Impact of Plasmodium falciparum Coinfection on Longitudinal Epstein-Barr Virus Kinetics in Kenyan Children
Program in Molecular Medicine
Immunology of Infectious Disease | Infectious Disease | Parasitic Diseases | Parasitology | Virology | Virus Diseases
Endemic Burkitt lymphoma is associated with Epstein-Barr virus (EBV) and Plasmodium falciparum coinfection, although how P. falciparum exposure affects the dynamics of EBV infection is unclear. We have used a modeling approach to study EBV infection kinetics in a longitudinal cohort of children living in regions of high and low malaria transmission in Kenya. Residence in an area of high malaria transmission was associated with a higher rate of EBV expansion during primary EBV infection in infants and during subsequent episodes of EBV DNA detection, as well as with longer episodes of EBV DNA detection and shorter intervals between subsequent episodes of EBV DNA detection. In addition, we found that concurrent P. falciparum parasitemia also increases the likelihood of the first and subsequent peaks of EBV in peripheral blood. This suggests that P. falciparum infection is associated with increased EBV growth and contributes to endemic Burkitt lymphoma pathogenesis.
Burkitt lymphoma, Epstein-Barr virus, P. falciparum malaria, chronic infection, co-infection, infection dynamics
DOI of Published Version
J Infect Dis. 2016 Mar 15;213(6):985-91. doi: 10.1093/infdis/jiv525. Epub 2015 Nov 3. Link to article on publisher's site
The Journal of infectious diseases
Reynaldi, Arnold; Schlub, Timothy E.; Chelimo, Kiprotich; Sumba, Peter Odada; Piriou, Erwan; Ogolla, Sidney; Moormann, Ann M.; Rochford, Rosemary A.; and Davenport, Miles P., "Impact of Plasmodium falciparum Coinfection on Longitudinal Epstein-Barr Virus Kinetics in Kenyan Children" (2016). University of Massachusetts Medical School Faculty Publications. 869.