University of Massachusetts Medical School Faculty Publications
Title
Gaps in Knowledge and Research Priorities for Alcoholic Hepatitis
UMMS Affiliation
Department of Medicine, Division of Gastroenterology
Publication Date
2015-07-01
Document Type
Response or Comment
Subjects
*Hepatitis, Alcoholic; Humans; *Research
Disciplines
Digestive System Diseases | Gastroenterology | Hepatology
Abstract
Alcoholic hepatitis (AH) is a clinical syndrome that was classically characterized by increasing jaundice, hepatomegaly, fever, neutrophilia, and an aspartate aminotransferase (AST):alanine aminotransferase (ALT) ratio of >2. It is a major cause of liver-related hospitalizations in those with a history of heavy alcohol consumption and is also a leading etiology associated with recurrent hospitalizations. Unfortunately, despite its clinical relevance, there are many gaps in knowledge related to this syndrome that represent barriers to the development of effective preventive surveillance, early detection, and therapeutic strategies. This article summarizes the gaps in knowledge and identifies research priorities to fill these gaps.
DOI of Published Version
10.1053/j.gastro.2015.05.015
Source
Gastroenterology. 2015 Jul;149(1):4-9. doi: 10.1053/j.gastro.2015.05.015. Epub 2015 May 23. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Gastroenterology
PubMed ID
26008859
Repository Citation
Sanyal, Arun J.; Gao, Bin; and Szabo, Gyongyi, "Gaps in Knowledge and Research Priorities for Alcoholic Hepatitis" (2015). University of Massachusetts Medical School Faculty Publications. 965.
https://escholarship.umassmed.edu/faculty_pubs/965