University of Massachusetts Medical School Faculty Publications

UMMS Affiliation

School of Medicine; Department of Urology

Publication Date


Document Type



Female Urogenital Diseases and Pregnancy Complications | Male Urogenital Diseases | Urology


Overactive bladder is a highly prevalent disorder with a significant impact on quality of life. Antimuscarinic agents are commonly used, but persistence is limited due to unsatisfactory efficacy and/or tolerability. Mirabegron is the first beta-3 adrenoceptor agonist approved for the treatment of overactive bladder syndrome. This paper reviews the pharmacology, mechanism of action, efficacy, and safety of mirabegron. A PubMed search of all English articles pertaining to mirabegron was performed. An alternative to antimuscarinics, mirabegron has a unique mechanism, improves overactive bladder symptoms and quality of life, and has limited adverse effects and few contraindications.


beta-3 agonist, incontinence, mirabegron, overactive bladder

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DOI of Published Version



Res Rep Urol. 2013 Oct 25;5:147-57. doi: 10.2147/RRU.S38792. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Research and reports in urology

PubMed ID


Creative Commons License

Creative Commons Attribution-Noncommercial 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License