Memory CD4 T cell-mediated immunity against influenza A virus: more than a little helpful
Department of Pathology
Animals; CD4-Positive T-Lymphocytes; Disease Models, Animal; Humans; Immunity, Cellular; *Immunologic Memory; Influenza A virus; Influenza, Human; Orthomyxoviridae Infections; T-Lymphocyte Subsets; T-Lymphocytes, Helper-Inducer
Immunity | Immunology of Infectious Disease | Immunopathology | Immunoprophylaxis and Therapy | Pathology
Recent observations have uncovered multiple pathways whereby CD4 T cells can contribute to protective immune responses against microbial threats. Incorporating the generation of memory CD4 T cells into vaccine strategies thus presents an attractive approach toward improving immunity against several important human pathogens, especially those against which antibody responses alone are inadequate to confer long-term immunity. Here, we review how memory CD4 T cells provide protection against influenza viruses. We discuss the complexities of protective memory CD4 T cell responses observed in animal models and the potential challenges of translating these observations into the clinic. Specifically, we concentrate on how better understanding of organ-specific heterogeneity of responding cells and defining multiple correlates of protection might improve vaccine-generated memory CD4 T cells to better protect against seasonal, and more importantly, pandemic influenza.
DOI of Published Version
Arch Immunol Ther Exp (Warsz). 2013 Oct;61(5):341-53. doi: 10.1007/s00005-013-0236-z. Epub 2013 May 25. Link to article on publisher's site
Archivum immunologiae et therapiae experimentalis
McKinstry, K. Kai; Dutton, Richard W.; Swain, Susan L.; and Strutt, Tara M., "Memory CD4 T cell-mediated immunity against influenza A virus: more than a little helpful" (2013). University of Massachusetts Medical School Faculty Publications. 766.