Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli
Department of Microbiology and Physiological Systems
*Bacterial Adhesion; Enterohemorrhagic Escherichia coli; Enteropathogenic Escherichia coli; Epithelial Cells; *Host-Pathogen Interactions
Bacteriology | Microbial Physiology | Pathogenic Microbiology
Enteropathogenic and enterohaemorrhagic Escherichia coli use a novel infection strategy to colonize the gut epithelium, involving translocation of their own receptor, Tir, via a type III secretion system and subsequent formation of attaching and effecting (A/E) lesions. Following integration into the host cell plasma membrane of cultured cells, and clustering by the outer membrane adhesin intimin, Tir triggers multiple actin polymerization pathways involving host and bacterial adaptor proteins that converge on the host Arp2/3 actin nucleator. Although initially thought to be involved in A/E lesion formation, recent data have shown that the known Tir-induced actin polymerization pathways are dispensable for this activity, but can play other major roles in colonization efficiency, in vivo fitness and systemic disease. In this review we summarize the roadmap leading from the discovery of Tir, through the different actin polymerization pathways it triggers, to our current understanding of their physiological functions.
DOI of Published Version
Cell Microbiol. 2013 Nov;15(11):1796-808. doi: 10.1111/cmi.12179. Epub 2013 Sep 3. Link to article on publisher's site
Lai, YuShuan (Cindy); Rosenshine, Ilan; Leong, John M.; and Frankel, Gad, "Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli" (2013). University of Massachusetts Medical School Faculty Publications. 816.