UMass Chan Medical School Faculty Publications


Nicotine and Resting-State Functional Connectivity: Effects of Intermittent Doses

UMMS Affiliation

Department of Psychiatry, Center for Comparative NeuroImaging; Department of Family Medicine and Community Health

Publication Date


Document Type



Neuroscience and Neurobiology | Psychiatry | Psychiatry and Psychology | Substance Abuse and Addiction


INTRODUCTION: It is unknown how the timing between doses might affect nicotine's impact on neural activity. Our objective was to examine how the interdose interval affects nicotine's impact on resting-state functional connectivity (rsFC).

MATERIALS AND METHODS: Adult male Sprague-Dawley rats were administered nicotine daily (0.4 mg/kg) over 6 days while control animals received saline vehicle. Functional magnetic resonance imaging was used to measure rsFC before and after a challenge dose of nicotine (0.4 mg/kg) delivered for the first time and 3, 6, 12, or 24hr after the previous dose.

RESULTS: As the interval between nicotine doses increased from 3 to 24hr, the strength of rsFC increased in some circuits, particularly the nucleus accumbens and prefrontal circuits, and decreased in others, namely the interpeduncular nucleus, hippocampus, caudoputamen, retrosplenial cortex, ventral tegmental, and the insular circuits.

CONCLUSIONS: These data indicate that the effect that nicotine has on the brain is affected by the amount of time that has passed since the previous dose. The effect on rsFC of cumulative doses is not additive. This may have important implications for the study of nicotine addiction as it implies that the same dose of nicotine might have a different impact on the brain depending on the time elapsed from the previous exposure.

DOI of Published Version



Nicotine Tob Res. 2015 Nov;17(11):1311-7. doi: 10.1093/ntr/ntv009. Epub 2015 Feb 2. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Nicotine and tobacco research : official journal of the Society for Research on Nicotine and Tobacco

PubMed ID