University of Massachusetts Medical School Faculty Publications
Title
Mediators of inflammation and bone remodeling in rheumatic disease
UMMS Affiliation
Department of Medicine, Division of Rheumatology
Publication Date
2016-1
Document Type
Article
Disciplines
Cell Biology | Cellular and Molecular Physiology | Musculoskeletal Diseases | Rheumatology
Abstract
Remodeling of bone is a continuous process that occurs throughout life. Under normal physiologic conditions, bone-resorbing osteoclasts and bone-forming osteoblasts are tightly coupled and regulated to ensure proper balance, such that there is no net change in bone mass. However, inflammation perturbs normal bone homeostasis. The impact of inflammation on bone is dependent upon the anatomic site affected, cell types, factors and cytokines present in the local microenvironment, and local mechanical forces. Cytokines are central to the pathogenesis of inflammation-induced bone loss and contribute to the uncoupling of osteoclast-mediated bone resorption and osteoblast-mediated bone formation, thereby disrupting normal remodeling. In this review, we will discuss the effects of cytokines on bone in two settings, rheumatoid arthritis and spondyloarthritis, a disease category that includes ankylosing spondylitis, psoriatic arthritis, reactive arthritis, inflammatory bowel disease, and juvenile onset spondyloarthropathy. The outcome for bone in these disease settings is quite different, and an understanding of the pathogenic mechanisms leading to the net impact on bone has been essential in developing new therapeutic approaches to bone health in these diseases.
Keywords
Cytokines, Inflammation, Osteoblasts, Osteoclasts, Rheumatoid arthritis, Spondyloarthritis
DOI of Published Version
10.1016/j.semcdb.2015.10.013
Source
Semin Cell Dev Biol. 2016 Jan;49:2-10. doi: 10.1016/j.semcdb.2015.10.013. Epub 2015 Oct 19. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Seminars in cell and developmental biology
PubMed ID
26481971
Repository Citation
Shaw AT, Gravallese EM. (2016). Mediators of inflammation and bone remodeling in rheumatic disease. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1016/j.semcdb.2015.10.013. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/896