Shedding light on sperm pHertility
Department of Cell Biology
Animals; Humans; Hydrogen-Ion Concentration; Male; Membrane Potentials; Mice; *Sperm Capacitation; Spermatozoa
The acquisition of fertilization capacity by sperm is regulated by intracellular pH (pH(i)), but the transport pathways that regulate pH(i) are not well understood. Lishko et al. (2010) now report that Hv1, the voltage-sensitive proton channel, is present in human sperm and is an important regulator of the functional maturation of sperm.
DOI of Published Version
Cell. 2010 Feb 5;140(3):310-2. Link to article on publisher's site
Florman HM, Jungnickel MK, Sutton KA. (2010). Shedding light on sperm pHertility. Florman Lab Publications. https://doi.org/10.1016/j.cell.2010.01.035. Retrieved from https://escholarship.umassmed.edu/florman/4