The impact of prior authorization on buprenorphine dose, relapse rates, and cost for Massachusetts Medicaid beneficiaries with opioid dependence

UMMS Affiliation

Department of Family Medicine and Community Health; Department of Quantitative Health Sciences; Center for Health Policy and Research; Commonwealth Medicine

Publication Date


Document Type



Adult; Analgesics, Opioid; Buprenorphine; Cohort Studies; Costs and Cost Analysis; *Drug and Narcotic Control; Female; *Health Expenditures; Humans; Male; Massachusetts; Medicaid; Opiate Substitution Treatment; Opioid-Related Disorders; Recurrence; United States


Community Health and Preventive Medicine | Family Medicine | Health Policy | Health Services Administration | Health Services Research | Preventive Medicine | Primary Care | Substance Abuse and Addiction


OBJECTIVE: To assess the impact of a 2008 dose-based prior authorization policy for Massachusetts Medicaid beneficiaries using buprenorphine + naloxone for opioid addiction treatment. Doses higher than 16 mg required progressively more frequent authorizations.

DATA SOURCES: Mediciaid claims for 2007 and 2008 linked with Department of Public Health (DPH) service records.

STUDY DESIGN: We conducted time series for all buprenorphine users and a longitudinal cohort analysis of 2,049 individuals who began buprenorphine treatment in 2007. Outcome measures included use of relapse-related services, health care expenditures per person, and buprenorphine expenditures.

DATA COLLECTION/EXTRACTION METHODS: We used ICD-9 codes and National Drug Codes to identify individuals with opioid dependence who filled prescriptions for buprenorphine. Medicaid and DPH data were linked with individual identifiers.

PRINCIPAL FINDINGS: Individuals using doses > 24 mg decreased from 16.5 to 4.1 percent. Relapses increased temporarily for some users but returned to previous levels within 3 months. Buprenorphine expenditures decreased but total expenditures did not change significantly.

CONCLUSION: Prior authorization policies strategically targeted by dose level appear to successfully reduce use of higher than recommended buprenorphine doses. Savings from these policies are modest and may be accompanied by brief increases in relapse rates. Lower doses may decrease diversion of buprenorphine.


Drug addiction treatment, Medicaid, buprenorphine, pharmaceutical policy, prior authorization

DOI of Published Version



Health Serv Res. 2014 Dec;49(6):1964-79. doi: 10.1111/1475-6773.12201. Epub 2014 Jul 9. Link to article on publisher's site

Journal/Book/Conference Title

Health services research

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Link to Article in PubMed

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