarah A. Binke, and Paul D. Gardner
Activation of alpha4* nAChRs is necessary and sufficient for varenicline-induced reduction of alcohol consumption, Linzy M. Hendrickson, Rubing Zhao-Shea, Xueyan Pang, Paul D. Gardner, and Andrew R. Tapper
ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus, Ma Reina D. Improgo, Nicolette A. Schlichting, Roxana Y. Cortes, Rubing Zhao-Shea, Andrew R. Tapper, and Paul D. Gardner
The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer, Ma Reina D. Improgo, Michael D. Scofield, Andrew R. Tapper, and Paul D. Gardner
From smoking to lung cancer: the CHRNA5/A3/B4 connection, Ma. Reina D. Improgo, Michael D. Scofield, Andrew R. Tapper, and Paul D. Gardner
A transcriptional regulatory element critical for CHRNB4 promoter activity in vivo, Michael D. Scofield, Andrew R. Tapper, and Paul D. Gardner
Dopamine D2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive {alpha}4 nicotinic receptors via a cholinergic-dependent mechanism, Rubing Zhao-Shea, Bruce M. Cohen, Herwig Just, Tristan McClure-Begley, Paul Whiteaker, Sharon R. Grady, Outi Salminen, Paul D. Gardner, Henry A. Lester, and Andrew R. Tapper
Publications from 2009
The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10, Zhongming Mou, Andrew R. Tapper, and Paul D. Gardner
Publications from 2008
Nlz1/Znf703 acts as a repressor of transcription, Mako Nakamura, Seong-Kyu Choe, Alexander Peter Runko, Paul D. Gardner, and Charles G. Sagerstrom
Transcription factor assembly on the nicotinic receptor beta4 subunit gene promoter, Michael D. Scofield, Lei Bruschweiler-Li, Zhongming Mou, and Paul D. Gardner
Publications from 2007
Transcriptional repression by a conserved intronic sequence in the nicotinic receptor alpha3 subunit gene, Yuly F. Fuentes Medel and Paul D. Gardner
Publications from 2006
Cell-type-specific and developmental regulation of heterogeneous nuclear ribonucleoprotein K mRNA in the rat nervous system, Adam R. Blanchette, Yuly F. Fuentes Medel, and Paul D. Gardner
Publications from 2001
The signal transduction pathway underlying ion channel gene regulation by SP1-C-Jun interactions, Irena N. Melnikova and Paul D. Gardner